Vitamin D, tuberculinskin test conversion, and latent tuberculosis in Mongolian school-age children: A randomized, double-blind, placebo-controlled feasibility trial

American Journal of Clinical Nutrition

Volumn 96, Issue 2, 2012, Pages 391-396

  Ganmaa, Davaasambuu ^a,b   Giovannucci, Edward ^a   Bloom, Barry R ^c   Fawzi, Wafaie ^c   Burr, Winthrop ^b,d   Batbaatar, Dulguun ^b   Sumberzul, Nyamjav ^b   Holick, Michael F ^e   Willett, Walter C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MONGOLIAN NATIONAL UNIVERSITY OF MEDICAL SCIENCES   (Mongolia)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD UNIVERSITY   (United States)

^e BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; BCG VACCINE; COLECALCIFEROL; GAMMA INTERFERON; PLACEBO; TUBERCULIN; VITAMIN D;

ADOLESCENT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BCG VACCINATION; BODY WEIGHT; CHEMOLUMINESCENCE; CHILD; CHILD GROWTH; CHILD NUTRITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HOST RESISTANCE; HUMAN; IMMUNOASSAY; LATENT TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MONGOLIA; MYCOBACTERIUM TUBERCULOSIS; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SKIN TEST; T LYMPHOCYTE; TREATMENT OUTCOME; TUBERCULIN TEST; TUBERCULOSIS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN INTAKE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; FEASIBILITY STUDY; METHODOLOGY;

BACTERIA (MICROORGANISMS);

ADOLESCENT; CHILD; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEASIBILITY STUDIES; FEMALE; HUMANS; LATENT TUBERCULOSIS; MALE; MONGOLIA; TUBERCULIN TEST; VITAMIN D;

EID: 84864364611     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.112.034967     Document Type: Article

References (31)

1. Global Tuberculosis Control WHO. 2010. Available from: http:// whqlibdoc.who.int/publications/2010/9789241564069-eng.pdf (cited 11 January 2012).
2. Bloom BR, Murray CJL. Tuberculosis: commentary on a reemergent killer. Science 1992;257:1055-64.
3. Ganmaa D, Tserendolgor U, Frazier L, Nakamoto E, Jargalsaikhan N, Rich-Edwards J. Effects of vitamin D fortified milk on vitamin D status in Mongolian school age children. Asia Pac J Clin Nutr 2008;17:68-71.
4. Agarwal KS, Mughal MZ, Upadhyay P, Berry JL, Mawer EB, Puliyel JM. The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India. Arch Dis Child 2002;87:111-3. (Pubitemid 34828014)
5. Martineau AR, Wilkinson R, Wilkinson K, Newton S, Kampmann B, Hall B, Packe G, Davidson R, Eldridge S, Maunsell Z, et al. A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med 2007;176:208-13. (Pubitemid 47057859)
6. Davies PDO. A possible link between vitamin D deficiency and impaired host defence to Mycobacterium tuberculosis. Tubercle 1985;66:301-6. (Pubitemid 16203099)
7. Chan TY. Seasonal variations in vitamin-D status and the incidence of tuberculosis in different countries. Respiration 1999;66:196. (Pubitemid 29161146)
8. Bellamy R. Identifying genetic susceptibility factors for tuberculosis in Africans: a combined approach using a candidate gene study and a genome-wide screen. Clin Sci (Lond) 2000;98:245-50. (Pubitemid 30145229)
9. Wilkinson RJ, Llewelyn M, Toossi Z, Patel P, Pasvol G, Lalvani A, Wright D, Latif M, Davidson RN. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet 2000;355:618-21. (Pubitemid 30099469)
10. Gibney KB, MacGregor L, Leder K, Torresi J, Marshall C, Ebeling PR, Biggs BA. Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa. Clin Infect Dis 2008;46:443-6. (Pubitemid 351263529)
11. Arnedo-Pena A, Juan-Cerdan JV, Romeu-Gracia A, Garcia-Ferrer D, Holguin-Gomez R, Iborra-Millet J, Herrero-Carot C, Sanchis-Pinana J, Bellido-Blasco J, Ferrero-Vega JA, et al. Latent tuberculosis infection, tuberculin skin test conversion and vitamin D status in contacts of tuberculosis patients: a cross-sectional and case-control study. BMC Infect Dis 2011;11:349.
12. Rockett KA, Brookes R, Udalova I, Vidal V, Hill AV, Kwiatkowski D. 1,25-dihydroxyvitamin D3, induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line. Infect Immun 1998;66:5314-21. (Pubitemid 29044625)
13. Rook GA, Steele J, Fraher L, Barker S, Karmali R, O'Riordan J, Stanford J. Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 1986;57:159-63. (Pubitemid 16232232)
14. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311:1770-3.
15. Gibson RS. Principles of nutritional assessment. New York, NY: Oxford University Press, 1990:187-208.
16. Barnes PF. Weighing gold or counting spots: which is more sensitive to diagnose latent tuberculosis infection? Am J Respir Crit Care Med 2006; 174:731-2. (Pubitemid 44511651)
17. Gordon CM, DePeter K, Feldman HA, Grace E, Emans J. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 2004;158:531-7. (Pubitemid 38720483)
18. Docio S, Riancho J, Perez A, Olmos J, Amado J, Gonzalez-Macias J. Seasonal deficiency of Vitamin D in children: a potential target for osteoporosis-preventing strategies? J Bone Miner Res 1998;13: 544-8. (Pubitemid 28163005)
19. Rich-Edwards JW, Ganmaa D, Pollak MN, Nakamoto EK, Kleinman K, Tserendolgor U, Willett WC, Frazier AL. Milk consumption and the prepubertal somatotropic axis. Nutr J 2007;6:28.
20. Gelander L, Karlberg J, Albertsson-Wikland K. Seasonality in lower leg length velocity in prepubertal chidlren. Acta Paediatr 1994;83: 1249-54.
21. Mirwald RL, Bailey DA. Seasonal height velocity variation in boys and girls. Am J Hum Biol 1997;9:709-15. (Pubitemid 127466788)
22. Palmer CE. Seasonal variation in average growth in weight of elementary school children. Public Health Rep 1933;48:211-42.
23. Bogin B. Monthly changes in the gain and loss of growth in weight of children living in Guatemala. Am J Phys Anthropol 1979;51: 287-91.
24. Bogin BA. Seasonal pattern in the rate of growth in height of children living in Guatemala. Am J Phys Anthropol 1978;49:205-10. (Pubitemid 9009667)
25. Marshall WA, Swan AV. Seasonal variation in growth rates of normal and blind children. Hum Biol 1971;43:502-16.
26. Talat N, Perry S, Parsonnet J, Dawood G, Hussain R, Vitamin D. Deficiency and tuberculosis progression. Emerg Infect Dis 2010;16: 853-5.
27. Menzies D. What does tuberculin reactivity after Bacille Calmette- Guérin vaccination tell us? Clin Infect Dis 2000;31(suppl):S71-4. (Pubitemid 32269592)
28. Toss G, Symreng T. Delayed hypersensitivity response and vitamin D deficiency. Int J Vitam Nutr Res 1983;53:27-31. (Pubitemid 13135081)
29. Nielsen NO, Skifte T, Andersson M, Wohlfahrt J, Søborg B, Koch A, Melbye M, Ladefoged K. Both high and low serum vitamin D concentrations are associated with tuberculosis: a case-control study in Greenland. Br J Nutr 2010;104(10):1487-91.
30. Yesudian PD, Berry JL, Wiles S, Hoyle S, Young DB, Haylett AK, Rhodes LE, Davies P. The effect of ultraviolet B-induced vitamin D levels on host resistance to Mycobacterium tuberculosis: a pilot study in immigrant Asian adults living in the United Kingdom. Photodermatol Photoimmunol Photomed 2008;24:97-8. (Pubitemid 351436832)
31. Holick MF, Chen TC, Vitamin D. Deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080S-6S. (Pubitemid 351549267)