C1q/TNF-related protein-3 (CTRP-3) attenuates lipopolysaccharide (LPS)-induced systemic inflammation and adipose tissue Erk-1/-2 phosphorylation in mice in vivo

Biochemical and Biophysical Research Communications

Volumn 452, Issue 1, 2014, Pages 8-13

  Schmid, Andreas ^a   Kopp, Andrea ^b   Hanses, Frank ^b   Karrasch, Thomas ^a   Schäffler, Andreas ^a  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Adipokine; Adipose tissue; CTRP 3; Erk 1 2; Inflammation; LPS

Indexed keywords

ADIPOCYTOKINE; ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; CHEMOKINE; COMPLEMENT COMPONENT C1Q; CTRP 3 PROTEIN; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; RECOMBINANT CTRP 3 PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; CORS26 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE;

ABDOMINAL FAT; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; EPIDIDYMIS FAT; GENE EXPRESSION; IN VIVO STUDY; INFLAMMATORY DISEASE; MOUSE; NONHUMAN; PERIRENAL FAT; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SOFT TISSUE INFLAMMATION; SUBCUTANEOUS FAT; SYSTEMIC DISEASE; SYSTEMIC INFLAMMATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADIPOKINES; ADIPOSE TISSUE; ANIMALS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; PHOSPHORYLATION;

EID: 84907819508     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.06.054     Document Type: Article

References (31)

1. A. Schaffler, U. Muller-Ladner, J. Scholmerich, and C. Buchler Role of adipose tissue as an inflammatory organ in human diseases Endocr. Rev. 27 2006 449 467
2. A. Schaffler, J. Scholmerich, and B. Salzberger Adipose tissue as an immunological organ: toll-like receptors, C1q/TNFs and CTRPs Trends Immunol. 28 2007 393 399
3. A. Schaffler, and C. Buechler CTRP family: linking immunity to metabolism Trends Endocrinol. Metab. 23 2012 194 204
4. L. Shapiro, and P.E. Scherer The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor Curr. Biol. 8 1998 335 338
5. A. Schaffler, A. Ehling, E. Neumann, H. Herfarth, I. Tarner, S. Gay, J. Scholmerich, and U. Muller-Ladner Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 (collagenous repeat-containing sequence of 26 kDa protein) Biochim. Biophys. Acta 1628 2003 64 70
6. J. Weigert, M. Neumeier, A. Schaffler, M. Fleck, J. Scholmerich, C. Schutz, and C. Buechler The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells FEBS Lett. 579 2005 5565 5570
7. T. Maeda, A. Jikko, M. Abe, T. Yokohama-Tamaki, H. Akiyama, S. Furukawa, M. Takigawa, and S. Wakisaka Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes J. Cell. Physiol. 206 2006 537 544
8. B. Wolfing, C. Buechler, J. Weigert, M. Neumeier, C. Aslanidis, J. Schoelmerich, and A. Schaffler Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines Obesity (Silver Spring) 16 2008 1481 1486
9. A. Schmid, A. Kopp, F. Hanses, M. Bala, M. Muller, and A. Schaffler The novel adipokine C1q/TNF-related protein-3 is expressed in human adipocytes and regulated by metabolic and infection-related parameters Exp. Clin. Endocrinol. Diabetes 120 2012 611 617
10. M. Hoch, A.N. Eberle, R. Peterli, T. Peters, D. Seboek, U. Keller, B. Muller, and P. Linscheid LPS induces interleukin-6 and interleukin-8 but not tumor necrosis factor-alpha in human adipocytes Cytokine 41 2008 29 37
11. A. Kopp, M. Bala, C. Buechler, W. Falk, P. Gross, M. Neumeier, J. Scholmerich, and A. Schaffler C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue Endocrinology 151 2010 5267 5278
12. A. Schmid, A. Kopp, C. Aslanidis, M. Wabitsch, M. Muller, and A. Schaffler Regulation and function of C1Q/TNF-related protein-5 (CTRP-5) in the context of adipocyte biology Exp. Clin. Endocrinol. Diabetes 121 2013 310 317
13. J.M. Peterson, M.M. Seldin, Z. Wei, S. Aja, and G.W. Wong CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism Am. J. Physiol. Gastrointest. Liver Physiol. 305 2013 G214 G224
14. J.M. Peterson, Z. Wei, and G.W. Wong C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output J. Biol. Chem. 285 2010 39691 39701
15. K.M. Choi, S.Y. Hwang, H.C. Hong, S.J. Yang, H.Y. Choi, H.J. Yoo, K.W. Lee, M.S. Nam, Y.S. Park, J.T. Woo, Y.S. Kim, D.S. Choi, B.S. Youn, and S.H. Baik C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome Diabetes 61 2012 2932 2936
16. A. Kopp, M. Bala, J. Weigert, C. Buchler, M. Neumeier, C. Aslanidis, J. Scholmerich, and A. Schaffler Effects of the new adiponectin paralogous protein CTRP-3 and of LPS on cytokine release from monocytes of patients with type 2 diabetes mellitus Cytokine 49 2010 51 57
17. S.A. Compton, and B. Cheatham CTRP-3: blocking a toll booth to obesity-related inflammation Endocrinology 151 2010 5095 5097
18. C. Hofmann, N. Chen, F. Obermeier, G. Paul, C. Buchler, A. Kopp, W. Falk, and A. Schaffler C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts Inflamm. Bowel Dis. 17 2011 2462 2471
19. R. Bhargava, C.J. Altmann, A. Andres-Hernando, R.G. Webb, K. Okamura, Y. Yang, S. Falk, E.P. Schmidt, and S. Faubel Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-alpha antibodies PLoS One 8 2013 e79037
20. S. Nishimura, I. Manabe, and R. Nagai Adipose tissue inflammation in obesity and metabolic syndrome Discov. Med. 8 2009 55 60
21. J.G. Neels, and J.M. Olefsky Inflamed fat: what starts the fire? J. Clin. Invest. 116 2006 33 35
22. C. Brenner, R.E. Simmonds, S. Wood, V. Rose, M. Feldmann, and J. Turner TLR signalling and adapter utilization in primary human in vitro differentiated adipocytes Scand. J. Immunol. 76 2012 359 370
23. S. Kato, Y. Yuzawa, N. Tsuboi, S. Maruyama, Y. Morita, T. Matsuguchi, and S. Matsuo Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of Toll-like receptor 4 J. Am. Soc. Nephrol. 15 2004 1289 1299
24. A. Kopp, P. Gross, W. Falk, M. Bala, J. Weigert, C. Buechler, M. Neumeier, J. Scholmerich, and A. Schaffler Fatty acids as metabolic mediators in innate immunity Eur. J. Clin. Invest. 39 2009 924 933
25. A. Kopp, C. Buechler, M. Neumeier, J. Weigert, C. Aslanidis, J. Scholmerich, and A. Schaffler Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes Obesity (Silver Spring) 17 2009 648 656
26. A. Kopp, C. Buechler, M. Bala, M. Neumeier, J. Scholmerich, and A. Schaffler Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3 Endocrinology 151 2010 1097 1108
27. M.A. Murayama, S. Kakuta, T. Maruhashi, K. Shimizu, A. Seno, S. Kubo, N. Sato, S. Saijo, M. Hattori, and Y. Iwakura CTRP3 plays an important role in the development of collagen-induced arthritis in mice Biochem. Biophys. Res. Commun. 443 2014 42 48
28. J.M. Moreno-Navarrete, X. Escote, F. Ortega, M. Serino, M. Campbell, M.C. Michalski, M. Laville, G. Xifra, E. Luche, P. Domingo, M. Sabater, G. Pardo, A. Waget, J. Salvador, M. Giralt, J.I. Rodriguez-Hermosa, M. Camps, C.I. Kolditz, N. Viguerie, J. Galitzky, P. Decaunes, W. Ricart, G. Fruhbeck, F. Villarroya, G. Mingrone, D. Langin, A. Zorzano, H. Vidal, J. Vendrell, R. Burcelin, A. Vidal-Puig, and J.M. Fernandez-Real A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction Diabetologia 56 2013 2524 2537
29. M. Alvehus, J. Buren, M. Sjostrom, J. Goedecke, and T. Olsson The human visceral fat depot has a unique inflammatory profile Obesity (Silver Spring) 18 2010 879 883
30. S.U. Amano, J.L. Cohen, P. Vangala, M. Tencerova, S.M. Nicoloro, J.C. Yawe, Y. Shen, M.P. Czech, and M. Aouadi Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation Cell Metab. 19 2014 162 171
31. C. Buechler, and A. Schaffler Does global gene expression analysis in type 2 diabetes provide an opportunity to identify highly promising drug targets? Endocr. Metab. Immune Disord. Drug Targets 7 2007 250 258