Neonatal and infant beta cell hormone concentrations in relation to type 1 diabetes risk

Pediatric Diabetes

Volumn 15, Issue 7, 2014, Pages 528-533

  Stumpp, Christian ^a,b   Beyerlein, Andreas ^c   Ziegler, Anette Gabriele ^c   Bonifacio, Ezio ^a,b  

^a CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^b GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Autoantibodies; Insulin; Proinsulin; Type 1 diabetes

Indexed keywords

C PEPTIDE; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; GLUTEN; HORMONE PRECURSOR; INSULIN ANTIBODY; PROINSULIN; AUTOANTIBODY; INSULIN;

ARTICLE; AUTOIMMUNITY; BIRTH WEIGHT; BREAST FEEDING; CHILD; CONTROLLED STUDY; FIRST DEGREE RELATIVE; FOLLOW UP; GESTATIONAL AGE; HLA SYSTEM; HUMAN; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; NEWBORN DISEASE; PANCREAS ISLET BETA CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RISK FACTOR; SEROCONVERSION; BLOOD; CHILD DEVELOPMENT; DIABETES MELLITUS, TYPE 1; FEMALE; FETOMATERNAL TRANSFUSION; FETUS DEVELOPMENT; GERMANY; IMMUNOLOGY; INCIDENCE; INFANT; LONGITUDINAL STUDY; MALE; NEWBORN; PATHOPHYSIOLOGY; PREGNANCY; PREGNANCY DIABETES MELLITUS; RISK; SECRETION (PROCESS);

AUTOANTIBODIES; AUTOIMMUNITY; C-PEPTIDE; CHILD DEVELOPMENT; DIABETES MELLITUS, TYPE 1; FEMALE; FETAL DEVELOPMENT; GERMANY; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; INSULIN; INSULIN-SECRETING CELLS; LONGITUDINAL STUDIES; MALE; MATERNAL-FETAL EXCHANGE; PREGNANCY; PREGNANCY IN DIABETICS; PROINSULIN; RISK;

EID: 84907953430     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/pedi.12122     Document Type: Article

References (19)

1. Ziegler A-G, Bonifacio E. BABYDIAB-BABYDIET study group. Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia 2012: 55: 1978-1984.
2. Parikka V, Nanto-Salonen K, Saarinen M et al. Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk. Diabetologia 2012: 55: 1926-1936.
3. Bonifacio E, Pflüger M, Marienfeld S, Winkler C, Hummel M, Ziegler A-G. Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with birthweight and maternal HbA(1c). Diabetologia 2008: 51: 1245-1252.
4. Fleury Y, Van Melle G, Woringer V, Gaillard RC, Portmann L. Sex-dependent variations and timing of thyroid growth during puberty. J Clin Endocrinol Metab 2001: 86: 750-754.
5. Kassem SA, Ariel I, Thornton PS, Scheimberg I, Glaser B. Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. Diabetes 2000: 49: 1325-1333.
6. Socha P, Grote V, Gruszfeld D et al. Milk protein intake, the metabolic-endocrine response, and growth in infancy: data from a randomized clinical trial. Am J Clin Nutr 2011: 94: 1776S-1784S.
7. Lindsay RS, Walker JD, Halsall I et al. Insulin and insulin propeptides at birth in offspring of diabetic mothers. J Clin Endocrinol Metab 2003: 88: 1664-1671.
8. Hummel S, Pflüger M, Hummel M, Bonifacio E, Ziegler A-G. Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study. Diabetes Care 2011: 34: 1301-1305.
9. Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 1999: 48: 460-468.
10. Achenbach P, Lampasona V, Landherr U et al. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 2009: 52: 1881-1888.
11. Singer JD, Willett JB. Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence. Oxford; New York: Oxford University Press, 2003.
12. Akaike H. New look at statistical-model identification. IEEE Trans Automat Contr. 1974: Ac19: 716-723.
13. Truyen I, De Pauw P, Jørgensen PN et al. Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes. Diabetologia 2005: 48: 2322-2329.
14. Pfützner A, Forst T. Elevated intact proinsulin levels are indicative of beta-cell dysfunction, insulin resistance, and cardiovascular risk: impact of the antidiabetic agent pioglitazone. J Diabetes Sci Technol 2011: 5: 784-793.
15. Butte NF, Garza C, Burr R, Goldman AS, Kennedy K, Kitzmiller JL. Milk composition of insulin-dependent diabetic women. J Pediatr Gastroenterol Nutr 1987: 6: 936-941.
16. Whitmore TJ, Trengove NJ, Graham DF, Hartmann PE. Analysis of insulin in human breast milk in mothers with type 1 and type 2 diabetes mellitus. Int J Endocrinol 2012: 1-9.
17. Warram JH, Krolewski AS, Gottlieb MS, Kahn CR. Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N Engl J Med 1984: 311: 149-152.
18. el-Hashimy M, Angelico MC, Martin BC, Krolewski AS, Warram JH. Factors modifying the risk of IDDM in offspring of an IDDM parent. Diabetes 1995: 44: 295-299.
19. Bonifacio E, Hummel M, Walter M, Schmid S, Ziegler AG. IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes. Diabetes Care 2004: 27: 2695-2700.