Mammary fat of breast cancer: Gene expression profiling and functional characterization

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Wang, Fengliang ^a   Gao, Sheng ^a   Chen, Fei ^a   Fu, Ziyi ^a   Yin, Hong ^a   Lu, Xun ^b   Yu, Jing ^a   Lu, Cheng ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b High School   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CYTOCHROME C OXIDASE; FATTY ACID BINDING PROTEIN 4; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCOUPLING PROTEIN 1; ADIPOCYTOKINE; FABP4 PROTEIN, HUMAN; FATTY ACID BINDING PROTEIN; HOMEODOMAIN PROTEIN; TUMOR PROTEIN;

ADIPOGENESIS; ADIPOQ GENE; ADULT; ARTICLE; BREAST; BREAST ATROPHY; BREAST CANCER; BREAST LESION; BROWN ADIPOSE TISSUE; CANCER GROWTH; CHINESE; CIDEA GENE; CONTROLLED STUDY; COX7A1 GENE; FABP4 GENE; FEMALE; FUNCTIONAL ASSESSMENT; GENE; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEP GENE; MAJOR CLINICAL STUDY; MAMMARY FAT; MCP 1 GENE; MIDDLE AGED; PRDM16 GENE; PROTEIN EXPRESSION; PROTEIN SECRETION; TBX1 GENE; TMEM26 GENE; UCP1 GENE; WESTERN BLOTTING; WHITE ADIPOSE TISSUE; BREAST TUMOR; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETICS; MAMMARY GLAND; METABOLISM; MICROARRAY ANALYSIS; PATHOLOGY; PRIMARY CELL CULTURE; STROMA CELL; TUMOR MICROENVIRONMENT;

ADIPOKINES; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ADULT; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FATTY ACID-BINDING PROTEINS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; MAMMARY GLANDS, HUMAN; MICROARRAY ANALYSIS; MIDDLE AGED; NEOPLASM PROTEINS; PRIMARY CELL CULTURE; STROMAL CELLS; TUMOR MICROENVIRONMENT;

EID: 84907812708     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109742     Document Type: Article

References (29)

1. Hovey RC, Aimo L (2010) Diverse and active roles for adipocytes during mammary gland growth and function. J Mammary Gland Biol Neoplasia 15:279-290.
2. Beckmann MW, Niederacher D, Schnurch HG, Gusterson BA, Bender HG (1997) Multistep carcinogenesis of breast cancer and tumour heterogeneity. J Mol Med (Berl) 75:429-439.
3. Russo IH, Russo J (1998) Role of hormones in mammary cancer initiation and progression. J Mammary Gland Biol Neoplasia 3:49-61.
4. Hovey RC, Trott JF, Vonderhaar BK (2002) Establishing a framework for the functional mammary gland: from endocrinology to morphology. J Mammary Gland Biol Neoplasia 7:17-38.
5. Watson CJ (2006) Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ. Breast Cancer Res 8:203.
6. Brisken C, Rajaram RD (2006) Alveolar and lactogenic differentiation. J Mammary Gland Biol Neoplasia 11:239-248.
7. Neville MC, Medina D, Monks J, Hovey RC (1998) The mammary fat pad. J Mammary Gland Biol Neoplasia 3:109-116.
8. Mueller MM, Fusenig NE (2004) Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4:839-849.
9. Joyce JA, Pollard JW (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer 9:239-252.
10. Bissell MJ, Hines WC (2011) Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 17:320-329.
11. Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84:277-359.
12. Cannon B, Nedergaard J (2008) Studies of thermogenesis and mitochondrial function in adipose tissues. Methods Mol Biol 456:109-121.
13. Lee P, Werner CD, Kebebew E, Celi FS (2014) Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes (Lond) 38:170-176.
14. Carey AL, Vorlander C, Reddy-Luthmoodoo M, Natoli AK, Formosa MF, et al. (2014) Reduced UCP-1 Content in In Vitro Differentiated Beige/Brite Adipocytes Derived from Preadipocytes of Human Subcutaneous White Adipose Tissues in Obesity. PLoS One 9:e91997.
15. Lago CU, Nowinski SM, Rundhaug JE, Pfeiffer ME, Kiguchi K, et al. (2012) Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis. Oncogene 31:4725-4731.
16. Robbins D, Zhao Y (2011) New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis. Int J Mol Sci 12:5285-5293.
17. Bujalska IJ, Kumar S, Hewison M, Stewart PM (1999) Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydro-genase. Endocrinology 140:3188-3196.
18. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods 25:402-408.
19. Wiseman BS, Werb Z (2002) Stromal effects on mammary gland development and breast cancer. Science 296:1046-1049.
20. Jodele S, Blavier L, Yoon JM, De Clerck YA (2006) Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression. Cancer Metastasis Rev 25:35-43.
21. Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52-67.
22. Rajala MW, Scherer PE (2003) Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144:3765-3773.
23. Dirat B, Bochet L, Dabek M, Daviaud D, Dauvillier S, et al. (2011) Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res 71:2455-2465.
24. Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, et al. (2006) High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int J Cancer 118:1414-1419.
25. Schaffler A, Scholmerich J, Buechler C (2007) Mechanisms of disease: adipokines and breast cancer - endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat Clin Pract Endocrinol Metab 3:345-354.
26. Gonzalez-Perez RR, Lanier V, Newman G (2013) Leptin's Pro-Angiogenic Signature in Breast Cancer. Cancers (Basel) 5:1140-1162.
27. Master SR, Hartman JL, D'Cruz CM, Moody SE, Keiper EA, et al. (2002) Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis. Mol Endocrinol 16:1185-1203.
28. Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, et al. (2013) Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. Cell Cycle 12:172-182.
29. Chen Y, Cairns R, Papandreou I, Koong A, Denko NC (2009) Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS One 4:e7033.