Improvement of subcutaneous bioartificial pancreas vascularization and function by coencapsulation of pig islets and mesenchymal stem cells in primates

Cell Transplantation

Volumn 23, Issue 11, 2014, Pages 1349-1364

  Vériter, Sophie ^a   Gianello, Pierre ^a   Igarashi, Yasuhiro ^a   Beaurin, Gwen ^a   Ghyselinck, Audrey ^a   Aouassar, Najima ^b   Jordan, Bénédicte ^b   Gallez, Bernard ^b   Dufrane, Denis ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Bioartificial pancreas; Islets; Mesenchymal stem cells (MSCs); Oxygenation

Indexed keywords

GLYCOSYLATED HEMOGLOBIN;

ADIPOSE DERIVED STEM CELL; ADULT; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOARTIFICIAL ORGAN; BIOARTIFICIAL PANCREAS; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL ENCAPSULATION; CONTROLLED STUDY; DIABETES MELLITUS; EXPLANT; FEMALE; GRAFT RECIPIENT; IN VITRO STUDY; IN VIVO STUDY; LANDRACE PIG; LONG TERM SURVIVAL; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; OXYGENATION; PRIMATE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SUBCUTANEOUS TISSUE; VASCULARIZATION; ANIMAL; CELL ENGINEERING; CYTOLOGY; MACACA FASCICULARIS; MESENCHYMAL STROMA CELL; METABOLISM; PANCREAS; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PIG; PROCEDURES; RAT; WISTAR RAT; XENOGRAFT;

ANIMALS; BIOARTIFICIAL ORGANS; CELL ENGINEERING; FEMALE; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MACACA FASCICULARIS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; PANCREAS; RATS; RATS, WISTAR; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84908083681     PISSN: 09636897     EISSN: 15553892     Source Type: Journal    
DOI: 10.3727/096368913X663550     Document Type: Article

References (30)

1. Alejandro, R.; Barton, F. B.; Hering, B. J.; Wease, S. 2008 Update from the Collaborative Islet Transplant Registry. Transplantation 86:1783-1788; 2008.
2. Baudelet, C.; Gallez, B. Effect of anesthesia on the signal intensity in tumors using BOLD-MRI: Comparison with flow measurements by Laser Doppler flowmetry and oxygen measurements by luminescence-based probes. Magn. Reson. Imaging 22:905-912; 2004.
3. Carlsson, P. O.; Liss, P.; Andersson, A.; Jansson, L. Measurements of oxygen tension in native and transplanted rat pancreatic islets. Diabetes 47:1027-1032; 1998.
4. Carlsson, P. O.; Palm, F. Oxygen tension in isolated transplanted rat islets and in islets of rat whole-pancreas transplants. Transpl. Int. 15:581-585; 2002.
5. Diepart, C.; Verrax, J.; Calderon, P. B.; Feron, O.; Jordan, B. F.; Gallez, B. Comparison of methods for measuring oxygen consumption in tumor cells in vitro. Anal. Biochem. 396:250-256; 2010.
6. Dominici, M.; Le Blanc, K.; Mueller, I.; Slaper-Cortenbach, I.; Marini, F.; Krause, D.; Deans, R.; Keating, A.; Prockop, D.; Horwitz, E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315-317; 2006.
7. Dufrane, D.; Cornu, O.; Delloye, C.; Schneider, Y. J. Physical and chemical processing for a human dura mater substitute. Biomaterials 23:2979-2988; 2002.
8. Dufrane, D.; D’hoore, W.; Goebbels, R. M.; Saliez, A.; Guiot, Y.; Gianello, P. Parameters favouring successful adult pig islet isolations for xenotransplantation in pig-toprimate models. Xenotransplantation 13:204-214; 2006.
9. Dufrane, D.; Goebbels, R. M.; Gianello, P. Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression. Transplantation 90:1054-1062; 2010.
10. Dufrane, D.; Goebbels, R. M.; Saliez, A.; Guiot, Y.; Gianello, P. Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: Proof of concept. Transplantation 81:1345-1353; 2006.
11. Dufrane, D.; van Steenberghe, M.; Goebbels, R. M.; Saliez, A.; Guiot, Y.; Gianello, P. The influence of implantation site on the biocompatibility and survival of alginate 1363 encapsulated pig islets in rats. Biomaterials 27:3201-3208; 2006.
12. Dufrane, D.; van Steenberghe, M.; Guiot, Y.; Goebbels, R. M.; Saliez, A.; Gianello, P. Streptozotocin-induced diabetes in large animals (pigs/primates): Role of GLUT2 transporter and beta-cell plasticity. Transplantation 81:36-45; 2006.
13. Gallez, B.; Jordan, B. F.; Baudelet, C.; Misson, P. D. Pharmacological modifications of the partial pressure of oxygen in murine tumors: Evaluation using in vivo EPR oximetry. Magn. Reson. Med. 42:627-630; 1999.
14. Hirshberg, B.; Rother, K. I.; Digon, B. J., Lee, J.; Gaglia, J. L.; Hines, K.; Read, E. J.; Chang, R.; Wood, B. J.; Harlan, D. M. Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: The National Institutes of Health experience. Diabetes Care 26:3288-3295; 2003.
15. Jordan, B. F.; Peeterbroeck, J.; Karroum, O.; Diepart, C.; Magat, J.; Gregoire, V.; Gallez, B. Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms. Cancer Lett. 293:213-219; 2010.
16. Karaoz, E.; Genc, Z. S.; Demircan, P. C.; Aksoy, A.; Duruksu, G. Protection of rat pancreatic islet function and viability by coculture with rat bone marrow-derived mesenchymal stem cells. Cell Death. Dis. 1:e36; 2010.
17. Mineo, D.; Ricordi, C.; Xu, X.; Pileggi, A.; Garcia-Morales, R.; Khan, A.; Baidal, D. A.; Han, D.; Monroy, K.; Miller, J.; Pugliese, A.; Froud, T.; Inverardi, L.; Kenyon, N. S.; Alejandro, R. Combined islet and hematopoietic stem cell allotransplantation: A clinical pilot trial to induce chimerism and graft tolerance. Am. J. Transplant. 8:1262-1274; 2008.
18. Ohmura, Y.; Tanemura, M.; Kawaguchi, N.; Machida, T.; Tanida, T.; Deguchi, T.; Wada, H.; Kobayashi, S.; Marubashi, S.; Eguchi, H.; Takeda, Y.; Matsuura, N.; Ito, T.; Nagano, H.; Doki, Y.; Mori, M. Combined transplantation of pancreatic islets and adipose tissue-derived stem cells enhances the survival and insulin function of islet grafts in diabetic mice. Transplantation 90:1366-1373; 2010.
19. Poncelet, A. J.; Denis, D.; Gianello, P. Cellular xenotransplantation. Curr. Opin. Organ Transplant. 14:168-174; 2009.
20. Poncelet, A. J.; Vercruysse, J.; Saliez, A.; Gianello, P. Although pig allogeneic mesenchymal stem cells are not immunogenic in vitro, intracardiac injection elicits an immune response in vivo. Transplantation 83:783-790; 2007.
21. Rackham, C. L.; Chagastelles, P. C.; Nardi, N. B.; Hauge-Evans, A. C.; Jones, P. M.; King, A. J. Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice. Diabetologia 54:1127-1135; 2011.
22. Ryan, E. A.; Lakey, J. R.; Paty, B. W.; Imes, S.; Korbutt, G. S.; Kneteman, N. M.; Bigam, D.; Rajotte, R. V.; Shapiro, A. M. Successful islet transplantation: Continued insulin reserve provides long-term glycemic control. Diabetes 51:2148-2157; 2002.
23. Ryan, E. A.; Paty, B. W.; Senior, P. A.; Bigam, D.; Alfadhli, E.; Kneteman, N. M.; Lakey, J. R.; Shapiro, A. M. Fiveyear follow-up after clinical islet transplantation. Diabetes 54:2060-2069; 2005.
24. Schecroun, N.; Delloye, C. In vitro growth and osteoblastic differentiation of human bone marrow stromal cells supported by autologous plasma. Bone 35:517-524; 2004.
25. Schubert, T.; Xhema, D.; Veriter, S.; Schubert, M.; Behets, C.; Delloye, C.; Gianello, P.; Dufrane, D. The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells. Biomaterials 32: 8880-8891; 2011.
26. Schuleri, K. H.; Feigenbaum, G. S.; Centola, M.; Weiss, E. S.; Zimmet, J. M.; Turney, J.; Kellner, J.; Zviman, M. M.; Hatzistergos, K. E.; Detrick, B.; Conte, J. V.; McNiece, I.; Steenbergen, C.; Lardo, A. C.; Hare, J. M. Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy. Eur. Heart. J. 30:2722-2732; 2009.
27. Shapiro, A. M.; Lakey, J. R.; Ryan, E. A.; Korbutt, G. S.; Toth, E.; Warnock, G. L.; Kneteman, N. M.; Rajotte, R. V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343:230-238; 2000.
28. Shapiro, A. M.; Ricordi, C.; Hering, B. J.; Auchincloss, H.; Lindblad, R.; Robertson, R. P.; Secchi, A.; Brendel, M. D.; Berney, T.; Brennan, D. C.; Cagliero, E.; Alejandro, R.; Ryan, E. A.; DiMercurio, B.; Morel, P.; Polonsky, K. S.; Reems, J. A.; Bretzel, R. G.; Bertuzzi, F.; Froud, T.; Kandaswamy, R.; Sutherland, D. E.; Eisenbarth, G.; Segal, M.; Preiksaitis, J.; Korbutt, G. S.; Barton, F. B.; Viviano, L.; Seyfert-Margolis, V.; Bluestone, J.; Lakey, J. R. International trial of the Edmonton protocol for islet transplantation. N. Engl. J. Med. 355:1318-1330; 2006.
29. Veriter, S.; Aouassar, N.; Adnet, P. Y.; Paridaens, M. S.; Stuckman, C.; Jordan, B.; Karroum, O.; Gallez, B.; Gianello, P.; Dufrane, D. The impact of hyperglycemia and the presence of encapsulated islets on oxygenation within a bioartificial pancreas in the presence of mesenchymal stem cells in a diabetic Wistar rat model. Biomaterials 32:5945-5956; 2011.
30. Veriter, S.; Mergen, J.; Goebbels, R. M.; Aouassar, N.; Gregoire, C.; Jordan, B.; Leveque, P.; Gallez, B.; Gianello, P.; Dufrane, D. In vivo selection of biocompatible alginates for islet encapsulation and subcutaneous transplantation. Tissue Eng. Part A 16:1503-1513; 2010