YKL-40 in human lumbar herniated disc and its relationships with nitric oxide and cyclooxygenase-2

Clinical and Experimental Rheumatology

Volumn 25, Issue 3, 2007, Pages 453-456

  Pozzuoli, Assunta ^a   Valvason, Chiara ^b   Bernardi, Daniel ^c   Plebani, Mario ^c   Monterumici, D Fabris ^c   Candiotto, Sergio ^d   Aldegheri, Roberto ^a   Punzi, Leonardo ^b  

^a Orthopaedic Clinic   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^d Hospital of Dolo (VE)   (Italy)

Author keywords

COX 2; Low back pain; Lumbar disc herniation; NO; YKL 40

Indexed keywords

CHITINASE 3 LIKE PROTEIN 1; CYCLOOXYGENASE 2; GLYCOPROTEIN; NITRIC OXIDE; PROTEIN YKL 40; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; DISEASE MARKER; DRY WEIGHT; FEMALE; HUMAN; HUMAN TISSUE; HYPOTHESIS; INFLAMMATION; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISKECTOMY; LOW BACK PAIN; LUMBAR DISK HERNIA; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECRETION; TISSUE CULTURE; TISSUE LEVEL;

ADULT; AGED; BIOLOGICAL MARKERS; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOPROTEINS; HUMANS; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; NITRIC OXIDE;

EID: 34447637632     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. ANDERSSON GB: Epidemiological features of chronic low-back pain. Lancet 1999; 354: 581-5.
2. HURRI H, KARPPINEN J: Discogenic pain. Pain 2004; 112:225-8.
3. FREEMONT AJ, WATKINS A, LE MAITRE C, JEZIORSKA M, HOYLAND JA: Current understanding of cellular and molecular events in intervertebral disc degeneration: Implications for therapy. J Pathol 2002; 196: 374-9.
4. THELANDER U, FAGERLUND M, FRIBERG S, LARSSON S: Straight leg raising test vs radiological size, shape and position of lumbar disc herniations. Spine 1992; 17: 395-9.
5. SAAL JA, SAAL JS, HERZOG RI: The natural history of lumbar intervertehral disc extrusions treated nonoperatively. Spine 1990; 15: 683-6.
6. BOGDUK N: A narrative review of intra-articular corticosteroid injections for low back pain. Pain Med 2005; 6: 287-96.
7. 2. Spine 1996; 21: 271-7.
8. TAKAHASHI H, SUGURO T, OKAZIMA Y, MOTEGI M, OKADA Y, KAKIUCHI T: Inflammatory cytokines in the herniated disc in the lumbar spine. Spine 1996; 21: 218-24.
9. MATSUI Y, MAEDA M, NAKAGAMI W, IWATA H: The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation. Spine 1998; 23: 863-8.
10. MIYAMOTO H, SAURA R, DOITA M, KUROSAKA M, MIZUNO K: The role of cyclooxygenase-2 in lumbar disc herniation. Spine 2002; 27: 2477-83.
11. HASHIZUME H, KAWAKAMI M, NISHI H, TAMAKI T: Histochemical demonstration of nitric oxide in herniated lumbar discs. A clinical and animal model study. Spine 1997; 22: 1080-4.
12. VOLCK B, JOHANSEN JS, STOLTENBERG M et al.: Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology. Osteoarthritis Cartilage 2001; 9: 203-14.
13. JOHANSEN JS, OLEE T, PRICE PA, HASHIMOTO S, OCHS RL, LOTZ M: Regulation of YKL-40 production by human articular chondrocytes. Arthritis Rheum 2001; 44: 826-37.
14. PUNZI L, PODSWIADEK M, D'INCÀ R, ZANINOTTO M, BERNARDI D, PLEBANI M, STURNIOLO GC: Serum human cartilage glycoprotein-39 as a marker of arthritis associated with inflammatory bowel diseases. Ann Rheum Dis 2003; 62: 1224-6.
15. DE CEUNINCK F, GAUFILLIER S, BONNAUD A, SABATINI M, LESUR C, PASTOUREAU P: YKL-40 (cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytes. Biochem Biophys Res Commun 2001; 285: 926-31.