Splenic lymph follicles generate immunoglobulin M-producing B cells in primary biliary cirrhosis

Hepatology Research

Volumn 44, Issue 10, 2014, Pages E253-E256

  Kikuchi, Kentaro ^a   Tsuneyama, Koichi ^b   Yamada, Hanae ^a   Kajiyama, Yusuke ^a   Matsumoto, Kotaro ^a   Tsunashima, Hiromichi ^a   Yamashita, Risa ^a   Takai, Atsuko ^a   Negishi, Masatsugu ^a   Hara, Masumi ^a   Moritoki, Yuki ^c   Miyakawa, Hiroshi ^a  

^a TEIKYO UNIVERSITY MIZONOKUCHI HOSPITAL   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c AKITA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Immunoglobulin M; Immunoglobulin M memory B cell; Lymph follicle; Primary biliary cirrhosis; Spleen

Indexed keywords

COMPLEMENT COMPONENT C3D RECEPTOR; CXCL13 CHEMOKINE; IMMUNOGLOBULIN M;

AGED; ARTICLE; B LYMPHOCYTE; CHRONIC HEPATITIS C; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER FAILURE; LYMPH FOLLICLE; MALE; PRIMARY BILIARY CIRRHOSIS; SPLEEN LYMPH NODE;

EID: 84907876113     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.12231     Document Type: Article

References (20)

1. Gershwin ME, Mackay IR, Sturgess A, Coppel RL. Identification and specificity of a cDNA encoding the 70kd mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol 1987; 138: 3525-3531.
2. Selmi C, Zuin M, Gershwin ME. The unfinished business of primary biliary cirrhosis. J Hepatol 2008; 49: 451-460.
3. Kikuchi K, Lian ZX, Yang GX etal. Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis. Gastroenterology 2005; 128: 304-312.
4. Mao TK, Lian ZX, Selmi C etal. Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis. Hepatology 2005; 42: 802-808.
5. Harada K, Nakanuma Y. Biliary innate immunity and cholangiopathy. Hepatol Res 2007; 37 (Suppl 3): S430-437.
6. Kawai T, Hosoya N, Moritoki Y etal. Autoantibody IgG subclasses to recombinant antigens and the role of bacterial stimuli in primary biliary cirrhosis. Hepatol Res 2009; 39: 874-881.
7. Shimoda S, Harada K, Niiro H etal. Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis. Hepatology 2011; 53: 1270-1281.
8. Agematsu K, Nagumo H, Oguchi Y etal. Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27/CD70 interaction. Blood 1998; 91: 173-180.
9. Klein U, Rajewsky K, Küppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998; 188: 1679-1689.
10. Aranburu A, Ceccarelli S, Giorda E etal. TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells. J Immunol 2010; 185: 7293-7301.
11. Kruetzmann S, Rosado MM, Weber H etal. Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J Exp Med 2003; 197: 939-945.
12. Good KL, Avery DT, Tangye SG. Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells. J Immunol 2009; 182: 890-901.
13. Ansel KM, Ngo VN, Hyman PL etal. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 2000; 406: 309-314.
14. Ide T. Studies on elevated serum IgM levels in primary biliary cirrhosis. Kanzou 1990; 31: 1315-1323.
15. Daniels JA, Torbenson M, Anders RA etal. Immunostaining of plasma cells in primary biliary cirrhosis. Am J Clin Pathol 2009; 131: 243-249.
16. Moreira RK, Revetta F, Koehler E etal. Diagnostic utility of IgG and IgM immunohistochemistry in autoimmune liver disease. World J Gastroenterol 2010; 16: 453-457.
17. Takahashi T, Miura T, Nakamura J etal. Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis. Hepatology 2012; 55: 846-855.
18. You Z, Wang Q, Bian Z etal. The immunopathology of liver granulomas in primary biliary cirrhosis. J Autoimmun 2012; 39: 216-221.
19. Moritoki Y, Lian ZX, Lindor K etal. B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice. Hepatology 2009; 50: 1893-1903.
20. Tsuda M, Moritoki Y, Lian ZX etal. Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid. Hepatology 2012; 55: 512-521.