Myocardial atrophy and chronic mechanical unloading of the failing human heart: Implications for cardiac assist device-induced myocardial recovery

Journal of the American College of Cardiology

Volumn 64, Issue 15, 2014, Pages 1602-1612

  Diakos, Nikolaos A ^a,b   Selzman, Craig H ^a,b   Sachse, Frank B ^b   Stehlik, Josef ^a   Kfoury, Abdallah G ^a   Wever Pinzon, Omar ^a   Catino, Anna ^a   Alharethi, Rami ^a   Reid, Bruce B ^a   Miller, Dylan V ^a,c   Salama, Mohamed ^c   Zaitsev, Alexey V ^b   Shibayama, Junko ^b   Li, Hui ^b   Fang, James C ^a   Li, Dean Y ^b   Drakos, Stavros G ^a,b  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c ARUP LABORATORIES   (United States)

Author keywords

left ventricular assist device; mechanical unloading; myocardial atrophy

Indexed keywords

GLYCOGEN; PROTEASOME; RYANODINE RECEPTOR; UBIQUITIN; RNA;

ADULT; ARTICLE; CELL SIZE; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOPLASM; DISEASE ASSOCIATION; ELECTRON MICROSCOPY; FEMALE; GENE EXPRESSION REGULATION; GLYCOGEN ANALYSIS; HEART DISEASE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART MUSCLE ATROPHY; HEART MUSCLE CELL; HEART VENTRICLE REMODELING; HUMAN; HUMAN TISSUE; INTERVENTIONAL CARDIOVASCULAR PROCEDURE; ISCHEMIC CARDIOMYOPATHY; LEFT VENTRICULAR ASSIST DEVICE; MALE; MECHANICAL UNLOADING; NONISCHEMIC CARDIOMYOPATHY; PROSPECTIVE STUDY; PROTEIN EXPRESSION; TRANSVERSE TUBULAR SYSTEM; TREATMENT DURATION; TREATMENT OUTCOME; ATROPHY; BIOSYNTHESIS; CARDIOMYOPATHIES; CLINICAL TRIAL; COMPLICATION; CONFOCAL MICROSCOPY; CONVALESCENCE; ECHOCARDIOGRAPHY; ECHOGRAPHY; FOLLOW UP; GENETICS; HEART ASSIST DEVICE; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART VENTRICLE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; ULTRASTRUCTURE; UPREGULATION; WESTERN BLOTTING;

ATROPHY; BLOTTING, WESTERN; CARDIOMYOPATHIES; ECHOCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HEART VENTRICLES; HEART-ASSIST DEVICES; HUMANS; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIUM; PROGNOSIS; PROSPECTIVE STUDIES; REAL-TIME POLYMERASE CHAIN REACTION; RECOVERY OF FUNCTION; RNA; UBIQUITIN; UP-REGULATION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84908127009     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2014.05.073     Document Type: Article

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