Deficient hippocampal insulin signaling and augmented tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: A study in Zucker rats

BMC Neuroscience

Volumn 15, Issue 1, 2014, Pages

  Špolcová, Andrea ^a   Mikulášková, Barbora ^a   Kršková, Katarína ^b   Gajdošechová, Lucia ^b   Zórad, Štefan ^b   Olszanecki, Rafał ^c   Suski, Maciej ^c   Bujak Gizycka, Beata ^c   Železná, Blanka ^a   Maletínská, Lenka ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

GSK 3 ; Insulin resistance; Obesity; Tau protein; Zucker fa fa rats

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; LEPTIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TAU PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MAPT PROTEIN, RAT;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; GENOTYPE; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; HYPERINSULINEMIA; INSULIN DEFICIENCY; INSULIN RESISTANCE; MALE; NONHUMAN; OBESITY; PROTEIN PHOSPHORYLATION; RAT; RISK ASSESSMENT; RISK FACTOR; SIGNAL TRANSDUCTION; ZUCKER RAT; ANIMAL; GENETICS; GLUCOSE TOLERANCE TEST; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, WESTERN; GLUCOSE TOLERANCE TEST; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; INSULIN; INSULIN RESISTANCE; MALE; OBESITY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS, ZUCKER; SIGNAL TRANSDUCTION; TAU PROTEINS;

EID: 84908131278     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-15-111     Document Type: Article

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