Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: Possible mechanisms of neuroprotection

Epilepsy and Behavior

Volumn 41, Issue , 2014, Pages 98-102

  Golechha, Mahaveer ^a,b   Sarangal, Vikas ^a   Bhatia, Jagriti ^a   Chaudhry, Uma ^c   Saluja, Daman ^c   Arya, Dharmveer Singh ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b PUBLIC HEALTH FOUNDATION OF INDIA   (India)

^c UNIVERSITY OF DELHI   (India)

Author keywords

Cognitive impairment; Flumazenil; GABAergic; Naringin; PTZ; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AURANTIIN; DIAZEPAM; FLUMAZENIL; GLUTATHIONE; MALONALDEHYDE; PENTETRAZOLE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; CONVULSANT AGENT; FLAVANONE DERIVATIVE; NEUROPROTECTIVE AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; INFLAMMATION; MALE; MYOCLONUS SEIZURE; NEUROPHARMACOLOGY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE TEST; PENTYLENETETRAZOLE-INDUCED SEIZURE; RAT; TONIC CLONIC SEIZURE; TREATMENT DURATION; TREATMENT RESPONSE; ANIMAL; CHEMICALLY INDUCED; COGNITION DISORDERS; DRUG EFFECTS; SEIZURES;

ANIMALS; COGNITION DISORDERS; CONVULSANTS; FLAVANONES; INFLAMMATION; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PENTYLENETETRAZOLE; RATS; SEIZURES;

EID: 84908006711     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2014.09.058     Document Type: Article

References (35)

1. Savic I. Sex differences in human epilepsy. Exp Neurol 2014, 259C:38-43.
2. Beghi E., Schmidt D. When and how to stop antiepileptic drugs. Epileptology 2013, 1(1):17-20.
3. Ding J., Wang J.J., Huang C., Wang L., Deng S., Xu T.L., et al. Curcumol from Rhizoma Curcumae suppresses epileptic seizure by facilitation of GABA(A) receptors. Neuropharmacology 2014, 81:244-255.
4. Wallace M.L., Burette A.C., Weinberg R.J., Philpot B.D. Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects. Neuron 2012, 74(5):793-800.
5. Kołosowska K., Maciejak P., Szyndler J., Turzyńska D., Sobolewska A., Płaźnik A. The role of interleukin-1β in the pentylenetetrazole-induced kindling of seizures, in the rat hippocampus. Eur J Pharmacol 2014, 731:31-37.
6. Aniol V.A., Ivanova-Dyatlova A.Y., Keren O., Guekht A.B., Sarne Y., Gulyaeva N.V. A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. Epilepsy Behav 2013, 26(2):196-202.
7. Erdoğan F., Gölgeli A., Arman F., Ersoy A.Ö. The effects of pentylenetetrazole-induced status epilepticus on behavior, emotional memory, and learning in rats. Epilepsy Behav 2004, 5(3):388-393.
8. Waldbaum S., Patel M. Mitochondria, oxidative stress, and temporal lobe epilepsy. Epilepsy Res 2010, 88(1):23-45.
9. Vezzani A., Granata T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005, 46(11):1724-1743.
10. Ravizza T., Balosso S., Vezzani A. Inflammation and prevention of epileptogenesis. Neurosci Lett 2011, 497(3):223-230.
11. Auvin S., Mazarati A., Shin D., Sankar R. Inflammation enhances epileptogenesis in the developing rat brain. Neurobiol Dis 2010, 40(1):303-310.
12. Rajadurai M., Prince P.S. Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. Phytother Res 2009, 23(3):358-362.
13. Cavia-Saiz M., Busto M.D., Pilar-Izquierdo M.C., Ortega N., Perez-Mateos M., Muñiz P. Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study. J Sci Food Agric 2010, 90(7):1238-1244.
14. Jeon S.M., Bok S.H., Jang M.K., Lee M.K., Nam K.T., Park Y.B., et al. Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci 2001, 69(24):2855-2866.
15. Zbarsky V., Datla K.P., Parkar S., Rai D.K., Aruoma O.I., Dexter D.T. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res 2005, 39(10):1119-1125.
16. Kumar A., Prakash A., Dogra S. Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by d-galactose in mice. Food Chem Toxicol 2010, 48(2):626-632.
17. Golechha M., Chaudhry U., Bhatia J., Saluja D., Arya D.S. Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biol Pharm Bull 2011, 34(3):360-365.
18. Golechha M., Bhatia J., Arya D.S. Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats. Indian J Exp Biol 2010, 48(5):474-478.
19. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95(2):351-358.
20. Gl Ellman Tissue sulfhydryl groups. Arch Biochem Biophys 1959, 82(1):70-77.
21. Rubio C., Rubio-Osornio M., Retana-Márquez S., Verónica Custodio M.L., Paz C. In vivo experimental models of epilepsy. Cent Nerv Syst Agents Med Chem 2010, 10(4):298-309.
22. Hunsberger J.G., Bennett A.H., Selvanayagam E., Duman R.S., Newton S.S. Gene profiling the response to kainic acid induced seizures. Brain Res Mol Brain Res 2005, 141(1):95-112.
23. De Deyn P.P., D'Hooge R., Marescau B., Pei Y.-Q. Chemical models of epilepsy with some reference to their applicability in the development of anticonvulsants. Epilepsy Res 1992, 12(2):87-110.
24. Ilhan A., Gurel A., Armutcu F., Kamisli S., Iraz M. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacology 2005, 49(4):456-464.
25. González-Ramírez M., Razo-Juárez L.I., Sauer-Ramírez J.L., González-Trujano M.E., Salgado-Ceballos H., Orozco-Suarez S. Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats. Pharmacol Biochem Behav 2010, 97(2):267-272.
26. Chauhan A.K., Dobhal M.P., Joshi B.C. A review of medicinal plants showing anticonvulsant activity. J Ethnopharmacol 1988, 22(1):11-23.
27. Bough K.J., Matthews P.J., Eagles D.A. A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion. Epilepsy Res 2000, 38(2-3):105-114.
28. Akbas S.H., Yegin A., Ozben T. Effect of pentylenetetrazol-induced epileptic seizure on the antioxidant enzyme activities, glutathione and lipid peroxidation levels in rat erythrocytes and liver tissues. Clin Biochem 2005, 38(11):1009-1014.
29. Sahu B.D., Tatireddy S., Koneru M., Borkar R.M., Kumar J.M., Kuncha M., et al. Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection. Toxicol Appl Pharmacol 2014, 277(1):8-20.
30. Vezzani A., Moneta D., Richichi C., Perego C., De Simoni M.G. Functional role of proinflammatory and anti-inflammatory cytokines in seizures. Adv Exp Med Biol 2004, 548:123-133.
31. Bharti S., Rani N., Krishnamurthy B., Arya D.S. Preclinical evidence for the pharmacological actions of naringin: a review. Planta Med 2014, 80(6):437-451.
32. Liu Y., Wu H., Nie Y.C., Chen J.L., Su W.W., Li P.B. Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. Int Immunopharmacol 2011, 11(10):1606-1612.
33. A receptor function in health and disease. Biochem Soc Trans 2009, 37(Pt 6):1317-1322.
34. Gale K. Role of GABA in the genesis of chemoconvulsant seizures. Toxicol Lett 1992, 64-65:417-428.
35. Mortazavi F., Ericson M., Story D., Hulce V.D., Dunbar G.L. Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats. Epilepsy Behav 2005, 7(4):629-638.