The LIMP-2/SCARB2 binding motif on acid β-Glucosidase: Basic and applied implications for gaucher disease and associated neurodegenerative diseases

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 30063-30074

  Liou, Benjamin ^a,b   Haffey, Wendy D ^c   Greis, Kenneth D ^c   Grabowski, Gregory A ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; NEURODEGENERATIVE DISEASES; PROTEINS;

BETA-GLUCOSIDASE; BINDING SEQUENCE; ENTEROVIRUS 71; EXTERNAL SURFACES; GAUCHER DISEASE; HETEROLOGOUS EXPRESSION; INTEGRAL MEMBRANE PROTEINS; SINGLE ALANINE SUBSTITUTIONS;

BINDING SITES;

ALANINE; ASPARAGINE; ASPARTYLSERYLPROLYLISOLEUCYLISOLEUCYLVALYLASPARTYLISOLEUCYLTHREONYLLYSYLASPARTIC ACID; GLUCOSYLCERAMIDASE; ISOLEUCINE; LYSOSOMAL INTEGRAL MEMBRANE PROTEIN 2; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; AMINE; GREEN FLUORESCENT PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; PEPTIDE; PROTEIN BINDING; RED DND-99; SCARB2 PROTEIN, HUMAN; SCAVENGER RECEPTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE; CRYSTAL STRUCTURE; ENTEROVIRUS 71; ENZYME RELEASE; ENZYME SYNTHESIS; LYSOSOME; PH; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; ANIMAL; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; DEFICIENCY; DEGENERATIVE DISEASE; ENZYMOLOGY; GAUCHER DISEASE; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTAGENESIS; MUTATION; PATHOLOGY; PROTEIN TERTIARY STRUCTURE;

ALANINE; AMINES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING, COMPETITIVE; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; GREEN FLUORESCENT PROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOPRECIPITATION; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; NEURODEGENERATIVE DISEASES; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, SCAVENGER; TRANSFECTION;

EID: 84908190426     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.593616     Document Type: Article

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