Promoter hypermethylation using 24-gene array in early head and neck cancer: Better outcome in oral than in oropharyngeal cancer

Epigenetics

Volumn 9, Issue 9, 2014, Pages 1220-1227

  Noorlag, Rob ^a   van Kempen, Pauline M W ^a   Moelans, Cathy B ^a   de Jong, Rick ^a   Blok, Laura E R ^a   Koole, Ronald ^a   Grolman, Wilko ^a   van Diest, Paul J ^a   van Es, Robert J J ^a   Willems, Stefan M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

DNA methylation; Head neck cancer; Hypermethylation; Oral cancer; Oropharyngeal cancer; Prognosis; Squamous cell carcinoma; Tumor suppressor gene

Indexed keywords

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SPECIFIC SURVIVAL; CANCER STAGING; CARCINOGENESIS; CLINICAL FEATURE; CONTROLLED STUDY; DNA EXTRACTION; DNA ISOLATION; DNA METHYLATION; DNA MICROARRAY; FEMALE; GENE AMPLIFICATION; GENE SILENCING; GENETIC ANALYSIS; HEAD AND NECK CANCER; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; OROPHARYNX CANCER; PATHOLOGY; PROMOTER REGION; QUANTITATIVE ASSAY; TUMOR SUPPRESSOR GENE; VERY ELDERLY; DISEASE FREE SURVIVAL; GENETICS; HEAD AND NECK TUMOR; METABOLISM; MIDDLE AGED; MOUTH TUMOR; OROPHARYNX TUMOR; PROCEDURES; SQUAMOUS CELL CARCINOMA; YOUNG ADULT;

TUMOR MARKER;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; DNA METHYLATION; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OROPHARYNGEAL NEOPLASMS; PROMOTER REGIONS, GENETIC; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84908221466     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.29785     Document Type: Article

References (46)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61:69-90; PMID:21296855; http://dx.doi. org/10.3322/caac.20107
2. Crowe DL, Hacia JG, Hsieh CL, Sinha UK, Rice H. Molecular pathology of head and neck cancer. Histol Histopathol 2002; 17:909-14; PMID:12168802
3. Leemans CR, Braakhuis BJ, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer 2011; 11:9-22; PMID:21160525; http:// dx.doi.org/10.1038/nrc2982
4. Tsai HC, Baylin SB. Cancer epigenetics: linking basic biology to clinical medicine. Cell Res 2011; 21:502- 17; PMID:21321605; http://dx.doi.org/10.1038/ cr.2011.24
5. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3:415-28; PMID:12042769
6. Robertson KD. DNA methylation and human disease. Nat Rev Genet 2005; 6:597-610; PMID:16136652; http://dx.doi.org/10.1038/nrg1655
7. Gasche JA, Goel A. Epigenetic mechanisms in oral carcinogenesis. Future Oncol 2012; 8:1407- 25; PMID:23148615; http://dx.doi.org/10.2217/ fon.12.138
8. Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000; 16:168-74; PMID:10729832; http:// dx.doi.org/10.1016/S0168-9525(99)01971-X
9. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003; 349:2042-54; PMID:14627790; http:// dx.doi.org/10.1056/NEJMra023075
10. van Kempen PM, Noorlag R, Braunius WW, Stegeman I, Willems SM, Grolman W. Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma: a systematic review. Epigenetics 2014; 9:194-203; PMID:24169583; http://dx.doi.org/10.4161/ epi.26881
11. Demokan S, Dalay N. Role of DNA methylation in head and neck cancer. Clin Epigenetics 2011; 2:123- 50; PMID:22704334; http://dx.doi.org/10.1007/ s13148-011-0045-3
12. Verschuur-Maes AH, de Bruin PC, van Diest PJ. Epigenetic progression of columnar cell lesions of the breast to invasive breast cancer. Breast Cancer Res Treat 2012; 136:705-15; PMID:23104224; http:// dx.doi.org/10.1007/s10549-012-2301-4
13. Chen K, Sawhney R, Khan M, Benninger MS, Hou Z, Sethi S, Stephen JK, Worsham MJ. Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2007; 133:1131- 8; PMID:18025318; http://dx.doi.org/10.1001/ archotol.133.11.1131
14. Yalniz Z, Demokan S, Suoglu Y, Ulusan M, Dalay N. Simultaneous methylation profiling of tumor suppressor genes in head and neck cancer. DNA Cell Biol 2011; 30:17-24; PMID:20860434; http:// dx.doi.org/10.1089/dna.2010.1090
15. Sun D, Zhang Z, Van N, Huang G, Ernberg I, Hu L. Aberrant methylation of CDH13 gene in nasopharyngeal carcinoma could serve as a potential diagnostic biomarker. Oral Oncol 2007; 43:82- 7; PMID:16807071; http://dx.doi.org/10.1016/j. oraloncology.2006.01.007
16. Shaw RJ, Hall GL, Lowe D, Liloglou T, Field JK, Sloan P, Risk JM. The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression. Arch Otolaryngol Head Neck Surg 2008; 134:251- 6; PMID:18347248; http://dx.doi.org/10.1001/ archoto.2007.50
17. Claus R, Wilop S, Hielscher T, Sonnet M, Dahl E, Galm O, Jost E, Plass C. A systematic comparison of quantitative high-resolution DNA methylation analysis and methylation-specific PCR. Epigenetics 2012; 7:772-80; PMID:22647397; http://dx.doi. org/10.4161/epi.20299
18. Hömig-Hölzel C, Savola S. Multiplex ligationdependent probe amplification (MLPA) in tumor diagnostics and prognostics. Diagn Mol Pathol 2012; 21:189-206; PMID:23111197; http://dx.doi. org/10.1097/PDM.0b013e3182595516
19. Stuppia L, Antonucci I, Palka G, Gatta V. Use of the MLPA Assay in the Molecular Diagnosis of Gene Copy Number Alterations in Human Genetic Diseases. Int J Mol Sci 2012; 13:3245-76; PMID:22489151; http://dx.doi.org/10.3390/ijms13033245
20. Suijkerbuijk KP, Pan X, van der Wall E, van Diest PJ, Vooijs M. Comparison of different promoter methylation assays in breast cancer. Anal Cell Pathol (Amst) 2010; 33:133-41; PMID:20978321
21. Leong KJ, Wei W, Tannahill LA, Caldwell GM, Jones CE, Morton DG, Matthews GM, Bach SP. Methylation profiling of rectal cancer identifies novel markers of early-stage disease. Br J Surg 2011; 98:724- 34; PMID:21360524; http://dx.doi.org/10.1002/ bjs.7422
22. Cardoso LC, Tenorio Castaño JA, Pereira HS, Lima MA, Dos Santos AC, de Faria PS, Ferman S, Seuánez HN, Nevado JB, de Almeida JC, et al. Constitutional and somatic methylation status of DMRH19 and KvDMR in Wilms tumor patients. Genet Mol Biol 2012; 35:714-24; PMID:23271929; http://dx.doi. org/10.1590/S1415-47572012005000073
23. López F, Sampedro T, Llorente JL, Domínguez F, Hermsen M, Suárez C, Alvarez-Marcos C. Utility of MS-MLPA in DNA methylation profiling in primary laryngeal squamous cell carcinoma. Oral Oncol 2014; 50:291-7; PMID:24444674; http://dx.doi. org/10.1016/j.oraloncology.2014.01.003
24. Furlan D, Sahnane N, Mazzoni M, Pastorino R, Carnevali I, Stefanoli M, Ferretti A, Chiaravalli AM, La Rosa S, Capella C. Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum. Virchows Arch 2013; 462:47-56; PMID:23224118; http://dx.doi.org/10.1007/s00428-012-1348-2
25. Pineda M, Mur P, Iniesta MD, Borràs E, Campos O, Vargas G, Iglesias S, Fernández A, Gruber SB, Lázaro C, et al. MLH1 methylation screening is effective in identifying epimutation carriers. Eur J Hum Genet 2012; 20:1256-64; PMID:22763379; http://dx.doi. org/10.1038/ejhg.2012.136
26. Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R, Roviello F, Oliveira C. Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer. J Clin Oncol 2013; 31:868-75; PMID:23341533; http://dx.doi.org/10.1200/JCO.2012.44.4612
27. Marsit CJ, Posner MR, McClean MD, Kelsey KT. Hypermethylation of E-cadherin is an independent predictor of improved survival in head and neck squamous cell carcinoma. Cancer 2008; 113:1566- 71; PMID:18711702; http://dx.doi.org/10.1002/ cncr.23770
28. Castro M, Grau L, Puerta P, Gimenez L, Venditti J, Quadrelli S, Sánchez-Carbayo M. Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer. J Transl Med 2010; 8:86; PMID:20849603; http://dx.doi. org/10.1186/1479-5876-8-86
29. Kim DH, Nelson HH, Wiencke JK, Zheng S, Christiani DC, Wain JC, Mark EJ, Kelsey KT. p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in nonsmall cell lung cancer. Cancer Res 2001; 61:3419-24; PMID:11309302
30. Toyooka S, Maruyama R, Toyooka KO, McLerran D, Feng Z, Fukuyama Y, Virmani AK, Zochbauer- Muller S, Tsukuda K, Sugio K, et al. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer 2003; 103:153-60; PMID:12455028; http://dx.doi.org/10.1002/ijc.10787
31. Lleras RA, Smith RV, Adrien LR, Schlecht NF, Burk RD, Harris TM, Childs G, Prystowsky MB, Belbin TJ. Unique DNA methylation loci distinguish anatomic site and HPV status in head and neck squamous cell carcinoma. Clin Cancer Res 2013; 19:5444-55; PMID:23894057; http://dx.doi. org/10.1158/1078-0432.CCR-12-3280
32. Colacino JA, Dolinoy DC, Duffy SA, Sartor MA, Chepeha DB, Bradford CR, McHugh JB, Patel DA, Virani S, Walline HM, et al. Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics. PLoS One 2013; 8:e54742; PMID:23358896; http://dx.doi. org/10.1371/journal.pone.0054742
33. Huang KH, Huang SF, Chen IH, Liao CT, Wang HM, Hsieh LL. Methylation of RASSF1A, RASSF2A, and HIN-1 is associated with poor outcome after radiotherapy, but not surgery, in oral squamous cell carcinoma. Clin Cancer Res 2009; 15:4174-80; PMID:19509163; http://dx.doi.org/10.1158/1078- 0432.CCR-08-2929
34. Conacci-Sorrell M, Zhurinsky J, Ben-Ze'ev A. The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest 2002; 109:987-91; PMID:11956233; http://dx.doi.org/10.1172/ JCI0215429
35. Adachi Y, Takeuchi T, Nagayama T, Furihata M. T-cadherin modulates tumor-associated molecules in gallbladder cancer cells. Cancer Invest 2010; 28:120-6; PMID:20121546; http://dx.doi. org/10.3109/07357900903124472
36. Kim WY, Lee JW, Park YA, Choi JJ, Sung CO, Song SY, Choi CH, Kim TJ, Huh SJ, Kim BG, et al. RAR-beta expression is associated with early volumetric changes to radiation therapy in cervical cancer. Gynecol Obstet Invest 2011; 71:11-8; PMID:21160189; http://dx.doi.org/10.1159/000320719
37. Sanbhnani S, Yeong FM. CHFR: a key checkpoint component implicated in a wide range of cancers. Cell Mol Life Sci 2012; 69:1669-87; PMID:22159584; http://dx.doi.org/10.1007/s00018-011-0892-2
38. Chow JP, Man WY, Mao M, Chen H, Cheung F, Nicholls J, Tsao SW, Li Lung M, Poon RY. PARP1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy. Mol Cancer Ther 2013; 12:2517-28; PMID:23979918; http://dx.doi. org/10.1158/1535-7163.MCT-13-0010
39. Khan K, Araki K, Wang D, Li G, Li X, Zhang J, Xu W, Hoover RK, Lauter S, O'Malley B Jr., et al. Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427. Head Neck 2010; 32:381-91; PMID:19672867
40. Liu SS, Leung RC, Chan KY, Chiu PM, Cheung AN, Tam KF, Ng TY, Wong LC, Ngan HY. p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy. Clin Cancer Res 2004; 10:3309-16; PMID:15161684; http://dx.doi. org/10.1158/1078-0432.CCR-03-0119
41. van Diest PJ. No consent should be needed for using leftover body material for scientific purposes. For. BMJ 2002; 325:648-51; PMID:12242180; http:// dx.doi.org/10.1136/bmj.325.7365.648
42. Smeets SJ, Hesselink AT, Speel EJ, Haesevoets A, Snijders PJ, Pawlita M, Meijer CJ, Braakhuis BJ, Leemans CR, Brakenhoff RH. A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer 2007; 121:2465-72; PMID:17680565; http://dx.doi.org/10.1002/ijc.22980
43. Farshadpour F, Konings S, Speel EJ, Hordijk GJ, Koole R, van Blokland M, Slootweg PJ, Kummer JA. Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study regarding Tobacco and Alcohol Consumption. Patholog Res Int. 2011;2011:806345
44. Shaw R. The epigenetics of oral cancer. Int J Oral Maxillofac Surg 2006; 35:101-8; PMID:16154320; http://dx.doi.org/10.1016/j.ijom.2005.06.014
45. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j. cell.2011.02.013
46. Nygren AO, Ameziane N, Duarte HM, Vijzelaar RN, Waisfisz Q, Hess CJ, Schouten JP, Errami A. Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res 2005; 33:e128; PMID:16106041; http://dx.doi. org/10.1093/nar/gni127