Preparation of Mevinolinic Acid from Monascus purpureus Using High-Speed Countercurrent Chromatography (HSCCC)

Journal of Liquid Chromatography and Related Technologies

Volumn 26, Issue 18, 2003, Pages 3085-3092

  Du, Qizhen ^a   Xia, Ming ^a   Ito, Yoichiro ^b  

^a ZHEJIANG GONGSHANG UNIVERSITY   (China)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

High speed countercurrent chromatography; Mevinolinic acid; Monascus purpureus; Preparation

Indexed keywords

IONIZATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; ORGANIC ACIDS; ORGANIC SOLVENTS;

ELECTROSPRAY IONIZATION;

LIQUID CHROMATOGRAPHY;

ACETIC ACID ETHYL ESTER; HERBACEOUS AGENT; HEXANE; METHANOL; MEVINOLIN; MEVINOLINIC ACID; MONASCUS PURPUREUS EXTRACT; PLANT EXTRACT; SOLVENT; UNCLASSIFIED DRUG; WATER;

ALKALINITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL COMPOSITION; COUNTER CURRENT CHROMATOGRAPHY; DRUG DEGRADATION; DRUG PURITY; DRUG SYNTHESIS; DRUG TRANSFORMATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH SPEED COUNTER CURRENT CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINAL PLANT; MONASCUS PURPUREUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; SEPARATION TECHNIQUE;

MONASCUS; MONASCUS PURPUREUS;

EID: 0242609347     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120025425     Document Type: Article

References (11)

1. Alberts, A.W.; Chen, J.; Kuron, G.; Hunt, V.; Huff, J.; Hoffman, C.; Rothrock, J.; Lopez, M.; Joshua, H.; Harris, E.; Patchett, A.; Monaghan, R.; Currie, S.; Stapley, E.; Albers-Schonberg, G.; Hensens, O.; Hirshfield, J.; Hoogsteen, K.; Liesch, J.; Springer, J. A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme. A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. 1980, 77, 3957-3961.
2. Wang, J.; Lu, Z.; Chi, J.; Wang, W.; Su, M.; Kou, W.; Yu, P.; Yu, L.; Chen, L.; Zhu, J.-S.; Chang, J. Multicenter clinical trial of serum lipid-lowering effects of a Monascus purpureus (red yeast) rice preparation from traditional Chinese medicine. J. Curr. Ther. Res. 1997, 58, 964-978.
3. Shen, Z.; Yu, P.; Sun, M.; Chi, J.; Zhou, Y.; Zhu, X.; Yang, C.; He, C. A prospective study on Zhitai capsule in the treatment of primary hyper-lipidemia. Natl. Med. J. China 1996, 76, 156-157.
4. Heber, D.; Yip, I.; Ashley, J.M.; Elashoff, D.A.; Elashoff, R.M.; Go, V.L.W. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am. J. Clin. Nutr. 1999, 69, 231-236.
5. Li, C.; Zhu, Y.; Wang, Y.; Zhu, J.-S.; Chang, J.; Kritchevsky, D. Monascus purpureus-fermented rice (red yeast rice): a natural food product that lowers blood cholesterol in animal models of hypercholesterolemia. Nutr. Res. 1998, 18, 71-78.
6. Baranova, N.A.; Kreier, V.G.; Egorov, N.S. Action of lovastatin - an inhibitor of cholesterol biosynthesis on bacterial bioluminescence. Antibiot. Khimioter. 1995, 40, 12-16.
7. Ma, J.; Li, Y.; Ye, Q.; Li, J.; Hua, Y.; Ju, D.; Zhang, D.; Coop, R.; Chang, M.M. Constituent of red yeast rice, a traditional Chinese food and medicine. J. Agri. Food Chem. 2000, 48, 5220-5226.
8. Ito, Y. High speed countercurrent chromatography. CRC Crit. Rev. Anal. Chem. 1986, 17, 65.
9. Du, Q.; Li, Z.; Ito, Y. Preparative separation of isoflavone components in soybeans using high-speed countercurrent chromatography. J. Chromatogr. A 2001, 923, 271-274.
10. Stubbs, R.; Schwartz, M.; Bayne, W.F. Determination of mevinolin and mevinolinic acid in plasma and bile by reversed high-performance liquid chromatography. J. Chromatogr. 1986, 383, 438-443.
11. Endo, A.; Hasumi, K.; Nakamura, T.; Kunishima, M.; Masuda, M. Dihydromonacolin L and monacolin X, new metabolites that inhibit cholesterol biosynthesis. J. Antibiot. 1984, 38, 321-327.