Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy

Gut

Volumn 56, Issue 12, 2007, Pages 1736-1742

  Weissenborn, Karin ^a   Ahl, Björn ^a   Fischer Wasels, Daniela ^a   Van Den Hoff, Joerg ^a   Hecker, Hartmut ^a   Burchert, Wolfgang ^a   Köstler, Herbert ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA N 13; FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; AMMONIA BLOOD LEVEL; ARTICLE; BRAIN METABOLISM; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GLUCOSE METABOLISM; HEPATIC ENCEPHALOPATHY; HUMAN; LIVER CIRRHOSIS; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ADULT; AGED; AMMONIA; BRAIN; BRAIN MAPPING; FEMALE; GLUCOSE; HEPATIC ENCEPHALOPATHY; HUMANS; LIVER CIRRHOSIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PSYCHOMETRICS; SEVERITY OF ILLNESS INDEX;

EID: 36749033636     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2006.110569     Document Type: Article

References (36)

1. Butterworth RF. Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies. J Hepatol 2003;39:278-85.
2. Shawcross J, Jalan R. The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation. Cell Mol Life Sci 2005;62:2295-304.
3. Rose C, Felipo V. Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Met Brain Dis 2005;20:275-83.
4. Häussinger D, Laubenberger J, vom Dahl S, et al. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology 1994;107:1475-80.
5. Zwingmann C, Butterworth R. An update on the role of brain glutamine synthesis and its relation to cell-specific energy metabolism in the hyperammonemic brain: further studies using NMR spectroscopy. Neurochem Int 2005;47:19-30.
6. Fischer-Wasels D, Burchert W, Köstler H, et al. Comparison between MRI, MRS, 18-FDG- and 13-NH3-PET data in cirrhotics with minimal hepatic encephalopathy (HE). J Hepatol 2000;32(Suppl.2): 64.
7. Pugh RNH, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-9.
8. Schomerus H, Weissenborn K, Hamster W, et al. PSE-Syndrom-Test. Psychodiagnostisches Verfahren zur quantitativen Erfassung der (minimalen) portosystemischen Enzephalopathie. Frankfurt: Swets Test Services, 1999.
9. Ferenci P, Lockwood AH, Mullen K, et al. Hepatic encephalopathy - definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congress of Gastroenterology, Vienna 1998. Hepatology 2002;35:716-21.
10. Brickenkamp R. Test d2. Aufmerksamkeits Belastungs Test. Göttingen, Toronto, Zürich: Verlag für Psychologie J. Hogrefe, 1981.
11. Keiding S, Sorensen M, Bender D, et al. Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by postron emission tomography. Hepatology 2006;43:42-50.
12. Ahl B, Weissenborn K, van den Hoff J, et al. Regional differences in cerebral blood flow and cerebral ammonia metabolism in cirrhotics. Hepatology 2004;40:73-9.
13. Hutchins GD, Schwaiger M, Rosenspire KC, et al. Noninvasive quantification of regional blood flow in the human heart using N-13-ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol 1990;15:1032-42.
14. Lockwood AH, Bolomey L, Napoleon F. Blood-brain barrier to ammonia in humans. J Cereb Blood Flow Metabol 1984;4:516-22.
15. Lockwood AH, Yap EWH, Wong W-H. Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy. J Cereb Blood Flow Metab 1991;11:337-41.
16. Blomqvist G. On the construction of functional maps in positron emission tomography. J Cereb Blood Flow Metab 1984;4:629-32.
17. van den Hoff J, Burchert W, Müller-Schauenburg W, et al. Accurate local blood flow measurements with dynamic PET: fast determination of input function delay and dispersion by multilinear minimization. J Nucl Med 1993;34:1770-2.
18. 13N] ammonia in human and canine blood. J Nucl Med 1990;31:163-7.
19. Patlak C, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metabol 1983;3:1-7.
20. Ong JP, Aggarwal A, Krieger D, et al. Correlation between ammonia levels and the severity of hepatic encephalopathy. Am J Med 2003,114:188-93.
21. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain, 2nd ed. Stuttgart: Thieme Verlag, 1988.
22. Chamuleau R, Bosman DK, Bovee W, et al. What the clinician can learn from MR glutamine/glutamate assays. NMR Biomed 1991;4:103-8.
23. 1H NMR spectroscopy in patients with chronic hepatic encephalopathy: analysis of changes in cerebral glutamine, choline and inositols. NMR Biomed 1991;4:109-16.
24. Geissler A, Lock G, Fründ R, et al. Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging. Hepatology 1997;25:48-54.
25. Köstler H. Proton magnetic resonance spectroscopy in portal-systemic encephalopathy. Metab Brain Dis 1998;13:291-301.
26. Lee JH, Seo DW, Lee YS, et al. Proton magnetic resonance spectroscopy (1H-MRS) findings in the brain in patients with liver cirrhosis reflect the hepatic functional reserve. Am J Gastroenterol 1999;94:2206-13.
27. Cordoba J, Sanpedro F, Alonso J, et al. 1H magnetic resonance in the study of hepatic encephalopathy in humans. Metabol Brain Dis 2002;17:415-29.
28. Taylor-Robinson SD, Sargentoni J, Marcus CD, et al. Regional variations in cerebral proton spectroscopy in patients with chronic hepatic encephalopathy. Metab Brain Dis 1994;9:347-59.
29. Pujol J, Kulisevsky J, Moreno A, et al. Neurospectroscopic alterations and globus pallidus hyperintensity as related magnetic resonance markers of reversible hepatic encephalopathy. Neurology 1996;47:1526-30.
30. Spahr L, Vingerhoets F, Lazeyras F, et al. Magnetic resonance imaging and proton spectroscopic alterations correlate with parkinsonian signs in patients with cirrhosis. Gastroenterology 2000;119:774-81.
31. Morgan MY. Cerebral magnetic resonance imaging in patients with chronic liver disease. Metab Brain Dis 1998;13:273-90.
32. Balata S, Olde Damink SWM, Ferguson, Marshall I, et al. Induced hyperammmonemia alters neuropsychology, brain mr spectroscopy and magnetization transfer in cirrhosis. Hepatology 2003;37:931-9.
33. Lockwood AH, Yap EWH, Rhoades HM, et al. Altered cerebral blood flow and glucose metabolism in patients with liver disease and minimal encephalopathy. J Cereb Blood Flow Metab 1991;11:331-6.
34. Lockwood AH, Murphy BW, Donnelly KZ, et al. Positron-emission tomographic localization of abnormalities of brain metabolism in patients with minimal hepatic encephalopathy. Hepatology 1993;18:1061-8.
35. Lockwood AH, Weissenborn K, Bokemeyer M, et al. Correlations between cerebral glucose metabolism and neuropsychological test performance in non-alcoholic cirrhotics. Metab Brain Dis 2002;17:29-40.
36. Häussinger D. Low grade cerebral edema in the pathogenesis of hepatic encephalopathy in cirrhosis. Hepatology 2006;43:1187-90.