Gene delivery of bone morphogenetic protein-2 plasmid DNA promotes bone formation in a large animal model

Journal of Tissue Engineering and Regenerative Medicine

Volumn 8, Issue 10, 2014, Pages 763-770

  Wegman, Fiona ^a   Geuze, Ruth E ^a   van der Helm, Yvonne J ^a   Cumhur Oner F ^a   Dhert, Wouter J A ^a,b   Alblas, Jacqueline ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Alginate hydrogel; Bone morphogenetic protein; Bone tissue engineering; Gene therapy; Gene activated matrix; Plasmid DNA

Indexed keywords

ALGINATE; ANIMALS; BONE; CYTOLOGY; DNA; GENE THERAPY; GENE TRANSFER; HYDROGELS; PROTEINS; TISSUE ENGINEERING;

ALGINATE HYDROGELS; ANIMAL MODEL; BONE FORMATION; BONE MORPHOGENETIC PROTEINS; BONE TISSUE ENGINEERING; GENE DELIVERY; GENE-ACTIVATED MATRIX; ORTHOTOPIC; PLASMID DNA; STROMAL CELLS;

BIOMOLECULES;

ALGINIC ACID; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COMPLEMENTARY DNA; PLASMID DNA; HYDROGEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DAIRY GOAT; FEASIBILITY STUDY; FEMALE; GENE TARGETING; HYDROGEL; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; ORTHOTOPIC TRANSPLANTATION; OSSIFICATION; PRIORITY JOURNAL; ANIMAL; AUTOGRAFT; BIOSYNTHESIS; BONE DEVELOPMENT; CELL CULTURE; GENE TRANSFER; GENETICS; GOAT; IMMOBILIZED CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; PHARMACOLOGY; PLASMID; TRANSPLANTATION;

ALGINATES; ANIMALS; AUTOGRAFTS; BONE MORPHOGENETIC PROTEIN 2; CELLS, CULTURED; CELLS, IMMOBILIZED; DNA, COMPLEMENTARY; GENE TRANSFER TECHNIQUES; GOATS; HYDROGELS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; PLASMIDS;

EID: 84907874332     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1571     Document Type: Article

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