Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 41, 2014, Pages 14687-14692

  Trzoss, Lynnie ^a   Fukuda, Takashi ^a   Costa Lotufo, Letícia V ^a,b   Jimenez, Paula ^b   La Clair, James J ^c   Fenical, William ^a,d   Meinwald, Jerrold ^e  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e Cornell University ^*  (United States)

Author keywords

Cancer; Chemical biology; Drug discovery; Marine natural products; Mode of action

Indexed keywords

ANTINEOPLASTIC AGENT; DERMCIDIN; QUINONE DERIVATIVE;

AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; AUTOPHAGY; CELL CYCLE; CELL FRACTIONATION; CHEMISTRY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; HCT116 CELL LINE; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOLECULARLY TARGETED THERAPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHAGOCYTOSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; SYNTHESIS;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL CYCLE; DERMCIDINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HCT116 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MOLECULAR TARGETED THERAPY; PHAGOCYTOSIS; QUINONES; SUBCELLULAR FRACTIONS;

EID: 84907921201     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410932111     Document Type: Article

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