Nephrotoxicity and hepatotoxicity evaluation of Crocus sativus stigmas in neonates of nursing mice

Journal of Nephropathology

Volumn 3, Issue 2, 2014, Pages 81-85

  Bahmani, Mahmoud ^a,b   Rafieian, Mortaza ^c   Baradaran, Azar ^d   Rafieian, Samira ^d   Rafieian Kopaei, Mahmoud ^e  

^a URMIA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c Isfahan Governor Office   (Iran)

^d ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute toxicity; Crocus sativus; Saffron; Subacute toxicity

Indexed keywords

EID: 84908201135     PISSN: 22518363     EISSN: 22518819     Source Type: Journal    
DOI: 10.12860/jnp.2014.16     Document Type: Article

References (22)

1. Rabiei Z, Rafieian-kopaei M, Heidarian E, Saghaei E, Mokhtari S. Effects of zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus basalis of meynert in rat. Neurochem Res 2014;39(2):353-60.
2. Rabiei Z, Rafieian-Kopaei M, Mokhtari S, Alibabaei Z, Shahrani M. The effect of pretreatment with different doses of Lavandula officinalis ethanolic extract on memory, learning and nociception. Biomed Aging Pathol 2014; 4:71-76.
3. Mohammadifard N, Sarrafzadegan N, Sajjadi F, Maghroun M, Khosravi A, Alikhasi H, et al. Potato consumption and cardiovascular disease risk factors among Iranian population. Int J Food Sci Nutr 2012; 63(8):913-20.
4. Nasri H, Sahinfard N, Rafieian M, Rafieian S, Shirzad M, Rafieian-kopaei M. Effects of Allium sativum on liver enzymes and atherosclerotic risk factors. J HerbMed Pharmacol 2013; 2(2):23-28.
5. Kafash-Farkhad N, Asadi-Samani M, Rafieian-Kopaei M. A review on phytochemistry and pharmacological effects of Prangos ferulacea (L.) Lindl. Life Sci J 2013; 10(8s):360-367.
6. Mirhoseini M, Baradaran A, Rafieian-Kopaei M. Medicinal plants, diabetes mellitus and urgent needs. J HerbMed Pharmacol 2013; 2(2):53-54.
7. Shirzad H, Shahrani M, Rafieian-Kopaei M. Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo. Int Immunopharmacol 2009; 9(7-8):968-70.
8. Shirzad H, Taji F, Rafieian-Kopaei M. Correlation between antioxidant activity of garlic extracts and WEHI-164 fibrosarcoma tumor growth in BALB/c mice. J Med Food 2011; 14(9):969-74.
9. Sedighi M, Rafieian-kopaei M, Noori-Ahmadabadi M. Kelussia odoratissima Mozaffarian inhibits ileum contractions through voltage dependent and beta adrenergic Receptors. Life Sci 2012; 9(4):1033-8.
10. Kiani MA, Khodadad A, Mohammadi S, Ghayour Mobarhan M, Saeidi M, Jafari SA, et al. Effect of peppermint on pediatrics’ pain under endoscopic examination of the large bowel. J HerbMed Pharmacol 2013; 2(2):41-44.
11. Rafieian-Kopaei M. Medicinal plants and the human needs. J HerbMed Plarmacol 2012; 1(1):1-2.
12. Nasri H, Shirzad H. Toxicity and safety of medicinal plants. J HerbMed Plarmacol 2013; 2(2): 21-22.
13. Mazhari N. Iridaceae. In: Asadi M, editor. Flora of Iran. Vol. 31. Tehran: Research Institute of Forests and Rangelands; 2000. pp. 4–6.
14. Daniel M. Medicinal Plants: Chemistry and Properties. Enfield: Science Publishers; 2006. pp. 138.
15. Javadi B, Sahebkar A, Emami SA. A survey on saffron in major Islamic traditional medicine books. Iran J Basic Med Sci 2013; 16(1):1–11.
16. Schmidt M, Betti G, Hensel A. Saffron in phytotherapy: Pharmacology and clinical uses. Wien Med Wochenschr 2007; 157(33):315-9
17. Hosseinzadeh H, Shariaty MV, Khadem-Sameni A, Vahabzadeh M. Acute and sub-acute toxicity of crocin, a constituent of Crocus sativus L. (saffron), in mice and rats. Pharmacologyonline 2010; 2:943-51.
18. Piyachaturawat P, Tubtim C, Chuncharunee A, Komaratat P, Suksamrarn A. Evaluation of the acute and subacute toxicity of a choleretic phloracetophenone in experimental animals. Toxicol Let 2002; 129:123-32.
19. Loomis T. Essential of Toxicology. Philladelphia:Lea and Febiger;1968. 67-78.
20. Kennedy GL, Ferenz RL, Burgess BA. Estimation of acute oral toxicity in rats by determination of the approximate lethal dose rather than the LD. J Appl Toxicol 1986; 6:145-8.
21. Hosseinzadeh H, Sadeghnia HR. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine 2007; 14(4):256-62.
22. Hosseinzadeh H, Noraei NB. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother Res 2009; 23:768-74.