Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 21, Issue 4, 2014, Pages 653-661

  Kao, Ting Hsien ^a,c,d   Peng, Yi Jen ^b   Tsou, Hsi Kai ^c,d   Salter, Donald M ^e   Lee, Herng Sheng ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d JEN TEH JUNIOR COLLEGE OF MEDICINE   (Taiwan)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chitinase 3 like 1; Intervertebral disc degeneration; Lipocalin 2; MMP3; Nerve growth factor

Indexed keywords

ANGIOGENESIS INHIBITOR; CHITINASE; CHITINASE 3 LIKE 1; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE GROWTH FACTOR; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; RO 082750; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; UNCLASSIFIED DRUG; CHI3L1 PROTEIN, RAT; GLYCOPROTEIN; LCN2 PROTEIN, RAT; LIPOCALIN; MAPK1 PROTEIN, RAT; PTERIDINE DERIVATIVE; RO 08-2750; SCLEROPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SIGNALING ASSAY; CELL STIMULATION; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK CELL; INTERVERTEBRAL DISK DEGENERATION; LOW BACK PAIN; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SIGNAL TRANSDUCTION; TAIL; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; GENETICS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC DEGENERATION; MALE; METABOLISM; PHOSPHORYLATION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BLOTTING, WESTERN; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC DEGENERATION; LIPOCALINS; MALE; MATRIX METALLOPROTEINASE 3; MICROARRAY ANALYSIS; MITOGEN-ACTIVATED PROTEIN KINASE 1; NERVE GROWTH FACTOR; PHOSPHORYLATION; PTERIDINES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84907861401     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2014.6.SPINE13756     Document Type: Article

References (45)

1. Andersson GB: Epidemiological features of chronic low-back pain. Lancet 354:581-585, 1999.
2. Ashton IK, Roberts S, Jaffray DC, Polak JM, Eisenstein SM: Neuropeptides in the human intervertebral disc. J Orthop Res 12:186-192, 1994.
3. Barthel C, Yeremenko N, Jacobs R, Schmidt RE, Bernateck M, Zeidler H, et al: Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis. Arthritis Res Ther 11:R82, 2009.
4. Benny B, Azari P: The efficacy of lumbosacral transforaminal epidural steroid injections: A comprehensive literature review. J Back Musculoskeletal Rehabil 24:67-76, 2011.
5. Boswell MV, Trescot AM, Datta S, Schultz DM, Hansen HC, Abdi S, et al: Interventional techniques: evidence-based practice guidelines in the management of chronic spinal pain. Pain Physician 10:7-111, 2007.
6. Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM: Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 84:196-201, 2002.
7. Carragee EJ: Clinical practice. Persistent low back pain. N Engl J Med 352:1891-1898, 2005.
8. Chacón PJ, Arévalo MA, Tébar AR: NGF-activated protein tyrosine phosphatase 1B mediates the phosphorylation and degradation of I-κ-Bα coupled to NF-κ-B activation, thereby controlling dendrite morphology. Mol Cell Neurosci 43:384- 393, 2010.
9. Coppes MH, Marani E, Thomeer RT, Groen GJ: Innervation of painful lumbar discs. Spine (Phila Pa 1976) 22:2342- 2350, 1997.
10. Coric D, Pettine K, Sumich A, Boltes MO: Prospective study of disc repair with allogeneic chondrocytes. Clinical article. J Neurosurg Spine 18:85-95, 2013.
11. Davis TT, Delamarter RB, Sra P, Goldstein TB: The IDET procedure for chronic discogenic low back pain. Spine (Phila Pa 1976) 29:752-756, 2004.
12. Deyo RA, Weinstein JN: Low back pain. N Engl J Med 344:363-370, 2001.
13. Freemont AJ, Peacock TE, Goupille P, Hoyland JA, O'Brien J, Jayson MI: Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 350:178-181, 1997.
14. Freemont AJ, Watkins A, Le Maitre C, Baird P, Jeziorska M, Knight MT, et al: Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol 197:286- 292, 2002.
15. Gupta K, Shukla M, Cowland JB, Malemud CJ, Haqqi TM: Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9. Arthritis Rheum 56:3326-3335, 2007.
16. Hakala BE, White C, Recklies AD: Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem 268:25803-25810, 1993.
17. Hempstead BL: The many faces of p75NTR. Curr Opin Neurobiol 12:260-267, 2002.
18. Horii M, Orita S, Nagata M, Takaso M, Yamauchi K, Yamashita M, et al: Direct application of the tumor necrosis factor-α inhibitor, etanercept, into a punctured intervertebral disc decreases calcitonin gene-related peptide expression in rat dorsal root ganglion neurons. Spine (Phila Pa 1976) 36:E80-E85, 2011.
19. Huang K, Wu LD: YKL-40: A potential biomarker for osteoarthritis. J Int Med Res 37:18-24, 2009.
20. Imai S, Matsusue Y: Neuronal regulation of bone metabolism and anabolism: calcitonin gene-related peptide-, substance P-, and tyrosine hydroxylase-containing nerves and the bone. Microsc Res Tech 58:61-69, 2002.
21. Iwata T, Kuwajima M, Sukeno A, Ishimaru N, Hayashi Y, Wabitsch M, et al: YKL-40 secreted from adipose tissue inhibits degradation of type I collagen. Biochem Biophys Res Commun 388:511-516, 2009.
22. Kallewaard JW, Terheggen MA, Groen GJ, Sluijter ME, Derby R, Kapural L, et al: 15. Discogenic low back pain. Pain Pract 10:560-579, 2010.
23. Khan KM, Falcone DJ, Kraemer R: Nerve growth factor activation of Erk-1 and Erk-2 induces matrix metalloproteinase-9 expression in vascular smooth muscle cells. J Biol Chem 277:2353-2359, 2002.
24. Kivitz AJ, Gimbel JS, Bramson C, Nemeth MA, Keller DS, Brown MT, et al: Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain. Pain 154: 1009-1021, 2013.
25. Kuisma M, Karppinen J, Niinimäki J, Ojala R, Haapea M, Heliövaara M, et al: Modic changes in endplates of lumbar vertebral bodies: prevalence and association with low back and sciatic pain among middle-aged male workers. Spine (Phila Pa 1976) 32:1116-1122, 2007.
26. Lambiase A, Rama P, Bonini S, Caprioglio G, Aloe L: Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med 338:1174-1180, 1998.
27. Lane NE, Schnitzer TJ, Birbara CA, Mokhtarani M, Shelton DL, Smith MD, et al: Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med 363:1521-1531, 2010.
28. Le Maitre CL, Pockert A, Buttle DJ, Freemont AJ, Hoyland JA: Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans 35:652-655, 2007.
29. Ling H, Recklies AD: The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha. Biochem J 380:651-659, 2004.
30. Micera A, Lambiase A, Stampachiacchiere B, Bonini S, Bonini S, Levi-Schaffer F: Nerve growth factor and tissue repair remodeling: TrkA(NGFR) and p75(NTR), two receptors one fate. Cytokine Growth Factor Rev 18:245-256, 2007.
31. Miyagi M, Ishikawa T, Kamoda H, Suzuki M, Murakami K, Shibayama M, et al: ISSLS Prize Winner: Disc dynamic compression in rats produces long-lasting increases in inflammatory mediators in discs and induces long-lasting nerve injury and regeneration of the afferent fibers innervating discs: A pathomechanism for chronic discogenic low back pain. Spine (Phila Pa 1976) 37:1810-1818, 2012.
32. Nico B, Mangieri D, Benagiano V, Crivellato E, Ribatti D: Nerve growth factor as an angiogenic factor. Microvasc Res 75:135-141, 2008.
33. Okada Y, Eibl G, Guha S, Duffy JP, Reber HA, Hines OJ: Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis 21:285-292, 2004.
34. Owen HC, Roberts SJ, Ahmed SF, Farquharson C: Dexamethasone- induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes. Am J Physiol Endocrinol Metab 294:E1023-E1034, 2008.
35. Pozzuoli A, Valvason C, Bernardi D, Plebani M, Fabris Monterumici D, Candiotto S, et al: YKL-40 in human lumbar herniated disc and its relationships with nitric oxide and cyclooxygenase- 2. Clin Exp Rheumatol 25:453-456, 2007.
36. Recklies AD, Ling H, White C, Bernier SM: Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. J Biol Chem 280:41213-41221, 2005.
37. Rezaeian AH, Isokane T, Nishibori M, Chiba M, Hiraiwa N, Yoshizawa M, et al: αCGRP and βCGRP transcript amount in mouse tissues of various developmental stages and their tissue expression sites. Brain Dev 31:682-693, 2009.
38. Richardson SM, Purmessur D, Baird P, Probyn B, Freemont AJ, Hoyland JA: Degenerate human nucleus pulposus cells promote neurite outgrowth in neural cells. PLoS ONE 7:e47735, 2012.
39. Sanga P, Katz N, Polverejan E, Wang S, Kelly KM, Haeussler J, et al: Efficacy, safety, and tolerability of fulranumab, an antinerve growth factor antibody, in the treatment of patients with moderate to severe osteoarthritis pain. Pain 154:1910-1919, 2013.
40. Triebel S, Bläser J, Reinke H, Tschesche H: A 25 kDa α2- microglobulin-related protein is a component of the 125 kDa form of human gelatinase. FEBS Lett 314:386-388, 1992.
41. Tschesche H, Zölzer V, Triebel S, Bartsch S: The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases. Eur J Biochem 268:1918-1928, 2001.
42. Tsou HK, Chao SC, Wang CJ, Chen HT, Shen CC, Lee HT, et al: Percutaneous pulsed radiofrequency applied to the L-2 dorsal root ganglion for treatment of chronic low-back pain: 3-year experience. Clinical article. J Neurosurg Spine 12:190-196, 2010.
43. Volck B, Ostergaard K, Johansen JS, Garbarsch C, Price PA: The distribution of YKL-40 in osteoarthritic and normal human articular cartilage. Scand J Rheumatol 28:171-179, 1999.
44. Zhang Y, Chee A, Thonar EJ, An HS: Intervertebral disk repair by protein, gene, or cell injection: A framework for rehabilitation- focused biologics in the spine. PM R 3 (6 Suppl 1): S88-S94, 2011.
45. Zhou XF, Deng YS, Chie E, Xue Q, Zhong JH, McLachlan EM, et al: Satellite-cell-derived nerve growth factor and neurotrophin- 3 are involved in noradrenergic sprouting in the dorsal root ganglia following peripheral nerve injury in the rat. Eur J Neurosci 11:1711-1722, 1999.