Positive selection during the evolution of the blood coagulation factors in the context of their disease-causing mutations

Molecular Biology and Evolution

Volumn 31, Issue 11, 2014, Pages 3040-3056

  Rallapalli, Pavithra M ^a   Orengo, Christine A ^a   Studer, Romain A ^a   Perkins, Stephen J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

coagulation; evolution; hemostasis; positive selection

Indexed keywords

AMINO ACID; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; FIBRINOGEN; PROTHROMBIN; THROMBOPLASTIN;

AMINO ACID SUBSTITUTION; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING FACTOR 11 DEFICIENCY; CLADISTICS; CODON; CONTROLLED STUDY; DNA SEQUENCE; EVOLUTIONARY ADAPTATION; FIBRIN CLOT; FISH; GENETIC CODE; GENETIC DRIFT; GENOME; GLIRES; HEMOPHILIA A; HEMOPHILIA B; HUMAN; LAURASIATHERIA; MAMMAL; MISSENSE MUTATION; MULTIGENE FAMILY; MUTATIONAL ANALYSIS; NATURAL SELECTION; NONHUMAN; PHENOTYPE; PHYLOGENY; PRIMATE; PROTEIN STABILITY; PROTEIN STRUCTURE; SAUROPSID; SEQUENCE ALIGNMENT; VERTEBRATE; ANIMAL; BLOOD CLOTTING DISORDER; GENETIC SELECTION; GENETICS; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE;

ANIMALS; BASE SEQUENCE; BLOOD COAGULATION DISORDERS; EVOLUTION, MOLECULAR; FACTOR IX; FACTOR VIII; FACTOR XI; FIBRINOGEN; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; SELECTION, GENETIC; SEQUENCE ALIGNMENT; VERTEBRATES;

EID: 84908203373     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu248     Document Type: Article

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