Lgl regulates notch signaling via endocytosis, independently of the apical aPKC-Par6-Baz polarity complex

Current Biology

Volumn 24, Issue 18, 2014, Pages 2073-2084

  Parsons, Linda M ^a,b   Portela, Marta ^a   Grzeschik, Nicola A ^a   Richardson, Helena E ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; LETHAL (2) GIANT LARVAE PROTEIN, DROSOPHILA; NOTCH PROTEIN, DROSOPHILA; NOTCH RECEPTOR; TUMOR SUPPRESSOR PROTEIN;

ANIMAL; COMPOUND EYE; DROSOPHILA MELANOGASTER; ENDOCYTOSIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; LARVA; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; COMPOUND EYE, ARTHROPOD; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOCYTOSIS; LARVA; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84908221099     PISSN: 09609822     EISSN: 18790445     Source Type: Journal    
DOI: 10.1016/j.cub.2014.07.075     Document Type: Article

References (52)

1. J. Roignot, X. Peng, and K. Mostov Polarity in mammalian epithelial morphogenesis Cold Spring Harb. Perspect. Biol. 5 2013 a013789
2. U. Tepass The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival Annu. Rev. Cell Dev. Biol. 28 2012 655 685
3. J.M. Shivas, H.A. Morrison, D. Bilder, and A.R. Skop Polarity and endocytosis: reciprocal regulation Trends Cell Biol. 20 2010 445 452
4. H.W. Platta, and H. Stenmark Endocytosis and signaling Curr. Opin. Cell Biol. 23 2011 393 403
5. J. Chen, and M. Zhang The Par3/Par6/aPKC complex and epithelial cell polarity Exp. Cell Res. 319 2013 1357 1364
6. B.J. Thompson Cell polarity: models and mechanisms from yeast, worms and flies Development 140 2013 13 21
7. I. Elsum, L. Yates, P.O. Humbert, and H.E. Richardson The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man Essays Biochem. 53 2012 141 168
8. F. Martin-Belmonte, and M. Perez-Moreno Epithelial cell polarity, stem cells and cancer Nat. Rev. Cancer 12 2012 23 38
9. S.F. Ang, and H. Fölsch The role of secretory and endocytic pathways in the maintenance of cell polarity Essays Biochem. 53 2012 29 39
10. M. Georgiou, E. Marinari, J. Burden, and B. Baum Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability Curr. Biol. 18 2008 1631 1638
11. A. Leibfried, R. Fricke, M.J. Morgan, S. Bogdan, and Y. Bellaiche Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis Curr. Biol. 18 2008 1639 1648
12. K.P. Harris, and U. Tepass Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis J. Cell Biol. 183 2008 1129 1143
13. H.M. Herz, Z. Chen, H. Scherr, M. Lackey, C. Bolduc, and A. Bergmann vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis Development 133 2006 1871 1880
14. B.J. Thompson, J. Mathieu, H.H. Sung, E. Loeser, P. Rørth, and S.M. Cohen Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila Dev. Cell 9 2005 711 720
15. T. Vaccari, and D. Bilder The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking Dev. Cell 9 2005 687 698
16. K.H. Moberg, S. Schelble, S.K. Burdick, and I.K. Hariharan Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth Dev. Cell 9 2005 699 710
17. B. Ma, Y. Xiang, and L. An Structural bases of physiological functions and roles of the vacuolar H(+)-ATPase Cell. Signal. 23 2011 1244 1256
18. Y. Yan, N. Denef, and T. Schüpbach The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila Dev. Cell 17 2009 387 402
19. T. Vaccari, H. Lu, R. Kanwar, M.E. Fortini, and D. Bilder Endosomal entry regulates Notch receptor activation in Drosophila melanogaster J. Cell Biol. 180 2008 755 762
20. A.G. Petzoldt, E.M. Gleixner, A. Fumagalli, T. Vaccari, and M. Simons Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium Dis. Model. Mech. 6 2013 689 700
21. V. Kandachar, and F. Roegiers Endocytosis and control of Notch signaling Curr. Opin. Cell Biol. 24 2012 534 540
22. M.E. Fortini, and D. Bilder Endocytic regulation of Notch signaling Curr. Opin. Genet. Dev. 19 2009 323 328
23. S. Artavanis-Tsakonas, and M.A. Muskavitch Notch: the past, the present, and the future Curr. Top. Dev. Biol. 92 2010 1 29
24. W. Helms, H. Lee, M. Ammerman, A.L. Parks, M.A.T. Muskavitch, and B. Yedvobnick Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function Dev. Biol. 215 1999 358 374
25. A. Baonza, and M. Freeman Control of cell proliferation in the Drosophila eye by Notch signaling Dev. Cell 8 2005 529 539
26. L.C. Firth, and N.E. Baker Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye Dev. Cell 8 2005 541 551
27. C. Reiter, T. Schimansky, Z. Nie, and K.F. Fischbach Reorganization of membrane contacts prior to apoptosis in the Drosophila retina: the role of the IrreC-rst protein Development 122 1996 1931 1940
28. H. Apitz, M. Strünkelnberg, H.G. de Couet, and K.F. Fischbach Single-minded, Dmef2, Pointed, and Su(H) act on identified regulatory sequences of the roughest gene in Drosophila melanogaster Dev. Genes Evol. 215 2005 460 469
29. N.A. Grzeschik, N. Amin, J. Secombe, A.M. Brumby, and H.E. Richardson Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye Dev. Biol. 311 2007 106 123
30. N.A. Grzeschik, L.M. Parsons, M.L. Allott, K.F. Harvey, and H.E. Richardson Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms Curr. Biol. 20 2010 573 581
31. J.E. Hinshaw, and S.L. Schmid Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding Nature 374 1995 190 192
32. V. Sriram, K.S. Krishnan, and S. Mayor deep-orange and carnation define distinct stages in late endosomal biogenesis in Drosophila melanogaster J. Cell Biol. 161 2003 593 607
33. J. Rohrer, A. Schweizer, D. Russell, and S. Kornfeld The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane J. Cell Biol. 132 1996 565 576
34. H. Lu, and D. Bilder Endocytic control of epithelial polarity and proliferation in Drosophila Nat. Cell Biol. 7 2005 1232 1239
35. R.L. Williams, and S. Urbé The emerging shape of the ESCRT machinery Nat. Rev. Mol. Cell Biol. 8 2007 355 368
36. J. Yousefian, T. Troost, F. Grawe, T. Sasamura, M. Fortini, and T. Klein Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila J. Cell Sci. 126 2013 1583 1594
37. M.A. Akbar, S. Ray, and H. Krämer The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles Mol. Biol. Cell 20 2009 1705 1714
38. M. Komada, and N. Kitamura The Hrs/STAM complex in the downregulation of receptor tyrosine kinases J. Biochem. 137 2005 1 8
39. E. Mizuno, K. Kawahata, A. Okamoto, N. Kitamura, and M. Komada Association with Hrs is required for the early endosomal localization, stability, and function of STAM J. Biochem. 135 2004 385 396
40. T. Vaccari, S. Duchi, K. Cortese, C. Tacchetti, and D. Bilder The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor Development 137 2010 1825 1832
41. S. Sotillos, M.T. Díaz-Meco, E. Caminero, J. Moscat, and S. Campuzano DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila J. Cell Biol. 166 2004 549 557
42. N.A. Grzeschik, L.M. Parsons, and H.E. Richardson Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition! Cell Cycle 9 2010 3202 3212
43. M. Schneider, T. Troost, F. Grawe, A. Martinez-Arias, and T. Klein Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome J. Cell Sci. 126 2013 645 656
44. E.C. Richardson, and F. Pichaud Crumbs is required to achieve proper organ size control during Drosophila head development Development 137 2010 641 650
45. M. Roy, W.S. Pear, and J.C. Aster The multifaceted role of Notch in cancer Curr. Opin. Genet. Dev. 17 2007 52 59
46. G. Farnie, and R.B. Clarke Mammary stem cells and breast cancer - role of Notch signalling Stem Cell Rev. 3 2007 169 175
47. O. Klezovitch, T.E. Fernandez, S.J. Tapscott, and V. Vasioukhin Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice Genes Dev. 18 2004 559 571
48. B.S. Clark, S. Cui, J.B. Miesfeld, O. Klezovitch, V. Vasioukhin, and B.A. Link Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis Development 139 2012 1599 1610
49. A. Hernandez, G. Serrano-Bueno, J.R. Perez-Castineira, and A. Serrano Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer Curr. Pharm. Des. 18 2012 1383 1394
50. A.E. Christiansen, T. Ding, Y. Fan, H.K. Graves, H.M. Herz, J.L. Lindblad, and A. Bergmann Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila Cell Death Differ. 20 2013 302 311
51. T. Lee, and L. Luo Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development Trends Neurosci. 24 2001 251 254
52. L.M. Parsons, N.A. Grzeschik, and H.E. Richardson lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK Cancers 6 2014 879 896