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Volumn 34, Issue 10, 2014, Pages 1473-1487

Soluble thrombomodulin attenuates sinusoidal obstruction syndrome in rat through suppression of high mobility group box 1

Author keywords

High mobility group box 1; Intracellular adhesion molecule 1; Neutrophil; Receptor for advanced glycation end products; Recombinant human soluble thrombomodulin; Sinusoidal obstruction syndrome

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; HYALURONIC ACID; INTERCELLULAR ADHESION MOLECULE 1; MONOCROTALINE; MYELOPEROXIDASE; RECOMBINANT THROMBOMODULIN; ANTINEOPLASTIC AGENT; HBP1 PROTEIN, RAT; RECOMBINANT PROTEIN; THROMBOMODULIN;

EID: 84908084367     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12420     Document Type: Article
Times cited : (29)

References (45)
  • 1
    • 34249988201 scopus 로고    scopus 로고
    • Liver resection for colorectal liver metastasis
    • Lochan R, White SA, Manas DM. Liver resection for colorectal liver metastasis. Surg Oncol 2007; 16: 33-45.
    • (2007) Surg Oncol , vol.16 , pp. 33-45
    • Lochan, R.1    White, S.A.2    Manas, D.M.3
  • 2
    • 0037409181 scopus 로고    scopus 로고
    • Veno-occlusive disease: cytokines, genetics, and haemostasis
    • Coppell JA, Brown SA, Perry DJ. Veno-occlusive disease: cytokines, genetics, and haemostasis. Blood Rev 2003; 17: 63-70.
    • (2003) Blood Rev , vol.17 , pp. 63-70
    • Coppell, J.A.1    Brown, S.A.2    Perry, D.J.3
  • 3
    • 11144354740 scopus 로고    scopus 로고
    • Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer
    • Rubbia-Brandt L, Audard V, Sartoretti P, et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Ann Oncol 2004; 15: 460-6.
    • (2004) Ann Oncol , vol.15 , pp. 460-466
    • Rubbia-Brandt, L.1    Audard, V.2    Sartoretti, P.3
  • 4
    • 37549068554 scopus 로고    scopus 로고
    • Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy
    • Nakano H, Oussoultzoglou E, Rosso E, et al. Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Ann Surg 2008; 247: 118-24.
    • (2008) Ann Surg , vol.247 , pp. 118-124
    • Nakano, H.1    Oussoultzoglou, E.2    Rosso, E.3
  • 5
    • 79951549930 scopus 로고    scopus 로고
    • Sinusoidal obstruction syndrome impairs long-term outcome of colorectal liver metastases treated with resection after neoadjuvant chemotherapy
    • Tamandl D, Klinger M, Eipeldauer S, et al. Sinusoidal obstruction syndrome impairs long-term outcome of colorectal liver metastases treated with resection after neoadjuvant chemotherapy. Ann Surg Oncol 2011; 18: 421-30.
    • (2011) Ann Surg Oncol , vol.18 , pp. 421-430
    • Tamandl, D.1    Klinger, M.2    Eipeldauer, S.3
  • 6
    • 0032696866 scopus 로고    scopus 로고
    • Recombinant thrombomodulin and activated protein C in the treatment of disseminated intravascular coagulation
    • Maruyama I. Recombinant thrombomodulin and activated protein C in the treatment of disseminated intravascular coagulation. Thromb Haemost 1999; 82: 718-21.
    • (1999) Thromb Haemost , vol.82 , pp. 718-721
    • Maruyama, I.1
  • 7
    • 33845513582 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial
    • Saito H, Maruyama I, Shimazaki S, et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost 2007; 5: 31-41.
    • (2007) J Thromb Haemost , vol.5 , pp. 31-41
    • Saito, H.1    Maruyama, I.2    Shimazaki, S.3
  • 8
    • 84858219292 scopus 로고    scopus 로고
    • Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors
    • Kashiwadate T, Miyagi S, Hara Y, et al. Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors. Transplant Proc 2012; 44: 369-72.
    • (2012) Transplant Proc , vol.44 , pp. 369-372
    • Kashiwadate, T.1    Miyagi, S.2    Hara, Y.3
  • 9
    • 0029819270 scopus 로고    scopus 로고
    • Recombinant thrombomodulin prevents endotoxin-induced lung injury in rats by inhibiting leukocyte activation
    • Uchiba M, Okajima K, Murakami K, et al. Recombinant thrombomodulin prevents endotoxin-induced lung injury in rats by inhibiting leukocyte activation. Am J Physiol 1996; 271: L470-5.
    • (1996) Am J Physiol , vol.271 , pp. L470-L475
    • Uchiba, M.1    Okajima, K.2    Murakami, K.3
  • 10
    • 44449114876 scopus 로고    scopus 로고
    • Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure
    • Ozaki T, Anas C, Maruyama S, et al. Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure. Nephrol Dial Transplant 2008; 23: 110-9.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 110-119
    • Ozaki, T.1    Anas, C.2    Maruyama, S.3
  • 11
    • 84865496914 scopus 로고    scopus 로고
    • Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling
    • Ikezoe T, Yang J, Nishioka C, et al. Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling. Arterioscler Thromb Vasc Biol 2012; 32: 2259-70.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2259-2270
    • Ikezoe, T.1    Yang, J.2    Nishioka, C.3
  • 13
    • 10844281923 scopus 로고    scopus 로고
    • Activation of human umbilical vein endothelial cells leads to relocation and release of high-mobility group box chromosomal protein 1
    • Mullins GE, Sunden-Cullberg J, Johansson AS, et al. Activation of human umbilical vein endothelial cells leads to relocation and release of high-mobility group box chromosomal protein 1. Scand J Immunol 2004; 60: 566-73.
    • (2004) Scand J Immunol , vol.60 , pp. 566-573
    • Mullins, G.E.1    Sunden-Cullberg, J.2    Johansson, A.S.3
  • 14
    • 20944436774 scopus 로고    scopus 로고
    • The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism
    • Abeyama K, Stern DM, Ito Y, et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest 2005; 115: 1267-74.
    • (2005) J Clin Invest , vol.115 , pp. 1267-1274
    • Abeyama, K.1    Stern, D.M.2    Ito, Y.3
  • 15
    • 67649535053 scopus 로고    scopus 로고
    • A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction
    • Narita M, Hatano E, Ikai I, et al. A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction. Ann Surg 2009; 249: 806-13.
    • (2009) Ann Surg , vol.249 , pp. 806-813
    • Narita, M.1    Hatano, E.2    Ikai, I.3
  • 16
    • 84867575484 scopus 로고    scopus 로고
    • Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9
    • Nakamura K, Hatano E, Narita M, et al. Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9. J Hepatol 2012; 57: 1037-43.
    • (2012) J Hepatol , vol.57 , pp. 1037-1043
    • Nakamura, K.1    Hatano, E.2    Narita, M.3
  • 17
    • 0033032746 scopus 로고    scopus 로고
    • Characterization of a reproducible rat model of hepatic veno-occlusive disease
    • DeLeve LD, McCuskey RS, Wang X, et al. Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology 1999; 29: 1779-91.
    • (1999) Hepatology , vol.29 , pp. 1779-1791
    • DeLeve, L.D.1    McCuskey, R.S.2    Wang, X.3
  • 18
    • 79251514644 scopus 로고    scopus 로고
    • Olprinone attenuates excessive shear stress through up-regulation of endothelial nitric oxide synthase in a rat excessive hepatectomy model
    • Yamanaka K, Hatano E, Narita M, et al. Olprinone attenuates excessive shear stress through up-regulation of endothelial nitric oxide synthase in a rat excessive hepatectomy model. Liver Transpl 2011; 17: 60-9.
    • (2011) Liver Transpl , vol.17 , pp. 60-69
    • Yamanaka, K.1    Hatano, E.2    Narita, M.3
  • 19
    • 65549132946 scopus 로고    scopus 로고
    • High mobility group box protein-1 in experimental autoimmune uveoretinitis
    • Watanabe T, Keino H, Sato Y, et al. High mobility group box protein-1 in experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 2009; 50: 2283-90.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2283-2290
    • Watanabe, T.1    Keino, H.2    Sato, Y.3
  • 20
    • 17644390629 scopus 로고    scopus 로고
    • Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia
    • Dorman RB, Gujral JS, Bajt ML, Farhood A, Jaeschke H. Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia. Am J Physiol Gastrointest Liver Physiol 2005; 288: G880-6.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288 , pp. G880-G886
    • Dorman, R.B.1    Gujral, J.S.2    Bajt, M.L.3    Farhood, A.4    Jaeschke, H.5
  • 21
  • 22
    • 79956210926 scopus 로고    scopus 로고
    • HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat
    • Liu A, Dirsch O, Fang H, et al. HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat. Histochem Cell Biol 2011; 135: 443-52.
    • (2011) Histochem Cell Biol , vol.135 , pp. 443-452
    • Liu, A.1    Dirsch, O.2    Fang, H.3
  • 24
    • 84872810012 scopus 로고    scopus 로고
    • Amelioration of compound 4,4′-diphenylmethane-bis(methyl)carbamate on high mobility group box1-mediated inflammation and oxidant stress responses in human umbilical vein endothelial cells via RAGE/ERK1/2/NF-κB pathway
    • Feng L, Zhu M, Zhang M, et al. Amelioration of compound 4, 4′-diphenylmethane-bis(methyl)carbamate on high mobility group box1-mediated inflammation and oxidant stress responses in human umbilical vein endothelial cells via RAGE/ERK1/2/NF-κB pathway. Int Immunopharmacol 2012; 15: 206-16.
    • (2012) Int Immunopharmacol , vol.15 , pp. 206-216
    • Feng, L.1    Zhu, M.2    Zhang, M.3
  • 25
    • 58149163610 scopus 로고    scopus 로고
    • Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease
    • Benimetskaya L, Wu S, Voskresenskiy AM, et al. Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease. Blood 2008; 112: 4343-52.
    • (2008) Blood , vol.112 , pp. 4343-4352
    • Benimetskaya, L.1    Wu, S.2    Voskresenskiy, A.M.3
  • 26
    • 41849095657 scopus 로고    scopus 로고
    • Early intervention with antithrombin III therapy to prevent progression of hepatic venoocclusive disease
    • Peres E, Kintzel P, Dansey R, et al. Early intervention with antithrombin III therapy to prevent progression of hepatic venoocclusive disease. Blood Coagul Fibrinolysis 2008; 19: 203-7.
    • (2008) Blood Coagul Fibrinolysis , vol.19 , pp. 203-207
    • Peres, E.1    Kintzel, P.2    Dansey, R.3
  • 27
    • 3042675010 scopus 로고    scopus 로고
    • Prevention of hepatic veno-occlusive disease by a combination of heparin and prostaglandin E1 in children undergoing hematopoietic stem cell transplantation
    • Inukai T, Sugita K, Goi K, et al. Prevention of hepatic veno-occlusive disease by a combination of heparin and prostaglandin E1 in children undergoing hematopoietic stem cell transplantation. Rinsho Ketsueki 2004; 45: 297-303.
    • (2004) Rinsho Ketsueki , vol.45 , pp. 297-303
    • Inukai, T.1    Sugita, K.2    Goi, K.3
  • 28
    • 0026720385 scopus 로고
    • Prevention of hepatic veno-occlusive disease after bone marrow transplantation by continuous infusion of low-dose heparin: a prospective, randomized trial
    • Attal M, Huguet F, Rubie H, et al. Prevention of hepatic veno-occlusive disease after bone marrow transplantation by continuous infusion of low-dose heparin: a prospective, randomized trial. Blood 1992; 79: 2834-40.
    • (1992) Blood , vol.79 , pp. 2834-2840
    • Attal, M.1    Huguet, F.2    Rubie, H.3
  • 29
    • 0034093330 scopus 로고    scopus 로고
    • The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno-occlusive disease after stem cell transplantation
    • Ohashi K, Tanabe J, Watanabe R, et al. The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno-occlusive disease after stem cell transplantation. Am J Hematol 2000; 64: 32-8.
    • (2000) Am J Hematol , vol.64 , pp. 32-38
    • Ohashi, K.1    Tanabe, J.2    Watanabe, R.3
  • 30
    • 0037908971 scopus 로고    scopus 로고
    • Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome
    • DeLeve LD, Ito Y, Bethea NW, et al. Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol 2003; 284: G1045-52.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284 , pp. G1045-G1052
    • DeLeve, L.D.1    Ito, Y.2    Bethea, N.W.3
  • 31
    • 0042825692 scopus 로고    scopus 로고
    • Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition
    • Deleve LD, Wang X, Tsai J, et al. Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology 2003; 125: 882-90.
    • (2003) Gastroenterology , vol.125 , pp. 882-890
    • Deleve, L.D.1    Wang, X.2    Tsai, J.3
  • 32
    • 77950624556 scopus 로고    scopus 로고
    • Successful treatment of sinusoidal obstructive syndrome after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin
    • Ikezoe T, Togitani K, Komatsu N, Isaka M, Yokoyama A. Successful treatment of sinusoidal obstructive syndrome after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin. Bone Marrow Transplant 2010; 45: 783-5.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 783-785
    • Ikezoe, T.1    Togitani, K.2    Komatsu, N.3    Isaka, M.4    Yokoyama, A.5
  • 33
    • 80052877711 scopus 로고    scopus 로고
    • Successful treatment with recombinant soluble thrombomodulin of two cases of sinusoidal obstructive syndrome/hepatic veno-occlusive disease after bone marrow transplantation
    • Ohwada C, Takeuchi M, Kawaguchi T, et al. Successful treatment with recombinant soluble thrombomodulin of two cases of sinusoidal obstructive syndrome/hepatic veno-occlusive disease after bone marrow transplantation. Am J Hematol 2011; 86: 886-8.
    • (2011) Am J Hematol , vol.86 , pp. 886-888
    • Ohwada, C.1    Takeuchi, M.2    Kawaguchi, T.3
  • 34
    • 84858082332 scopus 로고    scopus 로고
    • Recombinant human soluble thrombomodulin for the treatment of hepatic sinusoidal obstructive syndrome post allogeneic hematopoietic SCT
    • Nakamura D, Yoshimitsu M, Kawada H, et al. Recombinant human soluble thrombomodulin for the treatment of hepatic sinusoidal obstructive syndrome post allogeneic hematopoietic SCT. Bone Marrow Transplant 2012; 47: 463-4.
    • (2012) Bone Marrow Transplant , vol.47 , pp. 463-464
    • Nakamura, D.1    Yoshimitsu, M.2    Kawada, H.3
  • 35
    • 0031951276 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of a novel recombinant soluble human thrombomodulin, ART-123, in healthy male volunteers
    • Nakashima M, Kanamaru M, Umemura K, Tsuruta K. Pharmacokinetics and safety of a novel recombinant soluble human thrombomodulin, ART-123, in healthy male volunteers. J Clin Pharmacol 1998; 38: 40-4.
    • (1998) J Clin Pharmacol , vol.38 , pp. 40-44
    • Nakashima, M.1    Kanamaru, M.2    Umemura, K.3    Tsuruta, K.4
  • 36
    • 84888137538 scopus 로고    scopus 로고
    • Recombinant Human Thrombomodulin Suppresses Experimental Abdominal Aortic Aneurysms Induced by Calcium Chloride in Mice
    • Lai CH, Shi GY, Lee FT, et al. Recombinant Human Thrombomodulin Suppresses Experimental Abdominal Aortic Aneurysms Induced by Calcium Chloride in Mice. Ann Surg 2013; 258: 1103-10.
    • (2013) Ann Surg , vol.258 , pp. 1103-1110
    • Lai, C.H.1    Shi, G.Y.2    Lee, F.T.3
  • 37
    • 41049117932 scopus 로고    scopus 로고
    • Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)
    • van Beijnum JR, Buurman WA, Griffioen AW. Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1). Angiogenesis 2008; 11: 91-9.
    • (2008) Angiogenesis , vol.11 , pp. 91-99
    • van Beijnum, J.R.1    Buurman, W.A.2    Griffioen, A.W.3
  • 38
    • 84866162273 scopus 로고    scopus 로고
    • High mobility group box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathway
    • Ding HS, Yang J, Gong FL, et al. High mobility group box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathway. Gene 2012; 509: 143-53.
    • (2012) Gene , vol.509 , pp. 143-153
    • Ding, H.S.1    Yang, J.2    Gong, F.L.3
  • 39
    • 0030001831 scopus 로고    scopus 로고
    • Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells
    • Haraldsen G, Kvale D, Lien B, Farstad IN, Brandtzaeg P. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J Immunol 1996; 156: 2558-65.
    • (1996) J Immunol , vol.156 , pp. 2558-2565
    • Haraldsen, G.1    Kvale, D.2    Lien, B.3    Farstad, I.N.4    Brandtzaeg, P.5
  • 40
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H, Bloom O, Zhang M, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999; 285: 248-51.
    • (1999) Science , vol.285 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3
  • 41
    • 80051551176 scopus 로고    scopus 로고
    • Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice
    • Huang YH, Wang PW, Tiao MM, et al. Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice. J Surg Res 2011; 170: e47-55.
    • (2011) J Surg Res , vol.170 , pp. e47-e55
    • Huang, Y.H.1    Wang, P.W.2    Tiao, M.M.3
  • 42
    • 20244373939 scopus 로고    scopus 로고
    • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    • Tsung A, Sahai R, Tanaka H, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005; 201: 1135-43.
    • (2005) J Exp Med , vol.201 , pp. 1135-1143
    • Tsung, A.1    Sahai, R.2    Tanaka, H.3
  • 43
    • 84879605752 scopus 로고    scopus 로고
    • The ASC/Caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia-reperfusion injury
    • Kamo N, Ke B, Ghaffari AA, et al. The ASC/Caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia-reperfusion injury. Hepatology 2013; 58: 351-62.
    • (2013) Hepatology , vol.58 , pp. 351-362
    • Kamo, N.1    Ke, B.2    Ghaffari, A.A.3
  • 44
    • 84872162386 scopus 로고    scopus 로고
    • High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: interaction of γδ T cells with macrophages
    • Wang X, Sun R, Wei H, Tian Z. High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: interaction of γδ T cells with macrophages. Hepatology 2013; 57: 373-84.
    • (2013) Hepatology , vol.57 , pp. 373-384
    • Wang, X.1    Sun, R.2    Wei, H.3    Tian, Z.4
  • 45
    • 23844438376 scopus 로고    scopus 로고
    • Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement
    • Kearon C, Comp P, Douketis J, et al. Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement. J Thromb Haemost 2005; 3: 962-8.
    • (2005) J Thromb Haemost , vol.3 , pp. 962-968
    • Kearon, C.1    Comp, P.2    Douketis, J.3


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