Experiment and modeling for the separation of guaifenesin enantiomers using simulated moving bed and Varicol units

Journal of Chromatography A

Volumn 1363, Issue , 2014, Pages 242-249

  Gong, Rujin ^a   Lin, Xiaojian ^a   Li, Ping ^a   Yu, Jianguo ^a   Rodrigues, Alirio E ^b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Chiral separation; Guaifenesin enantiomers; Modeling; SMB process; Varicol process

Indexed keywords

CHIRALITY; DISPERSIONS; ENANTIOMERS; HEXANE; MASS TRANSFER; MODELS;

3 ,5-DIMETHYLPHENYLCARBAMATE; CHIRAL SEPARATIONS; GUAIFENESIN; MASS TRANSFER RESISTANCES; SEPARATION PERFORMANCE; SIMULATED MOVING BED; SIMULATED MOVING BED PROCESS; VARICOL PROCESS;

SEPARATION;

ALCOHOL; CARBAMIC ACID DERIVATIVE; CELLULOSE TRIS 3,5 DIMETHYLPHENYLCARBAMATE; GUAIFENESIN; HEXANE; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; CHIRALITY; ENANTIOMER; FILM; ISOTHERM; MATHEMATICAL MODEL; SEPARATION TECHNIQUE; SIMULATED MOVING BED PROCESS; SIMULATION; VARICOL PROCESS; CHEMISTRY; STEREOISOMERISM; THEORETICAL MODEL;

GUAIFENESIN; MODELS, THEORETICAL; STEREOISOMERISM;

EID: 84908085352     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.06.098     Document Type: Article

References (36)

1. Juza M., Mazzotti M., Morbidelli M. Trends Biotechnol. 2000, 18:108.
2. Goncalves C.V., Carpes M.J.S., Correia C.R.D., Santana C.C. Biochem. Eng. J. 2008, 40:526.
3. Seidel-Morgenstern A., Keßler L.C., Kaspereit M. Chem. Eng. Technol. 2008, 31:826.
4. Gomes P.S., Rodrigues A.E. Chem. Eng. Technol. 2012, 35:17.
5. Shem B., Che M.J., Jiang H.L., Zhao Y.X., Wei F. Sep. Sci. Technol. 2011, 46:695.
6. Mun S.Y. Ind. Eng. Chem. Res. 2010, 49:9258.
7. Mun S.Y. J. Liq. Chromatogr. Related Technol. 2008, 31:1231.
8. Wankat C.P. Ind. Eng. Chem. Res. 2001, 40:6185.
9. Kim J.K., Zang Y.F., Wankat P.C. Ind. Eng. Chem. Res. 2003, 42:4849.
10. Mata V.G., Rodrigues A.E. J. Chromatogr. A 2001, 939:23.
11. Lee J.W., Wankat P.C. J. Chromatogr. A 2010, 1217:3418.
12. Nowak J., Antos D., Seidel-Morgenstern A. J. Chromatogr. A 2012, 1253:58.
13. Borges E.A., Silva D., Rodrigues A.E. Sep. Sci. Technol. 2008, 43:533.
14. Pais L.S., Rodrigues A.E. J. Chromatogr. A 2003, 1006:33.
15. Toumi A., Engell S., Ludemann-Hombourger O., Nicoud R.M., Bailly M. J. Chromatogr. A 2003, 1006:15.
16. Silva A.C., Salles A.G., Perna R.F., Correia C.R.D., Santana C.C. Chem. Eng. Technol. 2012, 35:83.
17. Ludemann-Hombourger O., Nicoud R.M. Sep. Sci. Technol. 2000, 35:1829.
18. Rodrigues R.C.R., Araujo J.M.M., Eusebio M.F.J., Mota J.P.B. J. Chromatogr. A 2007, 1142:69.
19. Rodrigues R.C.R., Araujo J.M.M., Eusebio M.F.J., Mota J.P.B. J. Chromatogr. A 2007, 1162:14.
20. W.P. Shum, H. Mazurek, J. Chen, Process for producing enantiomerically enriched guaifenesin, EP0704420 A1, 1996.
21. Gomes P.S., Zabkova M., Zabka M., Minceva M., Rodrigues A.E. AIChE J. 2010, 56:125.
22. Francotte E.R., Richert P. J. Chromatogr. A 1997, 769:101.
23. Li P., Xiu G.H., Rodrigues A.E. AIChE J. 2007, 5:2419.
24. Li P., Xiu G.H., Rodrigues A.E. Sep. Sci. Technol. 2008, 43:11.
25. Mihlbachler K., Seidel-Morgenstern A., Guichon G. AIChE J. 2004, 50:611.
26. Zhang Y., Hidajat K., Ray A.K. Sep. Purif. Technol. 2009, 65:311.
27. Zabka M., Minceva M., Gomes P.S., Rodrigues A.E. Sep. Sci. Technol. 2008, 43:727.
28. Rodrigues A.E., Pais L.S. Sep. Sci. Technol. 2005, 39:245.
29. Mazzotti M., Storti G., Morbidelli M. J. Chromatogr. A 1997, 769:3.
30. Storti G., Mazzotti M., Morbidelli M., Carra S. AIChE J. 1993, 39:471.
31. Keßler L.C., Seidel-Morgenstern A. J. Chromatogr. A 2006, 1126:323.
32. Azevedo D.C.S., Rodrigues A.E. AIChE J. 1999, 45:956.
33. Azevedo D.C.S., Rodrigues A.E. AIChE J. 2001, 47:2042.
34. Gong R.J., Lin X.J., Li P., Yu J.G., Rodrigues A.E. Chem. Eng. J. 2014, 244:128.
35. Lim Y.-I.I, Bhatia S.K. Adsorption 2011, 17:109.
36. Minceva M., Rodrigues A.E. Sep. Sci. Technol. 2003, 38:1463.