Mechanistic studies of a novel mycophenolic acid-glucosamine conjugate that attenuates renal ischemia/reperfusion injury in rat

Molecular Pharmaceutics

Volumn 11, Issue 10, 2014, Pages 3503-3514

  Wang, Xiaohong ^a   Xiong, Menghua ^a   Zeng, Yingchun ^a   Sun, Xun ^a   Gong, Tao ^a   Zhang, Zhirong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

inflammation; ischemia reperfusion; mycophenolic acid glucosamine conjugate; renal targeting

Indexed keywords

COMPLEMENT COMPONENT C3; FREE RADICAL; GLUCOSAMINE; INOSINE 5 MONOPHOSPHATE DEHYDROGENASE 2; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; KIDNEY INJURY MOLECULE 1; MALONALDEHYDE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID GLUCOSAMINE CONJUGATE; OSTEOGENIC PROTEIN 1; OXIDOREDUCTASE; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; INOSINATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL ADHESION; CELL INFILTRATION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; DRUG CONJUGATION; DRUG MECHANISM; ENDOTHELIUM; ENZYME ACTIVATION; ENZYME REPRESSION; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; LEUKOCYTE; LIPID PEROXIDATION; LYMPHOCYTE; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; RAT MODEL; REPERFUSION INJURY; UPREGULATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; KIDNEY; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; GLUCOSAMINE; IMP DEHYDROGENASE; INTERLEUKIN-6; KIDNEY; MALE; MYCOPHENOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907987499     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500282g     Document Type: Article

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