Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils

Pharmacology Biochemistry and Behavior

Volumn 126, Issue , 2014, Pages 83-89

  Wang, Bei Yun ^a   Zhong, Yuan ^a   Zhao, Zhe ^a   Miao, Ya ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Amyloid fibrils; Brain derived neurotrophic factor; Histone deacetylase 2; Memory; Synaptic plasticity

Indexed keywords

AMYLOID; BRAIN DERIVED NEUROTROPHIC FACTOR; HISTONE DEACETYLASE 2; HISTONE H3; MESSENGER RNA; TRICHOSTATIN A; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); HISTONE; HYDROXAMIC ACID; PEPTIDE FRAGMENT;

ADULT; ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; EXON; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; HISTONE ACETYLATION; MALE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; RAT; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; EXPLORATORY BEHAVIOR; GENETIC EPIGENESIS; GENETICS; MAZE TEST; MEMORY; METABOLISM; PHYSIOLOGY;

ACETYLATION; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CA1 REGION, HIPPOCAMPAL; EPIGENESIS, GENETIC; EXCITATORY POSTSYNAPTIC POTENTIALS; EXPLORATORY BEHAVIOR; HISTONE DEACETYLASE 2; HISTONES; HYDROXAMIC ACIDS; MALE; MAZE LEARNING; MEMORY; PEPTIDE FRAGMENTS; PROMOTER REGIONS, GENETIC; RATS;

EID: 84907854885     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2014.09.009     Document Type: Article

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