Profile of selumetinib and its potential in the treatment of melanoma

OncoTargets and Therapy

Volumn 7, Issue , 2014, Pages 1631-1639

  Kim, Dae Won ^a   Patel, Sapna P ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

MEK inhibitor; Melanoma; Selumetinib; Uveal melanoma

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; AZD 8055; B RAF KINASE; B RAF KINASE INHIBITOR; CEDIRANIB; COBIMETINIB; DABRAFENIB; DACARBAZINE; DOCETAXEL; DOXORUBICIN; ERLOTINIB; GSK 2126468; IRINOTECAN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLACEBO; PROTEIN KINASE B INHIBITOR; SELUMETINIB; SMALL INTERFERING RNA; TEMOZOLOMIDE; TEMSIROLIMUS; TRAMETINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEMURAFENIB; VORINOSTAT; WNT3A PROTEIN;

ABDOMINAL PAIN; ALKALINE PHOSPHATASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; BLOOD TOXICITY; BLURRED VISION; CANCER CELL LINE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CONSTIPATION; DIARRHEA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG DOSAGE FORM COMPARISON; DRUG HALF LIFE; DRUG POTENTIATION; DRUG RESISTANCE; DRUG SELECTIVITY; DRUG SENSITIZATION; DRUG STRUCTURE; DRUG TARGETING; DYSPNEA; ENZYME INHIBITION; EYE TOXICITY; FATIGUE; FOOD; FOOD DRUG INTERACTION; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEART LEFT VENTRICLE FAILURE; HUMAN; HYPERTENSION; HYPOXIA; IC50; INFECTION; MAXIMUM PLASMA CONCENTRATION; MELANOMA; METASTATIC MELANOMA; MONOTHERAPY; MUSCULOSKELETAL DISEASE; NAUSEA; NEUROTOXICITY; NONHUMAN; PERIPHERAL EDEMA; PHARMACODYNAMICS; PNEUMONIA; RASH; REVIEW; SIDE EFFECT; SKIN MANIFESTATION; SUSPENSION; UVEA MELANOMA; VOMITING;

EID: 84908160197     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S51596     Document Type: Review

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