Tyrosinase-catalyzed oxidation of rhododendrol produces 2-methylchromane-6,7-dione, the putative ultimate toxic metabolite: Implications for melanocyte toxicity

Pigment Cell and Melanoma Research

Volumn 27, Issue 5, 2014, Pages 744-753

  Ito, Shosuke ^a   Ojika, Makoto ^b   Yamashita, Toshiharu ^c   Wakamatsu, Kazumasa ^a  

^a FUJITA HEALTH UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Melanocyte toxicity; Rhododendrol; Sulfhydryl group; Whitening agent: tyrosinase

Indexed keywords

2-METHYLCHROMANE-6,7-DIONE; BENZOPYRAN DERIVATIVE; BUTANOL; CATECHOL DERIVATIVE; DEPIGMENTING AGENT; FREE RADICAL; GLUTATHIONE; MONOPHENOL MONOOXYGENASE; OXYGEN; QUINONE DERIVATIVE; RHODODENDROL; SUPEROXIDE; WATER;

AGARICALES; CATALYSIS; CHEMISTRY; CYTOLOGY; CYTOSOL; DRUG EFFECTS; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MELANOCYTE; METABOLISM; ULTRAVIOLET SPECTROPHOTOMETRY;

AGARICALES; BENZOPYRANS; BUTANOLS; CATALYSIS; CATECHOLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOSOL; FREE RADICALS; GLUTATHIONE; HUMANS; MELANOCYTES; MONOPHENOL MONOOXYGENASE; OXYGEN; QUINONES; SKIN LIGHTENING PREPARATIONS; SPECTROPHOTOMETRY, ULTRAVIOLET; SUPEROXIDES; WATER;

EID: 84908012884     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/pcmr.12275     Document Type: Article

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