Design of SMB Chiral Separations Using the Concept of Separation Volume

Separation Science and Technology

Volumn 39, Issue 2, 2005, Pages 245-270

  Rodrigues, Alírio E ^a   Pais, Luís S ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b INSTITUTO POLITÉCNICO DE BRAGANÇA   (Portugal)

Author keywords

Chiral separation; Modeling; Numerical simulation; Separation volume; Simulated moving bed

Indexed keywords

ADSORPTION ISOTHERMS; CHROMATOGRAPHIC ANALYSIS; COMPUTER SIMULATION; MASS TRANSFER;

MASS TRANSFER RESISTANCE; SIMULATED MOVING BED (SMB) CHROMATOGRAPHY;

SEPARATION;

MATHEMATICAL ANALYSIS; MODELING; MOVING BED REGIME; SEPARATION;

ADSORPTION; CALCULATION; CHIRALITY; CHROMATOGRAPHY; ENANTIOMER; EVALUATION; FLOW RATE; MASS TRANSFER RESISTANCE; MATHEMATICAL MODEL; PARAMETER; REVIEW; SEPARATION TECHNIQUE; SIMULATED MOVING BED CHROMATOGRAPHY; SIMULATION; THEORY;

EID: 1542303716     PISSN: 01496395     EISSN: None     Source Type: Journal    
DOI: 10.1081/ss-120027557     Document Type: Review

References (40)

1. Anon. FDA's policy statement for the development of new stereoisomeric drugs. Chirality 1992, 4, 338.
2. Rekoske, J.E. Chiral separations. AIChE J. 2001, 47, 2.
3. Stinson, S.C. Chiral drugs. C&EN 1995, October 9, 44.
4. Broughton, D.B.; Gerhold, C.G. Continuous Sorption Process Employing Fixed Bed of Sorbent and Moving Inlets and Outlets. U.S. Patent No. 2,985,589, 1961.
5. Nicoud, R.M. The separation of optical isomers by simulated moving bed chromatography. Pharm. Tech. Europe 1999, 11 (3), 36.
6. Nicoud, R.M. The separation of optical isomers by simulated moving bed chromatography. Pharm. Tech. Europe 1999, 11 (4), 28.
7. McCoy, M. SMB emerges as chiral technique. C&EN 2000, June 19, 17.
8. Cox, G.B. Preparative enantioselective chromatography. In Current Status and Future Trends; PREPTECH-Preparative and Process Scale Technology in the Manufacturing of Chemicals and Pharmaceuticals: Mainz, Germany, April 18-20, 2001.
9. Stinson, S.C. Chiral chemistry. C&EN 2001, May 14, 45.
10. Nicoud, R.M. The simulated moving bed: a powerful chromatographic process. LC-GC Int. 1992, 5, 43.
11. Gattuso, M.J.; McCulloch, B.; House, D.W.; Baumann, W.M.; Gottschall, K. Simulated moving bed technology - the preparation of single enantiomer drugs. Pharm. Tech. Europe 1996, 8, 20.
12. Nicoud, R.M.; Majors, R.E. Simulated moving bed chromatography for preparative separations. LC-GC Europe 2000, 13, 887.
13. Blehaut, J.; Hauck, W.; Nicoud, R.M. Simulated moving bed (S.M.B.): principle and application to chiral separations. Seminar on Batch and SMB Design and Applications. AIChE Meeting, Chicago, March 2001.
14. Broughton, D.B. Production-scale adsorptive separations of liquid mixtures by simulated moving-bed technology. Sep. Sci. Technol. 1984, 19, 723.
15. Ruthven, D.M.; Ching, C.B. Counter-current and simulated counter-current adsorption separation processes. Chem. Engng Sci. 1989, 44, 1011.
16. Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. Separation of 1,1′-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed. Chem. Engng Sci. 1997, 52, 245.
17. Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. Modeling, strategies for enantiomers separation by SMB chromatography. AIChE J. 1998, 44, 561.
18. Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. Modeling separation and operation of a simulated moving bed for continuous chromatographic separation of 1,1′-bi-2-naphthol enantiomers. J. Chromatogr. A 1997, 769, 25.
19. Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. Separation of enantiomers of a chiral epoxide by simulated moving bed chromatography. J. Chromatogr. A 1998, 827, 215.
20. Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. Chiral separation by SMB chromatography. Sep. Purif. Technol. 2000, 20, 67.
21. Azevedo, D.C.S.; Pais, L.S.; Rodrigues, A.E. Enantiomers separation by simulated moving bed chromatography. Non-instantaneous equilibrium at the solid-fluid interface. J. Chromatogr. A 1999, 865, 187.
22. Azevedo, D.C.S.; Rodrigues, A.E. Design of a simulated moving bed in the presence of mass-transfer resistances. AIChE J. 1999, 45, 956.
23. Azevedo, D.C.S.; Rodrigues, A.E. Bilinear driving force approximation in the modeling of a simulated moving bed using bidisperse adsorbents. Ind. Eng. Chem. Res. 1999, 38, 3519.
24. Azevedo, D.C.S.; Rodrigues, A.E. Obtainment of high-fructose solutions from cashew (Anacardium occidentale) apple juice by simulated moving-bed chromatography. Sep. Sci. Technol. 2000, 35, 2561.
25. Rodrigues, A.E.; Pais, L.S. Modelling and simulation in SMB for chiral purification. In Chiral Separation Techniques. A Practical Approach - Second Completely Revised and Update Edition; Subramanian, G., Ed.; Wiley-VCH; 2000; 221.
26. Mazzotti, M.; Storti, G.; Morbidelli, M. Optimal operation of simulated moving bed units for nonlinear chromatographic separations. J. Chromatogr. A 1997, 769, 3.
27. Ma, Z.; Wang, N. Standing wave analysis of SMB chromatography: linear systems. AIChE J. 1997, 43, 2488.
28. Zhong, G.; Guiochon, G. Simulated moving bed chromatography. Effects of axial dispersion and mass transfer under linear conditions. Chem. Engng Sci. 1997, 52, 3117.
29. Yun, T.; Bensetiti, Z.; Zhong, G.; Guiochon, G. Effect of column efficiency on the internal concentration profiles and the performance of a simulated moving-bed unit in the case of a linear isotherm. J. Chromatogr. A 1997, 758, 175.
30. Xie, Y.; Wu, D.; Ma, Z.; Wang, N. Extended standing wave design method for simulated moving bed chromatography: linear systems. Ind. Eng. Chem. Res. 2000, 39, 1993.
31. Charton, F.; Nicoud, R.M. Complete design of a simulated moving bed. J. Chromatogr. A 1995, 702, 97.
32. Strube, J.; Altenhoner, U.; Meurer, M.; Schmidt-Traub, H.; Schulte, M. Dynamic simulation of simulated moving-bed chromatographic processes for the optimization of chiral separations. J. Chromatogr. A 1997, 769, 81.
33. Mallmann, T.; Burris, B.D.; Ma, Z.; Wang, N. Standing wave design of nonlinear SMB systems for fructose purification. AIChE J. 1998, 44, 2628.
34. Wu, D.J.; Xie, Y.; Ma, Z.; Wang, N. Design of simulated moving bed chromatography for amino acid separations. Ind. Eng. Chem. Res. 1998, 37, 4023.
35. Migliorini, C.; Gentilini, A.; Mazzotti, M.; Morbidelli, M. Design of simulated moving bed units under nonideal conditions. Ind. Eng. Chem. Res. 1999, 38, 2400.
36. Biressi, G.; Ludemann-Hombourger, O.; Mazzotti, M.; Nicoud, R.M.; Morbidelli, M. Design and optimisation of a simulated moving bed unit: role of deviations from equilibrium theory. J. Chromatogr. A 2000, 876, 3.
37. Ludemann-Hombourger, O.; Nicoud, R.M.; Bailly, M. The varicol process: a new multicolumn continuous chromatographic process. Sep. Sci. Technol. 2000, 35, 1829.
38. Bader, G.; Ascher, U. A new basis implementation for a mixed order boundary value ODE solver. SIAM J. Sci. Stat. Comput. 1987, 8, 483.
39. Ascher, U.; Christiansen, J.; Russell, R.D. A collocation solver for mixed order systems of boundary value problems. Math. Comput. 1979, 33, 659.
40. Ascher, U.; Christiansen, J.; Russell, R.D. Collocation software for boundary-value ODEs. ACM Trans. Math. Software 1981, 7, 209.