Experimental design and interaction analysis of combination studies of drugs with log-linear dose responses

Statistics in Medicine

Volumn 27, Issue 16, 2008, Pages 3071-3083

  Fang, Hong Bin ^a,c   Ross, Douglas D ^a,b,c   Sausville, Edward ^a,c   Tan, Ming ^a,c  

^a UNIVERSITY OF MARYLAND   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Additive action; Dose effect; Experimental design; F test; Interaction index; Nonparametric model; Synergism; Uniform design

Indexed keywords

ETOPOSIDE; VORINOSTAT;

ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL STRAIN HL 60; DATA ANALYSIS; DOSE RESPONSE; DRUG POTENTIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOGLINEAR MODEL; MATHEMATICAL COMPUTING; NONHUMAN; NONPARAMETRIC TEST; POWER OF A TEST;

ANTINEOPLASTIC AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ETOPOSIDE; HUMANS; HYDROXAMIC ACIDS; MODELS, STATISTICAL; RESEARCH DESIGN; TUMOR CELLS, CULTURED;

EID: 48049096584     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.3204     Document Type: Article

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