Plasma and liver lipid profiles in rats exposed to chronic hypobaric hypoxia: Changes in metabolic pathways

High Altitude Medicine and Biology

Volumn 15, Issue 3, 2014, Pages 388-395

  Siques, Patricia ^a   Brito, Julio ^a   Naveas, Nelson ^a   Pulido, Ruth ^a   De La Cruz, Juan José ^b   Mamani, Maribel ^a   León Velarde, Fabiola ^c  

^a UNIVERSIDAD ARTURO PRAT   (Chile)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

Author keywords

blood lipids; chronic hypoxia; high altitude; HMG CoA reductase; SCD 1

Indexed keywords

CHOLESTEROL; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; ACYL COENZYME A DESATURASE; BIOLOGICAL MARKER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; STEAROYL-COA DESATURASE SCD-1, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHRONIC DISEASE; CHRONIC HYPOBARIC HYPOXIA; CONTROLLED STUDY; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HYPOBARISM; HYPOXIA; LIPID LIVER LEVEL; LIPID METABOLISM; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WEIGHT REDUCTION; ANIMAL; ANOXIA; ENZYMOLOGY; EVALUATION STUDY; LIVER; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; ANOXIA; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CHOLESTEROL; CHRONIC DISEASE; HEMATOCRIT; HEMOGLOBINS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIVER; MALE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEAROYL-COA DESATURASE; TRIGLYCERIDES; UP-REGULATION;

EID: 84907911858     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2013.1134     Document Type: Article

References (39)

1. Böttiger LE, and Carlson LA. (1972). Relation between serum cholesterol and triglyceride concentration and haemoglobin values in non-Anemic healthy persons. BMJ 3:731-733.
2. Brito J, Siques P, Leon-Velarde F, De La Cruz JJ, Lopez V, and Herruzo R. (2007). Chronic intermittent hypoxia at high altitude exposure for over 12 years: Assessment of hematological, cardiovascular, and renal effects. High Alt Med Biol 8:236-244.
3. Brito J, Siques P, Leon-Velarde F, De La Cruz JJ, Barlaro T, Lopez V, and Herruzo R. (2008). Varying exposure regimes to long term chronic intermittent hypoxia exert different outcomes and morphological effects on Wistar rats at 4600 m. Toxicol Environ Chem 90:169-179.
4. Bruder ED, Lee PC, and Raff H. (2005). Lipid and fatty acid profiles in the brain, liver, and stomach contents of neonatal rats: Effects of hypoxia. Am J Physiol Endocrinol Metab 288:314-320.
5. Caceres J, Rojas M, Caceres L. and Ortiz J. (2004). Total cholesterol and its fractions in adults of 30 to 39 years, according to gender and sub-groups of age. Situa 13:12-19.
6. Calbet JA. (2003). Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans. J Physiol 551:379-386.
7. Choi JW, Kim SK, and Pai SH. (2001). Changes in serum lipid concentrations during iron depletion and after iron supplementation. Ann Clin Lab Sci 31:151-156.
8. Dominguez Coello S, Cabrera De Leon A, Bosa Ojeda F, Perez Mendez LI, Diaz Gonzalez L, and Aguirre-Jaime AJ. (2000). High density lipoprotein cholesterol increases with living altitude. Int J Epidemiol 29:65-70.
9. Drager LF, Li J, Shin MK, Reinke C, Aggarwal NR, Jun JC, Bevans-Fonti S, Sztalryd C, O'Byrne SM, Kroupa O, Olivecrona G, Blaner WS, and Polotsky VY. (2012). Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea. Eur Heart J 33:783-790.
10. Folch J, Lees M, and Sloane Stanley GH. (1957). A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509.
11. Grocott M, Montgomery H, and Vercueil A. (2007). High-Altitude physiology and pathophysiology: Implications and relevance for intensive care medicine. Crit Care 11:203.
12. Jha SK, Anand AC, Sharma V, Kumar N, and Adya CM. (2002). Stroke at high altitude: Indian experience. High Alt Med Biol 3:21-27.
13. Johns C, Gavras I, Handy DE, Salomao A, and Gavras H. (1996). Model of experimental hypertension in mice. Hypertension 28:1064-1069.
14. Jun JC, Shin MK, Yao Q, Devera R, Fonti-Bevans S,and Polotsky VY. (2013). Thermoneutrality modifies the impact of hypoxia on lipid metabolism. AmJ Physiol Endocrinol Metab 304:E424-435.
15. Kanstrup IL, Poulsen T, Hansen JM, Andersen LJ, Bestle MH, Christensen NJ, and Olsen NV. (1999). Blood pressure and plasma catecholamines in acute and prolonged hypoxia: Effects of local hypothermia. J Appl Physiol 87:2053-2058.
16. Li J, Grigoryev DN, Ye SQ, Thorne L, Schwartz AR, Smith PL, O'Donnell CP, and Polotsky VY. (2005a). Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice. J Appl Physiol 99:1643-1648.
17. Li J, Thorne LN, Punjabi NM, Sun CK, Schwartz AR, Smith PL, Marino RL, Rodriguez A, Hubbard WC, O'Donnell CP, and Polotsky VY. (2005b). Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 97:698-706.
18. Li J, Bosch-Marce M, Nanayakkara A, Savransky V, Fried SK, Semenza GL, and Polotsky VY. (2006). Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha. Physiol Genomics 25:450-457.
19. Li J, Nanayakkara A, Jun J, Savransky V, and Polotsky VY. (2007a). Effect of deficiency in SREBP cleavage-Activating protein on lipid metabolism during intermittent hypoxia. Physiol Genomics 31:273-280.
20. Li J, Savransky V, Nanayakkara A, Smith PL, O'Donnell CP, and Polotsky VY. (2007b).Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia. J Appl Physiol 102:557-563.
21. Mohanna S, Baracco R, and Seclen S. (2006). Lipid profile, waist circumference, and body mass index in a high altitude population. High Alt Med Biol 7:245-255.
22. Ness GC, and Chambers CM. (2000). Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: The concept of cholesterol buffering capacity. Proc Soc Exp Biol Med 224:8-19.
23. Niermeyer S, Zamudio S, and Moore IG. (2001). The people. In: High Altitude: An Exploration of Human Adaptation (Lung). Biology in Health and Disease, vol. 161. TF Hormbein and RB Schoene, eds. Marcel Dekker, New York; pp. 43-100.
24. Perry JC, D'Almeida V, Souza FG, Schoorlemmer GH, Colombari E, and Tufik S. (2007). Consequences of subchronic and chronic exposure to intermittent hypoxia and sleep deprivation on cardiovascular risk factors in rats. Respir Physiol Neurobiol156:250-258.
25. Qu AJ, Taylor M, Xue X, Matsubara T, Metzger D, Chambon P, Gonzalez FJ, and Shah YM. (2011). Hypoxia-inducible transcription factor 2 alpha promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology 54:472-483.
26. Reeves JT, and León-Velarde F. (2004). Chronic mountain sickness: Recent studies of the relationship between hemoglobin concentration and oxygen transport. High Alt Med Biol 5:147-155.
27. Savransky V, Nanayakkara A, Li J, Bevans S, Smith PL, Rodriguez A, and Polotsky VY. (2007a). Chronic intermittent hypoxia induces atherosclerosis. Am J Respir Crit Care Med 175:1290-1297.
28. Savransky V, Nanayakkara A, Vivero A, Li J, Bevans S, Smith PL, Torbenson MS, and Polotsky VY. (2007b).Chronic intermittent hypoxia predisposes to liver injury. Hepatology 45:1007-1013.
29. Sharma S. (1990). Clinical, biochemical, electrocardiographic and noninvasive hemodynamic assessment of cardiovascular status in natives at high to extreme altitudes (3000m-5500m) of the Himalayan region. Indian Heart J 42:375-379.
30. Sherpa LY, Deji Stigum H, Chongsuvivatwong V, Nafstad P, and Bjertness E. (2013). Prevalence of metabolic syndrome and common metabolic components in high altitude farmers and herdsmen at 3700m in Tibet. High Alt Med Biol 14:37-44.
31. Shimano H. (2001). Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40:439-452.
32. Sierra-Johnson J, Romero-Corral A, Somers VK, and Johnson BD. (2008). Effect of altitude on leptin levels, does it go up or down?. J Appl Physiol 105:1684-1685.
33. Siques P, Brito J, Leon-Velarde F, Barrios L, Cruz JJ, Lopez V, and Herruzo R. (2006). Time course of cardiovascular and hematological responses in rats exposed to chronic intermittent hypobaric hypoxia (4600 m). High Alt Med Biol 7:72-80.
34. Siques P, Brito J, Leon-Velarde F, Barrios L, De La Cruz JJ, Lopez V, and Herruzo R. (2007). Hematological and lipid profile changes in sea-level natives after exposure to 3550-m altitude for 8 months. High Alt Med Biol 8:286-295.
35. Temte JL. (1996). Elevation of serum cholesterol at high altitude and its relationship to hematocrit. Wilderness Environ Med 7:216-224.
36. Tschop M, Strasburger CJ, Hartmann G, Biollaz J, and Bartsch P. (1998). Raised leptin concentrations at high altitude associated with loss of appetite. Lancet 352:1119-1120.
37. Vats P, Ray K, Majumadar D, Amitabh, Joseph DA, Bayen S, Akunov A, Sarbaev A, and Singh SB. (2013). Changes in cardiovascular function, lipid profile, and body composition at high altitude in two different ethnic groups. High Alt Med Biol 14:45-52.
38. Yao Q, Shin MK, Jun JC, Hernandez KL, Aggarwal NR, Mock JR, Gay J, Drager LF, and Polotsky VY. (2013). Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues. J Lipid Res 54:1058-1065.
39. Yokode M, Hammer RE, Ishibashi S, Brown MS, and Goldstein JL. (1990). Diet-induced hypercholesterolemia in mice: Prevention by overexpression of LDL receptors. Science 250: 1273-1275.