A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmenting agent monobenzone: Self-coupling and thiol-conjugation reactions and possible implications for melanocyte toxicity

Chemical Research in Toxicology

Volumn 22, Issue 8, 2009, Pages 1398-1405

  Manini, Paola ^a   Napolitano, Alessandra ^a   Westerhof, Wiete ^b   Riley, Patrick A ^c   D'Ischia, Marco ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Color Foundation ^*  (Netherlands)

^c Totteridge Institute for Advanced Studies   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BIPHENYL; BOVINE SERUM ALBUMIN; CATECHOL DERIVATIVE; CYSTEINE; GLUTATHIONE; LEVODOPA; MONOBENZONE; MONOPHENOL MONOOXYGENASE; QUINONE DERIVATIVE; THIOL DERIVATIVE;

ACETYLATION; AMINO ACID SYNTHESIS; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ISOLATION PROCEDURE; MELANOCYTE; OXIDATION; OXIDATION KINETICS; REACTION ANALYSIS; REDUCTION;

ANIMALS; CATECHOL OXIDASE; CATTLE; GLUTATHIONE; MELANOCYTES; MONOPHENOL MONOOXYGENASE; QUINONES;

BASIDIOMYCOTA; BOVINAE;

EID: 68949127025     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx900018q     Document Type: Article

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