Comparative study on the protective role of vitamin C and L-arginine in experimental renal ischemia reperfusion in adult rats

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 6, Issue 3, 2014, Pages 153-165

  Mohamed, Abd El Hamid A ^a   Lasheen, Noha N ^a  

^a AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

L arginine; Oxidative stress; Renal ischemia reperfusion; Vitamin C

Indexed keywords

ARGININE; ASCORBIC ACID; CATALASE; CREATININE; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; UREA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL INFILTRATION; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; EPITHELIUM CELL; HISTOPATHOLOGY; KIDNEY ISCHEMIA; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION; REPERFUSION INJURY; SINGLE DRUG DOSE; UREA BLOOD LEVEL;

EID: 84908005289     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. Star RA. Treatment of acute renal failure. Kidney Int 1998; 54: 1817-1831.
2. Ko GJ, Boo C, Jo S, Cho WY and Kim HK. Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury. Nephrol Dial Transplant 2008; 23: 842-852.
3. Basile DP. The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function. Kidney Int 2007; 72: 151-156.
4. Kim J, Jang H and Park KM. Reactive oxygen species generated by renal ischemia and reperfusion trigger protection against subsequent renal ischemia and reperfusion injury in mice. Am J Physiol Renal Physiol 2010; 298: F158-F166.
5. Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P and Bidani AK. Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 2010; 298: F1078-F1094.
6. Basile DP, Leonard EC, Tonade D, Friedrich J., Goenka S. Distinct effects on long-term function of injured and contralateral kidneys following unilateral renal ischemia-reperfusion. Am J Physiol Renal Physiol 2012; 302: F625-F635.
7. Basile DP, Leonard EC, Beal AG, Schleuter D and Friedrich J. Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity. Am J Physiol Renal Physiol 2012; 302: F1494-F1502.
8. Nath K and Norby S. Reactive oxygen species and acute renal failure. Am J Med 2000; 109: 665-678.
9. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002; 82: 47-95.
10. Nordberg J and Arner ES. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Me 2001; 31: 1287-1312.
11. Dobashi K, Ghosh B, Orak JK, Singh I, Singh AK. Kidney ischemia-reperfusion: Modulation of antioxidant defenses. Mol Cell Biochem 2000; 205: 1-11.
12. Padanilam BJ. Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol 2003; 284: F608-F627.
13. Spargias K, Alexopoulos E, Kyrzopoulos S, Iokovis P, Greenwood DC, Manginas A, Voudris V, Pavlides G, Buller CE. Kremastinos D and Cokkinos DV. Ascorbic acid prevents contrast-mediated nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. Circulation 2004; 110: 2837-2842.
14. Kim J, Kil IS, Seok YM, Yang ES, Kim DK, Lim DG, Park JW, Bonventre JV and Park KM. Orchiectomy attenuates post-ischemic oxidative stress and ischemia/reperfusion injury in mice. A role for manganese superoxide dismutase. J Biol Chem 2006; 281: 20349-20356.
15. Niki E. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. Am J Clin Nutr 1991; 54: 1119S-1124S.
16. Antunes LM, Darin JD and Bianchi MD. Protective effects of vitamin C against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study. Pharmacol Res 2000; 41: 405-411.
17. Ocak S, Gorur S, Hakverdi S, Celik S and Erdogan S. Protective effects of caffeic acid phe-nethyl ester, vitamin C, vitamin E and N-acetylcysteine on vancomycin-induced nephrotoxicity in rats. Basic Clin Pharmacol Toxicol 2007; 100: 328-333.
18. Kone BC and Baylis C. Biosynthesis and homeostatic roles of nitric oxide in the normal kidney. Am J Physiol 1997; 272: F561-F578.
19. Majid DSA and Navar LG. nitric oxide in the control of renal hemodynamics and excretory function. Am J Hypertens 2001; 14: 74S-82S.
20. Ashab I, Peer G, Blum M, Wollman Y, Chernihovsky T, Hassner A, Schwartz D, Cabili S, Silverberg D and Iaina A. Oral administration of L-arginine and captopril in rats prevents chronic renal failure by Nitric oxide production. Kidney Int 1995; 47: 1515-1521.
21. Caramelo C, Espinosa G, Manzarbeitia F, Cernadas MR, Pérez Tejerizo G, Tan D, Mosquera JR, Digiuni E, Montón M, Millás I, Hernando L, Casado S, López-Farré A. Role of endotheliumrelated mechanisms in the pathophysiology of renal ischemia/reperfusion in normal rabbits. Circ Res 1996; 79: 1031-1038.
22. Schwartz D, Mendonca M, Schwartz I, Xia Y, Satriano J, Wilson CB and Blantz RC. Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. J Clin Investig 1997; 100: 439-448.
23. Gabbai FB and Blantz RC. Role of nitric oxide in renal hemodynamics. Semin Nephrol 1999; 19: 242-250.
24. Rhoden EL, Rhoden CR, Lucas ML, Pereira-Lima L, Zettler C and Belló-Klein A. The role of nitric oxide pathway in the renal ischemia–reperfusion injury in rats. Transplant Immunology 2002; 10: 277-284.
25. Chatterjee PK, Patel NS, Kvale EO, Cuzzocrea S, Brown PA, Stewart KN, Mota-Filipe H, Thiemermann C. Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney Int 2002; 61: 862-871.
26. Walker LM, Walker PD, Imam SZ, Ali SF and Mayeux PR. Evidence for peroxynitrite formation in renal ischemia–reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N (6)-(1-Iminoethyl) lysine. J Pharmacol Exp Ther 2000; 295: 417-422.
27. Goligorsky MS and Noiri E. Duality of nitric oxide in acute renal failure. Semin Nephrol 1999; 19: 263-271.
28. Conger JD, Robinette JB and Hammond WS. Differences in vascular reactivity in models of ischemic acute renal failure. Kidney Int 1991; 39: 1087-1097.
29. Chintala MS, Chiu PJS, Vemulapalli S, Watkins RW and Sybertz EJ. Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats. Naunyn-Schmiedeberg’s Arch Pharmacol 1993; 348: 305-310.
30. Pryor WA and Squadrito GL. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 1995; 268: L699-L722.
31. Conger JD, Robinette JB and Schrier RW. Smooth muscle calcium and endothelium-derived relaxing factor in the abnormal vascular responses of acute renal failure. J Clin Investig 1988; 82: 532-537.
32. Schramm L, Heidbreder E, Schmitt A, Kartenbender K, Zimmermann J, Ling H and Heidland A. Role of L-arginine-derived NO in ischemic acute renal failure in the rat. Renal Failure 1994; 16: 555-569.
33. Kelly KJ. Distant Effects of Experimental Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol 2003; 14: 1549-1558.
34. Acquaviva R, Lanteri R, Li Destri G, Caltabiano R, Vanella L, Lanzafame S, Di Cataldo A, Li Volti G and Di Giacomo C. Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2009; 296: G664-G670.
35. Kanter M, Coskun O, Armutcu F, Uz YH and Kizilay G. Protective Effects of Vitamin C, Alone or in Combination with Vitamin A, on Endotoxin-Induced Oxidative Renal Tissue Damage in Rats. Tohoku J Exp Med 2005; 206: 155-162.
36. Searcy RL, Reardon JE and Foreman JA. A new photometric method for serum urea nitrogen determination. Am J Med Technol 1967; 33: 15-20.
37. Fabiny DL and Ertingshausen G. Automated Reaction-Rate Method for determination of serum creatinine with the centrifichem. Clinical Chem 1971; 17: 696-700.
38. Labbé D, Vassault A, Cherruau B, Baltassat P, Bonète R, Carroger G, Costantini A, Guérin S, Houot O, Lacour B, Nicolas A, Thioulouse E and Trépo D. Method selected for the determination of creatinine in plasma or serum. Choice of optimal conditions of measurement. Ann Biol Clin (Paris) 1996; 54: 285-298.
39. Eissa S, Khalifa A and El-Ahmady O. Tumor markers in malignant and benign breast tissue CA15.3, CEA and ferritin in cytosol and membrane enriched fractions. J Tumor Marker Oncol 1990; 5: 220.
40. Esterbauer H and Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990; 186: 407-421.
41. Bories PN and Bories C. Nitrate determination in biological fluids by an enzymatic one-step assay with nitrate reductase. Clinical Chemistry 1995; 41: 904-907.
42. Aebi H. Catalase in vitro. Methods Enzymol 1984; 105: 121-126.
43. Nishikimi M, Appaji N and Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Comm 1972; 46: 849.
44. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM and Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia–reperfusion injury. Cardiovasc Res 2005; 67: 594-603.
45. Bonventre JV and Zuk A. Ischemic acute renal failure: an inflammatory disease? Kidney Int 2004; 66: 480-485.
46. Ysebaert DK, De Greef KE, De Beuf A, Van Rompay AR, Vercauteren S, Persy VP and De Broe ME. T cells as mediators in renal ischemia/reperfusion injury. Kidney Int 2004; 66: 491-496.
47. Fekete A, Vannay A, Ver A, Vasarhelyi B, Muller V, Ouyang N, Reusz G, Tulassay T and Szabo AJ. Sex differences in the alterations of Na(+), K(+)-ATPase following ischaemia–reperfusion injury in the rat kidney. J Physiol 2004; 555: 471-480.
48. Singh D, Chander V and Chopra K. Protective effect of catechin on ischemia-reperfusion-induced renal injury in rats. Pharmacol Rep 2005; 57: 70-76.
49. Rasoulian B, Jafari M, Noroozzadeh A, Mehrani H, Wahhab-Aghai H, Hashemi-Madani SMH, Ghani E, Esmaili M, Asgar A and Khoshbaten A. Effects of ischemia-reperfusion on rat renal tissue antioxidant systems and lipid peroxidation. Acta Medica Iranica 2008; 46: 353-360.
50. Yamasowa H, Shimizu S, Inoue T, Takaoka M and Matsumura Y. Endothelial Nitric 0xide Contributes to the Renal Protective Effects of Ischemic Preconditioning. JPET 2005; 312: 153-159.
51. Korkmaz A and Kolankaya D. The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats. Renal Failure 2009; 31: 36-43.
52. Vinodini NA, Tripathi Y, Raghuveer CV, Ranade A, Kamath A and Pai S. Effect of antioxidants (vitamin C) on tissue ceruloplasmin following renal ischemia reperfusion in Wistar rats. International Journal of Biomedical and Advance Research 2012; 3: 36-39.
53. Patel KD, Zimmerman GA, Prescott SM, McEver RP and McIntyre TM. Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J Cell Biol 1991; 112: 749-759.
54. Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J 1991; 277: 133-138.
55. Lehr HA, Frei B and Afors KE. Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo. Proc Natl Acad Sci U S A 1994; 91: 7688-7692.
56. Lloberas N, Torras J, Herrero-Fresneda I, Cruzado JM, Riera M, Hurtado I and Griny JM. Postischemic renal oxidative stress induces inflammatory response through PAF and oxidized phospholipids. Prevention by antioxidant treatment. FASEB J 2002; 16: 908-910.
57. Garcia-Criado FJ, Eleno N, Santos-Benito F, Valdunciel JJ, Reverte M, Lozano-Sánchez FS, Ludeña MD, Gomez-Alonso A and López-Novoa JM. Protective effect of exogenous Nitric Oxide on the renal function and inflammatory response in a model of ischemia-reperfusion.Transplantation 1998; 66: 982-990.
58. Nakajima A, Ueda K, Takaoka M, Yoshimi Y and Matsumura Y. Opposite Effects of Pre- and Postischemic Treatments with Nitric Oxide Donor on Ischemia/Reperfusion-Induced Renal Injury. J Pharmacol Exp Ther 2006; 316: 1038-1046.
59. Tripatara P, Patel NSA, Webb A, Rathod K, Lecomte FMJ, Mazzon E, Cuzzocrea S, Yaqoob MM, Ahluwalia A and Thiemermann C. Nitrite-Derived Nitric Oxide Protects the Rat Kidney against Ischemia/Reperfusion Injury In Vivo: Role for Xanthine Oxidoreductase. J Am Soc Nephrol 2007; 18: 570-580.
60. Rhee JE, Jung SE, Shin SD, Suh GJ, Noh DY, Youn YK, Oh SK and Choe KJ. The effects of antioxidants and nitric oxide modulators on hepatic ischemic-reperfusion injury in rats. J Korean Med Sci 2002; 17: 502-506.
61. Rusai K, Fekete A, Szebeni B, Vannay A, Bokodi G, Müller V, Viklicky O, Bloudickova S, Rajnoch J, Heemann U, Reusz G, Szabó A, Tulassay T and Szabó AJ. Effect of inhibition of neuronal nitric oxide synthase and L-arginine supplementation on renal ischemia-reperfusion injury and the renal nitric oxide system. Clin Exp Pharmacol Physiol 2008; 35: 1183-1189.
62. Goligorsky MS, Brodsky SV and Noiri E. Nitric oxide in acute renal failure: NOS versus NOS. Kidney Int 2002; 61: 855-861.
63. Noiri E, Peresieni T, Miller F and Goligorsky MS. In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J Clin Invest 1996; 97: 2377-2383.
64. Arellano-Mendoza MG, Vargas-Robles H, Del Valle-Mondragon L, Rios A and Escalante B. Prevention of renal injury and endothelial dysfunction by chronic L-Arginine and antioxidant treatment. Ren Fail 2011; 33: 47-53.
65. Miloradović Z, Mihailović-Stanojević N, Grujić-Milanović J, Ivanov M, Kuburović G, Marković-Lipkovski J and Jovović D. Comparative effects of L-arginine and vitamin C pretreatment in SHR with induced postischemic acute renal failure. Gen Physiol Biophys 2009; 28: 105-111.
66. Unal D, Yeni E, Erel O, Bitiren M and Vural H. Antioxidative effects of exogenous nitric oxide versus antioxidant vitamins on renal ischemia reperfusion injury. Urol Res 2002; 30: 190-194.
67. Mahfoudh-Boussaid A, Badet L, Zaouali A, Saidane-Mosbahi D, Miled A and Ben Abdennebi H. Effect of ischaemic preconditioning and vitamin C on functional recovery of ischaemic kidneys. Prog Urol 2007; 17: 836-840.
68. Chander V and Chopra K. Protective effect of nitric oxide pathway in resveratrol renal ischemia- reperfusion injury in rats. Arch Med Res 2006; 37: 19-26.
69. Erdogan H, Fadillioglu E, Yagmurca M, Uçar M and Irmak MK. Protein oxidation and lipid peroxidation after renal ischemia-reperfusion injury: protective effects of erdosteine and N-acetylcysteine. Urol Res 2006; 34: 41-46.
70. Gonzalez-Flecha B, Evelson P, Sterin-Speziale N and Boveris A. Hydrogen peroxide metabolism and oxidative stress in cortical, medullary and papillary zones of rat kidney. Biochim Biophys Acta 1993; 1157: 155-161.