An application of a Hill-based response surface model for a drug combination experiment on lung cancer

Statistics in Medicine

Volumn 33, Issue 24, 2014, Pages 4227-4236

  Ning, Shaoyang ^a   Xu, Hongquan ^b   Al Shyoukh, Ibrahim ^c,d   Feng, Jiaying ^c   Sun, Ren ^c  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Drug combination; Drug interaction; Factorial design; Hill model; Response surface model

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ADENOSINE TRIPHOSPHATE; INDIRUBIN; INDIRUBIN 3' MONOXIME; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; ANTINEOPLASTIC AGENT; INDIRUBIN-3'-MONOXIME; INDOLE DERIVATIVE; NITRILE; OXIME; TYRPHOSTIN;

A549 CELL LINE; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; DRUG EFFICACY; DRUG POTENTIATION; EXPERIMENTAL STUDY; FOLLOW UP; HUMAN; INTERMETHOD COMPARISON; LUNG CANCER; LUNG FIBROBLAST; RESPONSE SURFACE METHOD; STATISTICAL MODEL; SYSTEMATIC ERROR; VALIDATION PROCESS; DOSE RESPONSE; LUNG NEOPLASMS; METABOLISM; STATISTICAL ANALYSIS; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BUTADIENES; CELL LINE, TUMOR; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; LUNG NEOPLASMS; MODELS, STATISTICAL; NITRILES; OXIMES; TYRPHOSTINS;

EID: 84908069797     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.6229     Document Type: Article

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