Characterization of right ventricular remodeling and failure in a chronic pulmonary hypertension model

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 8, 2014, Pages H1204-H1215

  Aguero, Jaume ^a,b   Ishikawa, Kiyotake ^a   Hadri, Lahouaria ^a   Santos Gallego, Carlos ^a   Fish, Kenneth ^a   Hammoudi, Nadjib ^a   Chaanine, Antoine ^a   Torquato, Samantha ^c   Naim, Charbel ^a   Ibanez, Borja ^b   Pereda, Daniel ^b   García Alvarez, Ana ^b   Fuster, Valentin ^a,b   Sengupta, Partho P ^a   Leopold, Jane A ^c   Hajjar, Roger J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Aldosterone; Echocardiography; Pressure volume relationships; Pulmonary hypertension model; Right ventricular remodeling; SERCA2a

Indexed keywords

SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOPULMONARY HEMODYNAMICS; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; ECHOCARDIOGRAPHY; ENDOPLASMIC RETICULUM; HEART FAILURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE REMODELING; HYPERALDOSTERONISM; LUNG PRESSURE; NONHUMAN; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; PULMONARY VEIN; VASCULAR RESISTANCE; YORKSHIRE PIG; ANIMAL; CARDIOMEGALY; ENDOPLASMIC RETICULUM STRESS; FIBROSIS; GENETICS; HEART CONTRACTION; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; HEMODYNAMICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PULMONARY ARTERY; SWINE;

ANIMALS; CARDIOMEGALY; ENDOPLASMIC RETICULUM STRESS; FIBROSIS; HEART VENTRICLES; HEMODYNAMICS; HYPERTENSION, PULMONARY; MYOCARDIAL CONTRACTION; PULMONARY ARTERY; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SWINE; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR REMODELING;

EID: 84908101867     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00246.2014     Document Type: Article

References (45)

1. Archer SL, Fang YH, Ryan JJ, Piao L. Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension. Pulm Circ 3: 144-152, 2013.
2. Benza RL, Miller DP, Gomberg-Maitland M, Frantz RP, Foreman AJ, Coffey CS, Frost A, Barst RJ, Badesch DB, Elliott CG, Liou TG, McGoon MD. Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 122: 164-172, 2010.
3. Bogaard HJ, Abe K, Vonk Noordegraaf A, Voelkel NF. The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. CHEST J 135: 794-804, 2009.
4. Brimioulle S, Wauthy P, Ewalenko P, Rondelet B, Vermeulen F, Kerbaul F, Naeije R. Single-beat estimation of right ventricular endsystolic pressure-volume relationship. Am J Physiol Heart Circ Physiol 284: H1625-H1630, 2003.
5. Burke MA, Katz DH, Beussink L, Selvaraj S, Gupta DK, Fox J, Chakrabarti S, Sauer AJ, Rich JD, Freed BH, Shah SJ. Prognostic importance of pathophysiologic markers in patients with heart failure and preserved ejection fraction. Circ Heart Fail 7: 288-299, 2014.
6. Burkhoff D, Mirsky I, Suga H. Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers. Am J Physiol Heart Circ Physiol 289: H501-H512, 2005.
7. Crean AM, Maredia N, Ballard G, Menezes R, Wharton G, Forster J, Greenwood JP, Thomson JD. 3D echo systematically underestimates right ventricular volumes compared to cardiovascular magnetic resonance in adult congenital heart disease patients with moderate or severe RV dilatation. J Cardiovasc Magn Reson 13: 78, 2011.
8. Dell'Italia LJ, Walsh RA. Application of a time varying elastance model to right ventricular performance in man. Cardiovasc Res 22: 864-874, 1988.
9. Dickstein ML, Yano O, Spotnitz HM, Burkhoff D. Assessment of right ventricular contractile state with the conductance catheter technique in the pig. Cardiovasc Res 29: 820-826, 1995.
10. Drake JI, Bogaard HJ, Mizuno S, Clifton B, Xie B, Gao Y, Dumur CI, Fawcett P, Voelkel NF, Natarajan R. Molecular signature of a right heart failure program in chronic severe pulmonary hypertension. Am J Resp Cell Mol Biol 45: 1239-1247, 2011.
11. Fine NM, Chen L, Bastiansen PM, Frantz RP, Pellikka PA, Oh JK, Kane GC. Outcome prediction by quantitative right ventricular function assessment in 575 subjects evaluated for pulmonary hypertension. Circ Cardiovasc Imaging 6: 711-721, 2013.
12. Forfia PR, Vachiéry JL. Echocardiography in pulmonary arterial hypertension. Am J Card 110: S16-S24, 2012.
13. Fukuda Y, Tanaka H, Sugiyama D, Ryo K, Onishi T, Fukuya H, Nogami M, Ohno Y, Emoto N, Kawai H, Hirata KI. Utility of right ventricular free wall speckle-tracking strain for evaluation of right ventricular performance in patients with pulmonary hypertension. J Am Soc Echocardiogr 24: 1101-1108, 2011.
14. Galie N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA, Beghetti M, Corris P, Gaine S, Gibbs JS, Gomez-Sanchez MA, Jondeau G, Klepetko W, Opitz C, Peacock A, Rubin L, Zellweger M, Simonneau G. Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J 30: 2493-2537, 2009.
15. Geyer H, Caracciolo G, Abe H, Wilansky S, Carerj S, Gentile F, Nesser HJ, Khandheria B, Narula J, Sengupta PP. Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J Am Soc Echocardiogr 23: 351-369, 2010.
16. Glembotski CC. Endoplasmic reticulum stress in the heart. Circ Res 101: 975-984, 2007.
17. Gómez A, Bialostozky D, Zajarias A, Santos E, Palomar A, Martínez MAL, Sandoval J. Right ventricular ischemia in patients with primary pulmonary hypertension. J Am Coll Card 38: 1137-1142, 2001.
18. Gomez-Arroyo J, Saleem SJ, Mizuno S, Syed AA, Bogaard HJ, Abbate A, Taraseviciene-Stewart L, Sung Y, Kraskauskas D, Farkas D, Conrad DH, Nicolls MR, Voelkel NF. A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects. Am J Physiol Lung Cell Mol Physiol 302: L977-L991, 2012.
19. Guihaire J, Haddad F, Boulate D, Decante B, Denault AY, Wu J, Hervé P, Humbert M, Dartevelle P, Verhoye JP, Mercier O, Fadel E. Non-invasive indices of right ventricular function are markers of ventricular-arterial coupling rather than ventricular contractility: insights from a porcine model of chronic pressure overload. Eur Heart J Cardiovasc Imaging 14: 1140-1149, 2013.
20. Guihaire J, Haddad F, Boulate D, Capderou A, Decante B, Flécher E, Eddahibi S, Dorfmüller P, Hervé P, Humbert M, Verhoye JP, Dartevelle P, Mercier O, Fadel E. Right ventricular plasticity in a porcine model of chronic pressure overload. J Heart Lung Transplant 33: 194-202, 2014.
21. Hadri L, Kratlian RG, Benard L, Maron BA, Dorfmuller P, Ladage D, Guignabert C, Ishikawa K, Aguero J, Ibanez B, Turnbull IC, Kohlbrenner E, Liang L, Zsebo K, Humbert M, Hulot JS, Kawase Y, Hajjar RJ, Leopold JA. Therapeutic efficacy of AAV1. SERCA2a in monocrotaline-induced pulmonary arterial hypertension. Circulation 128: 512-523, 2013.
22. Haeck MLA, Scherptong RWC, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Vliegen HW, Delgado V. Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension. Circ Cardiovasc Imaging 5: 628-636, 2012.
23. Ibrahim T, Nekolla SG, Schreiber K, Odaka K, Volz S, Mehilli J, Güthlin M, Delius W, Schwaiger M. Assessment of coronary flow reserve: comparison between contrast-enhanced magnetic resonance imaging and positron emission tomography. J Am Coll Cardiol 39: 864-870, 2002.
24. Kelley KW, Curtis SE, Marzan GT, Karara HM, Anderson CR. Body surface area of female swine. J Anim Sci 36: 927-930, 1973.
25. Khush KK, Tasissa G, Butler J, McGlothlin D, De Marco T; Investigators ESCAPE. Effect of pulmonary hypertension on clinical outcomes in advanced heart failure: analysis of the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) database. Am Heart J 157: 1026-1034, 2009.
26. Kuehne T, Yilmaz S, Steendijk P, Moore P, Groenink M, Saaed M, Weber O, Higgins CB, Ewert P, Fleck E, Nagel E, Schulze-Neick I, Lange P. Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension. Circulation 110: 2010-2016, 2004.
27. Mahapatra S, Nishimura RA, Sorajja P, Cha S, McGoon MD. Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension. J Am Coll Cardiol 47: 799-803, 2006.
28. Maron BA, Opotowsky AR, Landzberg MJ, Loscalzo J, Waxman AB, Leopold JA. Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. Eur J Heart Fail 15: 277-283, 2013.
29. Maron BA, Waxman AB, Opotowsky AR, Gillies H, Blair C, Aghamohammadzadeh R, Loscalzo J, Leopold JA. Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] Study 1 and 2 Trials). Am J Card 112: 720-725, 2013.
30. Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. Aldosterone inactivates the endothelin-b receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation 126: 963-974, 2012.
31. Moon MR, Aziz A, Lee AM, Moon CJ, Okada S, Kanter EM, Yamada KA. Differential calcium handling in two canine models of right ventricular pressure overload. J Surg Res 178: 554-562, 2012.
32. Morikawa T, Murata M, Okuda S, Tsuruta H, Iwanaga S, Satoh T, Ogawa S, Fukuda K. Quantitative analysis of right ventricular function in patients with pulmonary hypertension using three-dimensional echocardiography and a two-dimensional summation method compared to magnetic resonance imaging. Am J Cardiol 107: 484-489, 2011.
33. Pereda D, García-Alvarez A, Sánchez-Quintana D, Nuño M, Fernández-Friera L, Fernández-Jiménez R, García-Ruíz J, Sandoval E, Aguero J, Castellá M, Hajjar R, Fuster V, Ibáñez B. Swine model of chronic postcapillary pulmonary hypertension with right ventricular remodeling: long-term characterization by cardiac catheterization, magnetic resonance, and pathology. J Cardiovasc Transl Res 7: 494-506, 2014.
34. Rondelet B, Dewachter C, Kerbaul F, Kang X, Fesler P, Brimioulle S, Naeije R, Dewachter L. Prolonged overcirculation-induced pulmonary arterial hypertension as a cause of right ventricular failure. Eur Heart J 33: 1017-1026, 2012.
35. Rondelet B, Kerbaul F, Motte S, van Beneden R, Remmelink M, Brimioulle S, McEntee K, Wauthy P, Salmon I, Ketelslegers JM, Naeije R. Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension. Circulation 107: 1329-1335, 2003.
36. Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, Solomon SD, Louie EK, Schiller NB. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 23: 685-713, 2010.
37. Sachdev A, Villarraga HR, Frantz RP, McGoon MD, Hsiao JF, Maalouf JF, Ammash NM, McCully RB, Miller FA, Pellikka PA, Oh JK, Kane GC. Right ventricular strain for prediction of survival in patients with pulmonary arterial hypertension. Chest J 139: 1299-1309, 2011.
38. Sanz J, García-Alvarez A, Fernández-Friera L, Nair A, Mirelis JG, Sawit ST, Pinney S, Fuster V. Right ventriculo-arterial coupling in pulmonary hypertension: a magnetic resonance study. Heart 98: 238-243, 2012.
39. Silove ED, Tavernor WD, Berry CL. Reactive pulmonary arterial hypertension after pulmonary venous constriction in the calf. Cardiovasc Res 6: 36-44, 1972.
40. Stevens GR, Garcia-Alvarez A, Sahni S, Garcia MJ, Fuster V, Sanz J. RV dysfunction in pulmonary hypertension is independently related to pulmonary artery stiffness. J Am Coll Cardiol Cardiovasc Imaging 5: 378-387, 2012.
41. Sutendra G, Michelakis ED. Pulmonary arterial hypertension: challenges in translational research and a vision for change. Sci Transl Med 5: 208sr5, 2013.
42. Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED. The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med 3: 88, 2012.
43. Vachiéry JL, Adir Y, Barberà JA, Champion H, Coghlan JG, Cottin V, De Marco T, Galiè N, Ghio S, Gibbs JSR, Martinez F, Semigran M, Simonneau G, Wells A, Seeger W. Pulmonary hypertension due to left heart diseases. J Am Coll Cardiol 62: D100-D108, 2013.
44. Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, Long CS, Rubin LJ, Smart FW, Suzuki YJ, Gladwin M, Denholm EM, Gail DB. Right ventricular function and failure: report of a national heart, lung, and blood institute working group on cellular and molecular mechanisms of right heart failure. Circulation 114: 1883-1891, 2006.
45. Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM. Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. J Am Coll Cardiol 62: D22-D33, 2013.