Effect of micronutrient supplementation on treatment outcomes in children with intrathoracic tuberculosis: A randomized controlled trial

American Journal of Clinical Nutrition

Volumn 100, Issue 5, 2014, Pages 1287-1297

  Lodha, Rakesh ^a   Mukherjee, Aparna ^a   Singh, Varinder ^b   Singh, Sarman ^a   Friis, Henrik ^c   Faurholt Jepsen, Daniel ^c   Bhatnagar, Shinjini ^a   Saini, Savita ^a   Kabra, Sushil K ^a   Grewal, Harleen M S ^d   Aneja, S ^e   Arya, Tina ^e   Chandra, J ^e   Dutta, A K ^e   Doherty, T M ^e   Hesseling, A C ^e   Marais, B ^e   Parashar, Deepak ^e   Prajapati, Suneel ^e   Purohit, Kamna ^e   Saini, Deepak ^e   Singh, Ravi Raj ^e   more..

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b KALAWATI SARAN CHILDREN'S HOSPITAL   (India)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF BERGEN   (Norway)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; COPPER; CYANOCOBALAMIN; ETHAMBUTOL; FOLIC ACID; ISONIAZID; NICOTINIC ACID; PLACEBO; PYRAZINAMIDE; PYRIDOXINE; RETINOL; RIBOFLAVIN; RIFAMPICIN; SELENIUM; THIAMINE; TRACE ELEMENT; VITAMIN D; ZINC; TUBERCULOSTATIC AGENT;

ADOLESCENT; ANTIBIOTIC THERAPY; ARM CIRCUMFERENCE; ARTICLE; BODY HEIGHT; BODY MASS; CALORIC INTAKE; CAUSE OF DEATH; CHILD; CONTROLLED STUDY; COPPER BLOOD LEVEL; DOUBLE BLIND PROCEDURE; FACTORIAL DESIGN; FEMALE; FOLLOW UP; HUMAN; INFANT; INTESTINE PERFORATION; INTRATHORACIC TUBERCULOSIS; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MILIARY TUBERCULOSIS; MULTICENTER STUDY; MULTIDRUG RESISTANT TUBERCULOSIS; PATIENT COMPLIANCE; PROTEIN CALORIE MALNUTRITION; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY FAILURE; RICKETS; SECONDARY INFECTION; SEPTIC SHOCK; SEX RATIO; SKINFOLD THICKNESS; SUPERINFECTION; SUPPLEMENTATION; TEACHING HOSPITAL; THORAX RADIOGRAPHY; TREATMENT DURATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; WEIGHT GAIN; ZINC BLOOD LEVEL; BODY WEIGHT; DIET SUPPLEMENTATION; INDIA; PRESCHOOL CHILD; TUBERCULOSIS;

ADOLESCENT; ANTITUBERCULAR AGENTS; BODY HEIGHT; BODY MASS INDEX; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ETHAMBUTOL; FEMALE; HUMANS; INDIA; INFANT; ISONIAZID; MALE; MICRONUTRIENTS; PATIENT COMPLIANCE; PYRAZINAMIDE; RIFAMPIN; TREATMENT OUTCOME; TUBERCULOSIS; ZINC;

EID: 84908129454     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.113.082255     Document Type: Article

References (48)

1. Ströhle A, Wolters M, Hahn A. Micronutrients at the interface between inflammation and infection-ascorbic acid and calciferol. Part 2: calciferol and the significance of nutrient supplements. Inflamm Allergy Drug Targets 2011;10:64-74.
2. Ströhle A, Wolters M, Hahn A. Micronutrients at the interface between inflammation and infection-ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. Inflamm Allergy Drug Targets 2011;10:54-63.
3. Taylor CE, Camargo CA Jr. Impact of micronutrients on respiratory infections. Nutr Rev 2011;69:259-69.
4. Gunville CF, Mourani PM, Ginde AA. The role of vitamin D in prevention and treatment of infection. Inflamm Allergy Drug Targets 2013;12:239-45.
5. Yakoob MY, Theodoratou E, Jabeen A, Imdad A, Eisele TP, Ferguson J, Jhass A, Rudan I, Campbell H, Black RE, et al. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health 2011;11(suppl 3):S23.
6. Ross AC. Vitamin A and retinoic acid in T cell-related immunity. Am J Clin Nutr 2012;96:1166S-72S.
7. WHO. TB Report, 1996. Geneva, Switzerland: World Health Organization, 1996.
8. Cegielski JP, McMurray DN. The relationship between malnutrition and tuberculosis: evidence from studies in humans and experimental animals. Int J Tuberc Lung Dis 2004;8:286-98.
9. Byrd RP Jr, Mehta JB, Roy TM. Malnutrition and pulmonary tuberculosis. Clin Infect Dis 2002;35:634-5.
10. Koh GC, Hawthorne G, Turner AM, Kunst H, Dedicoat M. Tuberculosis incidence correlates with sunshine: an ecological 28-year time series study. PLoS ONE 2013;8:e57752.
11. Gray K, Wood N, Gunasekera H, Sheikh M, Hazelton B, Barzi F, Isaacs D. Vitamin d and tuberculosis status in refugee children. Pediatr Infect Dis J 2012;31:521-23.
12. Talat N, Perry S, Parsonnet J, Dawood G, Hussain R. Vitamin D deficiency and tuberculosis progression. Emerg Infect Dis 2010;16:853-5.
13. Williams B, Williams AJ, Anderson ST. Vitamin D deficiency and insufficiency in children with tuberculosis. Pediatr Infect Dis J 2008;27:941-2.
14. Sita-Lumsden A, Lapthorn G, Swaminathan R, Milburn HJ. Reactivation of tuberculosis and vitamin D deficiency: the contribution of diet and exposure to sunlight. Thorax 2007;62:1003-7.
15. Friis H, Range N, Changalucha J, Praygod G, Jeremiah K, Faurholt-Jepsen D, Krarup H, Mølgaard C, Andersen AB, Vitamin D. Status among pulmonary TB patients and non-TB controls: a cross-sectional study from Mwanza, Tanzania. PLoS ONE 2013;8:e81142.
16. Salahuddin N, Ali F, Hasan Z, Rao N, Aqeel M, Mahmood F. Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis'. BMC Infect Dis 2013;13:22.
17. Ganmaa D, Giovannucci E, Bloom BR, Fawzi W, Burr W, Batbaatar D, Sumberzul N, Holick MF, Willett WC. Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial. Am J Clin Nutr 2012;96:391-6.
18. Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, Packe GE, Moore-Gillon JC, Darmalingam M, Davidson RN, et al. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 2011;377:242-50.
19. Wejse C, Gomes VF, Rabna P, Gustafson P, Aaby P, Lisse IM, Andersen PL, Glerup H, Sodemann M. Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 2009;179:843-50.
20. Ralph AP, Waramori G, Pontororing GJ, Kenangalem E, Wiguna A, Tjitra E, Sandjaja, Lolong DB, Yeo TW, Chatfield MD, et al. L-arginine and vitamin D adjunctive therapies in pulmonary tuberculosis: a randomised, double-blind, placebo-controlled trial. PLoS ONE 2013;8:e70032.
21. Karyadi E, West CE, Schultink W, Nelwan RH, Gross R, Amin Z, Dolmans WM, Schlebusch H, van der Meer JW. A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: effects on clinical response and nutritional status. Am J Clin Nutr 2002;75:720-7.
22. Range N, Changalucha J, Krarup H, Magnussen P, Andersen AB, Friis H. The effect of multi-vitamin/mineral supplementation on mortality during treatment of pulmonary tuberculosis: a randomized two-by-two factorial trial in Mwanza, Tanzania. Br J Nutr 2006;95:762-70.
23. Mehta S, Mugusi FM, Bosch RJ, Aboud S, Chatterjee A, Finkelstein JL, Fataki M, Kisenge R, Fawzi WW. A randomized trial of multivitamin supplementation in children with tuberculosis in Tanzania. Nutr J 2011;10:120.
24. Migliori GB, Borghesi A, Rossanigo P, Adriko C, Neri M, Santini S, Bartoloni A, Paradisi F, Acocella Gl. Proposal of an improved score method for the diagnosis of pulmonary tuberculosis in childhood in developing countries. Tuber Lung Dis 1992;73:145-9.
25. Chauhan LS, Arora VK; Central TB Division, Directorate General of Health Services, Ministry of Health and Family Welfare; Indian Academy of Pediatrics. Management of pediatric tuberculosis under the Revised National Tuberculosis Control Program (RNTCP). Indian Pediatr 2004;41:901-5.
26. Kabra SK, Lodha R, Seth V. Category based treatment of tuberculosis in children. Indian Pediatr 2004;41:927-37.
27. Expert group of Indian Council of Medical Research. Nutrient requirements and Recommended Dietary Allowances for Indians. Hyderabad, India: Indian Council of Medical Research, 1990.
28. Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS). NHANES - National Health and Nutrition Examination Survey homepage. 2005. Available from: http://www.cdc.gov/NCHS/nhanes.htm (cited 4 March 2013).
29. Mukherjee A, Singh S, Lodha R, Singh V, Hesseling A, Grewal HM, Kabra S. for the Delhi Pediatric TB Study Group. Ambulatory gastric lavages provide better yields of Mycobacterium tuberculosis than induced sputum in children with intra-thoracic tuberculosis. Pediatr Infect Dis J 2013;32:1313-7.
30. Cellestis. QuantiFERON - TB Gold In-Tube. Available from: http://www.cellestis.com/irm/content/aust/qtfproducts-tbgoldintube.html (cited 16 October 2013).
31. de Benoist B, Darnton-Hill I, Davidsson L, Fontaine O, Hotz C. Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG Interagency Meeting on Zinc Status Indicators. Food Nutr Bull 2007;28:S480-4.
32. Seth V, Kabra SK. Pulmonary tuberculosis. In: Seth V, Kabra SK, eds. Essentials of Tuberculosis in Children. New Delhi: Jaypee, 2010:101-21.
33. McAlister FA, Straus SE, Sackett DL, Altman DG. Analysis and reporting of factorial trials: a systematic review. JAMA 2003;289:2545-53.
34. Nenni V, Nataprawira HM, Yuniati T. Role of combined zinc, vitamin A, and fish oil supplementation in childhood tuberculosis. Southeast Asian J Trop Med Public Health 2013;44:854-61.
35. Paton NI, Chua YK, Earnest A, Chee CB. Randomized controlled trial of nutritional supplementation in patients with newly diagnosed tuberculosis and wasting. Am J Clin Nutr 2004;80:460-5.
36. PrayGod G, Range N, Faurholt-Jepsen D, Jeremiah K, Faurholt-Jepsen M, Aabye MG, Jensen L, Jensen AV, Grewal HM, Magnussen P, et al. Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV-uninfected but not HIV-infected patients in Mwanza, Tanzania. J Nutr 2011;141:685-91.
37. Pakasi TA, Karyadi E, Suratih NM, Salean M, Darmawidjaja N, Bor H, van der Velden K, Dolmans WM, van der Meer JW. Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia. Nutr J 2010;9:41.
38. Visser ME, Grewal HM, Swart EC, Dhansay MA, Walzl G, Swanevelder S, Lombard C, Maartens G. The effect of vitamin A and zinc supplementation on treatment outcomes in pulmonary tuberculosis: a randomized controlled trial. Am J Clin Nutr 2011;93:93-100.
39. Guideline WHO. Nutritional care and support for patients with tuberculosis. Geneva, Switzerland: World Health Organization, 2013.
40. Friis H. Micronutrient interventions and HIV infection: a review of current evidence. Trop Med Int Health 2006;11:1849-57.
41. Ramakrishnan U, Nguyen P, Martorell R. Effects of micronutrients on growth of children under 5 y of age: meta-analyses of single and multiple nutrient interventions. Am J Clin Nutr 2009;89:191-203.
42. Brown KH, Peerson JM, Rivera J, Allen LH. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2002;75:1062-71.
43. Abba K, Sudarsanam TD, Grobler L, Volmink J. Nutritional supplements for people being treated for active tuberculosis. Cochrane Database Syst Rev 2008;4:CD006086.
44. Sinclair D, Abba K, Grobler L, Sudarsanam TD. Nutritional supplements for people being treated for active tuberculosis. Cochrane Database Syst Rev 2011;11:CD006086.
45. Cernat RI, Mihaescu T, Vornicu M, Vione D, Olariu RI, Arsene C. Serum trace metal and ceruloplasmin variability in individuals treated for pulmonary tuberculosis. Int J Tuberc Lung Dis 2011;15:1239-45.
46. Kawai K, Meydani SN, Urassa W, Wu D, Mugusi FM, Saathoff E, Bosch RJ, Villamor E, Spiegelman D, Fawzi WW. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiol Infect 2014;142:1505-9.
47. Bada C, Carreazo NY, Chalco JP, Huicho L. Inter-observer agreement in interpreting chest X-rays on children with acute lower respiratory tract infections and concurrent wheezing. Sao Paulo Med J 2007;125:150-4.
48. Patel AB, Amin A, Sortey SZ, Athawale A, Kulkarni H. Impact of training on observer variation in chest radiographs of children with severe pneumonia. Indian Pediatr 2007;44:675-81.