A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase

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Volumn 13, Issue 8, 2012, Pages 1113-1123

  Zachos, Christina ^a   Blanz, Judith ^a   Saftig, Paul ^a   Schwake, Michael ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

glucocerebrosidase; Action myoclonus renal failure syndrome; Gaucher disease; LIMP 2; Lysosomal transport; Lysosomes; Progressive myoclonus epilepsy; SCARB2

Indexed keywords

ADENOSINE TRIPHOSPHATASE; GLUCOSYLCERAMIDASE; GLYCOPROTEIN; HISTIDINE; PROTEIN LIMP 2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISSOCIATION; ENZYME BINDING; GAUCHER DISEASE; HUMAN; HUMAN CELL; KIDNEY FAILURE; LYSOSOME MEMBRANE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CODON, NONSENSE; COS CELLS; ENDOSOMES; ENZYME INHIBITORS; FIBROBLASTS; GLUCOSYLCERAMIDASE; HELA CELLS; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MACROLIDES; MICE; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; MYOCLONIC EPILEPSIES, PROGRESSIVE; PROTEIN BINDING; RECEPTORS, SCAVENGER; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84863871382     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/j.1600-0854.2012.01372.x     Document Type: Article

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