The effect of naturally occurring chronic kidney disease on the micro-structural and mechanical properties of bone

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Shipov, Anna ^a   Segev, Gilad ^a   Meltzer, Hagar ^a   Milrad, Moran ^a   Brenner, Ori ^b   Atkins, Ayelet ^a   Shahar, Ron ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CREATININE; PARATHYROID HORMONE; PHOSPHORUS; VITAMIN D;

ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BODY WEIGHT; BONE DENSITY; BONE MASS; BONE MICROSTRUCTURE; BONE QUALITY; BONE STRENGTH; BONE STRESS; BONE STRUCTURE; CHRONIC KIDNEY DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; CORTICAL BONE; CORTICAL BONE ULTIMATE STRESS; CORTICAL BONE YIELD STRESS; CORTICAL CROSS SECTIONAL AREA; CORTICAL THICKNESS (BONE); CREATININE BLOOD LEVEL; DIAPHYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FEMUR; LUMBAR VERTEBRA; MALE; MORPHOMETRICS; MUSCULOSKELETAL SYSTEM PARAMETERS; NATURALLY OCCURRING CHRONIC KIDNEY DISEASE; NONHUMAN; OSTEOLYSIS; PHOSPHATE BLOOD LEVEL; POROSITY; PROSPECTIVE STUDY; TRABECULAR BONE; YOUNG MODULUS; ANIMAL; BONE; BONE DISEASES; CASE CONTROL STUDY; CAT; CHRONIC KIDNEY FAILURE; COMPLICATION; DISEASE MODEL; HUMAN; MECHANICS; METABOLISM; MICRO-COMPUTED TOMOGRAPHY; ORGAN SIZE; PATHOLOGY;

ANIMALS; BONE AND BONES; BONE DENSITY; BONE DISEASES; CASE-CONTROL STUDIES; CATS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MECHANICAL PHENOMENA; ORGAN SIZE; RENAL INSUFFICIENCY, CHRONIC; X-RAY MICROTOMOGRAPHY;

EID: 84908072560     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110057     Document Type: Article

References (47)

1. Lora CM, Daviglus ML, Kusek JW, Porter A, Ricardo AC, et al. (2009) Chronic kidney disease in United States Hispanics: a growing public health problem. Ethn Dis 19: 466-472.
2. McClellan WM, Plantinga LC (2013) A public health perspective on CKD and obesity. Nephrol Dial Transplant 28 Suppl 4: iv37-iv42.
3. Spasovski GB, Bervoets AR, Behets GJ, Ivanovski N, Sikole A, et al. (2003) Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis. Nephrol Dial Transplant 18: 1159-1166.
4. Levin A, Bakris GL, Molitch M, Smulders M, Tian J, et al. (2007) Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int 71: 31-38.
5. Cozzolino M, Ciceri P, Volpi EM, Olivi L, Messa PG (2009) Pathophysiology of calcium and phosphate metabolism impairment in chronic kidney disease. Blood Purif 27: 338-344.
6. Nabeshima Y (2008) The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis. Cell Mol Life Sci 65: 3218-3230.
7. Saito H, Kusano K, Kinosaki M, Ito H, Hirata M, et al. (2003) Human fibroblast growth factor-23 mutants suppress Na+ -dependent phosphate cotransport activity and 1 alpha,25-dihydroxyvitamin D-3 production. J Biol Chem 278: 2206-2211.
8. Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, et al. (2004) FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19: 429-435.
9. Ketteler M, Biggar PH, Liangos O (2013) FGF23 antagonism: the thin line between adaptation and maladaptation in chronic kidney disease. Nephrol Dial Transplant 28: 821-825.
10. Danese MD, Kim J, Doan QV, Dylan M, Griffiths R, et al. (2006) PTH and the risks for hip, vertebral, and pelvic fractures among patients on dialysis. Am J Kidney Dis 47: 149-156.
11. Alem AM, Sherrard DJ, Gillen DL, Weiss NS, Beresford SA, et al. (2000) Increased risk of hip fracture among patients with end-stage renal disease. Kidney Int 58: 396-399.
12. Coco M, Rush H (2000) Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone. Am J Kidney Dis 36: 1115-1121.
13. Stehman-Breen CO, Sherrard DJ, Alem AM, Gillen DL, Heckbert SR, et al. (2000) Risk factors for hip fracture among patients with end-stage renal disease. Kidney Int 58: 2200-2205.
14. Parfitt AM (1998) A structural approach to renal bone disease. J Bone Miner Res 13: 1213-1220.
15. Iwasaki Y, Kazama JJ, Yamato H, Shimoda H, Fukagawa M (2013) Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease. Bone 57: 477-483.
16. Bach-Gansmo FL, Irvine SC, Bruel A, Thomsen JS, Birkedal H (2013) Calcified Cartilage Islands in Rat Cortical Bone. Calcif Tissue Int 92: 330-338.
17. Shipov A, Zaslansky P, Riesemeier H, Segev G, Atkins A, et al. (2013) Unremodeled endochondral bone is a major architectural component of the cortical bone of the rat (Rattus norvegicus). J Struct Biol 183: 132-140.
18. Polzin DJ (2010) Chronic kidney disease. In: Ettinger SJ, Feldman EC, editors.Textbook of Veterinary Internal Medicine. 7th ed. St. Louis: Saunders. pp. 1990-2020.
19. Hillier ML, Bell LS (2007) Differentiating human bone from animal bone: A review of histological methods. J Forensic Sci 52: 249-263.
20. Segev G, Palm C, LeRoy B, Cowgill LD, Westropp JL (2013) Evaluation of neutrophil gelatinase-associated lipocalin as a marker of kidney injury in dogs. J Vet Intern Med 27: 1362-1367.
21. Zebaze RM, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, et al. (2010) Intracortical remodelling and porosity in the distal radius and postmortem femurs of women: a cross-sectional study. Lancet 375: 1729-1736.
22. Bousson V, Meunier A, Bergot C, Vicaut E, Rocha MA, et al. (2001) Distribution of intracortical porosity in human midfemoral cortex by age and gender. J Bone Miner Res 16: 1308-1317.
23. Montanari S, Brusatte SL, De Wolf W, Norell MA (2011) Variation of osteocyte lacunae size within the tetrapod skeleton: implications for palaeogenomics. Biol Lett 7: 751-754.
24. Urbanova P, Novotny V (2005) Distinguishing between human and non-human bones: Histometric method for forensic anthropology. Anthropologie 43: 77-85.
25. Currey JD, Shahar R (2013) Cavities in the compact bone in tetrapods and fish and their effect on mechanical properties. J Struct Biol 183: 107-122.
26. Kuchler U, Pfingstner G, Busenlechner D, Dobsak T, Reich K, et al. (2013) Osteocyte lacunar density and area in newly formed bone of the augmented sinus. Clin Oral Implants Res 24: 285-289.
27. Tazawa K, Hoshi K, Kawamoto S, Tanaka M, Ejiri S, et al. (2004) Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered. J Bone Miner Metab 22: 524-529.
28. Cohen L, Dean M, Shipov A, Atkins A, Monsonego-Ornan E, et al. (2012) Comparison of structural, architectural and mechanical aspects of cellular and acellular bone in two teleost fish. J Exp Biol 215: 1983-1993.
29. Sharir A, Barak MM, Shahar R (2008) Whole bone mechanics and mechanical testing. Vet J 177: 8-17.
30. Spatz HC, O'Leary EJ, Vincent JF (1996) Young's moduli and shear moduli in cortical bone. Proc Biol Sci 263: 287-294.
31. Draper ER, Goodship AE (2003) A novel technique for four-point bending of small bone samples with semi-automatic analysis. J Biomech 36: 1497-1502.
32. Turner CH, Burr DB (1993) Basic biomechanical measurements of bone: a tutorial. Bone 14: 595-608.
33. Miller MA, Chin J, Miller SC, Fox J (1998) Disparate effects of mild, moderate, and severe secondary hyperparathyroidism on cancellous and cortical bone in rats with chronic renal insufficiency. Bone 23: 257-266.
34. Cao HH, Nazarian A, Ackerman JL, Snyder BD, Rosenberg AE, et al. (2010) Quantitative P-31 NMR spectroscopy and H-1 MRI measurements of bone mineral and matrix density differentiate metabolic bone diseases in rat models. Bone 46: 1582-1590.
35. Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M (2011) Changes in chemical composition of cortical bone associated with bone fragility in rat model with chronic kidney disease. Bone 48: 1260-1267.
36. Jokihaara J, Jarvinen TLN, Jolma P, Koobi P, Kalliovalkama J, et al. (2006) Renal insufficiency-induced bone loss is associated with an increase in bone size and preservation of strength in rat proximal femur. Bone 39: 353-360.
37. Nickolas TL, Stein EM, Dworakowski E, Nishiyama KK, Komandah-Kosseh M, et al. (2013) Rapid cortical bone loss in patients with chronic kidney disease. J Bone Miner Res 28: 1811-1820.
38. Barou O, Valentin D, Vico L, Tirode C, Barbier A, et al. (2002) High-resolution three-dimensional micro-computed tomography detects bone loss and changes in trabecular architecture early: comparison with DEXA and bone histomorphometry in a rat model of disuse osteoporosis. Invest Radiol 37: 40-46.
39. Nickolas TL, Leonard MB, Shane E (2008) Chronic kidney disease and bone fracture: a growing concern. Kidney Int 74: 721-731.
40. Yenchek RH, Ix JH, Shlipak MG, Bauer DC, Rianon NJ, et al. (2012) Bone mineral density and fracture risk in older individuals with CKD. Clin J Am Soc Nephrol 7: 1130-1136.
41. Wasnich RD, Ross PD, Davis JW, Vogel JM (1989) A Comparison of Single and Multi-Site Bmc Measurements for Assessment of Spine Fracture Probability. J Nucl Med 30: 1166-1171.
42. Balon BP, Hojs R, Zavratnik A, Kos M (2002) Bone mineral density in patients beginning hemodialysis treatment. Am J Nephrol 22: 14-17.
43. Rix M, Andreassen H, Eskildsen P, Langdahl B, Olgaard K (1999) Bone mineral density and biochemical markers of bone turnover in patients with predialysis chronic renal failure. Kidney Int 56: 1084-1093.
44. Leonard MB (2009) A Structural Approach to Skeletal Fragility in Chronic Kidney Disease. Semin Nephrol 29: 133-143.
45. van Lenthe GH, Voide R, Boyd SK, Muller R (2008) Tissue modulus calculated from beam theory is biased by bone size and geometry: implications for the use of three-point bending tests to determine bone tissue modulus. Bone 43: 717-723.
46. Torcasio A, Van Oosterwyck H, van Lenthe GH (2008) The systematic errors in tissue modulus of murine bones when estimated from three-point bending. J Biomech 41: S14.
47. Nickolas TL, Stein E, Cohen A, Thomas V, Staron RB, et al. (2010) Bone mass and microarchitecture in CKD patients with fracture. J Am Soc Nephrol 21: 1371-1380.