Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats

Biochemical and Biophysical Research Communications

Volumn 434, Issue 2, 2013, Pages 203-209

  Arul, Duraikannu ^a   Subramanian, Perumal ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidants; Hepatocellular carcinoma; Lipid peroxidation; N Nitrosodiethylamine; Naringenin

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450; DIETHYLNITROSAMINE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE TRANSFERASE; NARINGENIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER INHIBITION; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER CELL CARCINOMA; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; BODY WEIGHT; CELL PROLIFERATION; DIETHYLNITROSAMINE; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; FLAVANONES; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OXIDATION-REDUCTION; PHYTOTHERAPY; RATS; RATS, WISTAR; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

CITRUS; RATTUS;

EID: 84877064248     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.039     Document Type: Article

References (45)

1. Jemal A., Siegel R., Ward E., Murray T., Xu J.Q., Thun M.J. Cancer statistics. CA Cancer J. Clin. 2007, 57:43-66.
2. Forner A., Llovet J.M., Bruix J. Hepatocellular carcinoma. Lancet 2012, 379:1245-1255.
3. Shire A.M., Roberts L.R. Prevention of hepatocellular carcinoma: progress and challenges. Minerva Gastroenterol. Dietol 2012, 58:49-64.
4. Venook A.P., Papandreou C., Furuse J., De Guevara L.L. The incidence and epidemiology of hepatocellular carcinoma: a gloabal and regional perspective. Oncologist 2010, 15:5-13.
5. Marrero J.A., Kudo M., Bronowicki J.P. The challenge of prognosis and staging for hepatocellular carcinoma. Oncologist 2010, 15:23-33.
6. Verna L., Whysner J., Williams G.M. N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol. Ther. 1996, 71:57-81.
7. Sivaramakrishnan V., Shilpa P.N., Praveen Kumar V.R., NiranjaliDevaraj S. Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin. Chem. Biol. Interact. 2008, 171:79-88.
8. Singh B.N., Braj Singh R., Sarma B.K., Singh H.B. Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem. Biol. Interact. 2009, 181:20-28.
9. Khan N., Afaq F., Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid. Redox Signaling 2008, 10:475-510.
10. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell. Biol. 2007, 39:44-84.
11. Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 2006, 160:1-40.
12. Kandaswami C., Middleton E. Free radical scavenging and antioxidant activity of plant flavonoids. Adv. Exp. Med. Biol. 1994, 366:351-376.
13. Russo M., Spagnuolo C., Tedesco I., Russo G.L. Phytochemicals in cancer prevention and therapy: truth or dare?. Toxins (Basel) 2010, 2:517-551.
14. Renugadevi J., Milton Prabu S. Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp. Toxicol. Pathol. 2010, 62:71-181.
15. Francis A.R., Shetty T.K., Bhattacharya R.K. Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N-nitro-N-nitrosoguanidine. Carcinogenesis 1988, 10:1953-1955.
16. Ekambaram G., Rajendran P., Magesh V., Sakthiskaran D. Naringenin reduces tumor size and weight lost in N-methyl-N-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Nutr. Res. 2008, 28:106-112.
17. Leonardi T., Vanamala J., Taddeo S.S., Davidson L.A., Murphy M.E., Patil B.S., Wang N., Caroll R.J., Chapkin R.S., Lupton J.R., Turner N.D. Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats. Exp. Biol. Med. (Maywood) 2010, 235:710-717.
18. Yoon H., Kim T.W., Shin S.Y., Park M.J., Yong Y., Kim D.W., Islam T., Lee Y.H., Jung K.Y., Lim Y. Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells. Bioorg. Med. Chem. Lett. 2013, 23:232-238.
19. P. Subramanian, D. Arul, Attenuation of NDEA-induced hepatocarcinogenesis by naringenin in rats, Cell Biochem. Funct., 2012. doi:10.1002/cbf.2929.
20. Ha W.S., Kim C.K., Sung S.H., Kang C.B. Study on the mechanism of multistep hepatotumorigenesis in rat: development of hepatotumorigenesis. J. Vet. Sci. 2001, 2:53-58.
21. Ramakrishnan G., Raghavendran H.R., Vinodhkumar R., Devaki T. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem. Biol. Interact. 2006, 161:104-114.
22. Omura T., Sato R. The carbon monoxide binding pigment of liver. J. Biol. Chem. 1964, 239:2370-2378.
23. Habig W.H., Pabst M.L., Jakpoly W.B. Glutathione transferase: a first enzymatic step in mercapturic acid and formation. J. Biol. Chem. 1974, 249:7130-7139.
24. Niehius W.G., Samuelson B. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid per-oxidation. Eur. J. Biochem. 1968, 6:26-130.
25. Jiang Z.Y., Hunt J.V., Wolff S.D. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal. Biochem. 1992, 202:384-389.
26. Kakkar P., Das B., Viswanathan P.N. A modified spectroscopic assay of superoxide dismustase. Indian J. Biochem. Biophys. 1984, 21:130-132.
27. Sinha A.K. Colorimetric assay of catalase. Anal. Biochem. 1972, 47:389-394.
28. Rotruck J.T., Pope A.L., Ganther H.E. Selenium: biochemical role as a component of glutathione peroxidase purification assay. Science 1973, 179:588-590.
29. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 2006, 82:70-77.
30. Omaye S.T., Turnbull J.D., Sauberlich H.E. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol. 1979, 62:1-11.
31. Desai I.D. Vitamin E analysis method for animal tissues. Methods Enzymol. 1984, 105:138-143.
32. Rosalki S.B., Rav D., Lchman D., Prentice M. Determination of serum gamma-glutamyltranspeptidase activity and its clinical applications. Ann. Clin. Biochem. 1970, 7:143-147.
33. Sell S., Beckar F.F. Alpha feto protein. Natl. Cancer Inst. 1978, 60:19-26.
34. Aiub C.A.F., Pinto L.F.R., Felzenszwalb I. N-Nitrosodiethylamine mutagenicity at low concentrations. Toxicol. Lett. 2003, 145:36-45.
35. Pegg A.E. Alkylating and subsequent repair of DNA after exposure to dimethylnitrosamine and related carcinogens. Rev. Biochem. Toxicol. 1983, 5:88-123.
36. Ganapathy E., Peramaiyan R., Rajasekaran D., Venkataraman M., Dhanapal S. Modulatory effect of naringenin on N-methyl-N'-nitro-N-nitrosoguanidine- and saturated sodium chloride-induced gastric carcinogenesis in male Wistar rats. Exp. Pharmacol. Physiol. 2008, 35:1190-1196.
37. Moon Y.J., Wang X., Morris M.E. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol. in Vitro 2006, 20:187-210.
38. Gey K.F. Prospects for the prevention of free radical disease, regarding cancer and cardiovascular disease. Br. Med. Bull. 1993, 49:679-699.
39. Banakar M.C., Paramasivan S.K., Chattopadhyay M.B., Datta S., Chakraborty P., Chatterjee M., Kannan K., Thyagarajan E. 1α,25-dihydroxyvitamin D3 prevents DNA damage restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine promoted by phenobarbital. World J. Gasteroenteral. 2004, 10:1268-1275.
40. Zwart L.L.D., Meerman J.N., Commandeur J.M. Biomarkers of free radical damage applications in experimental animals and humans. Free Radic. Biol. Med. 1999, 26:202-226.
41. Jeyabal P.V., Syed M.B., Venkataraman M. Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. Mol. Carcinog. 2005, 44:11-20.
42. Bulle F., Mavier P., Zafrani E.S., Preaux A.M., Lescs M.C., Siegrist S., Dhumeaux D., Guellaen G. Mechanism of γ-glutamyltranspeptidase release in serum during intrahepatic and extrahepatic cholestasis in the rat: a histochemical, biochemical and molecular approach. Hepatology 1990, 11:545-550.
43. Ramakrishnan G., Augustine T.A., Jagan S., Vinodhkumar R., Devaki T. Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Exp. Oncol. 2007, 29:39-44.
44. Taha M.M.E., Abdul A.B., Abdullah R., Ibrahim T.A.T., Abdelwahab S.I., Mohan S. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiberzerumbet). Chem. Biol. Interact. 2010, 186:295-305.
45. Lee M.H., Yoon S., Moon J.O. The flavonoid naringenin inhibits dimethylnitrosamine-induced liver damage in rats. Biol. Pharm. Bull. 2004, 27:72-76.