The beneficial effects of combined grape pomace and omija fruit extracts on hyperglycemia, adiposity and hepatic steatosis in db/db mice: A comparison with major index compounds

International Journal of Molecular Sciences

Volumn 15, Issue 10, 2014, Pages 17778-17789

  Cho, Su Jung ^a   Park, Hae Jin ^a   Jung, Un Ju ^a   Kim, Hye Jin ^b   Moon, Byoung Seok ^b   Choi, Myung Sook ^a  

^a Kyungpook National University   (South Korea)

^b CJ Corporation   (South Korea)

Author keywords

Adiposity; Grape pomace; Hepatic steatosis; Hyperglycemia; Omija fruit

Indexed keywords

GRAPE POMACE EXTRACT; OMIJA FRUIT EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; ADIPONECTIN; BIOLOGICAL MARKER; CYCLOOCTANE DERIVATIVE; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; INSULIN; LEPTIN; LIGNAN; POLYCYCLIC HYDROCARBON; RESISTIN; RESVERATROL; SCHIZANDRIN; STILBENE DERIVATIVE;

ADULT; ARTICLE; AWARENESS; CONGENITAL MALFORMATION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; EGYPT; FATTY LIVER; FEMALE; FEMALE WORKER; HEALTH LITERACY; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; INFORMATION PROCESSING; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEURAL TUBE DEFECT; OBESITY; PRENATAL CARE; QUESTIONNAIRE; STUDY DESIGN; UNIVARIATE ANALYSIS; VOCATIONAL EDUCATION; YOUNG ADULT; ANALYSIS; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; FRUIT; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; SCHISANDRA; VITIS;

MUS; VITACEAE;

ADIPONECTIN; ADIPOSITY; ANIMALS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CYCLOOCTANES; DIABETES MELLITUS, EXPERIMENTAL; FATTY LIVER; FRUIT; HEMOGLOBIN A, GLYCOSYLATED; HYPERGLYCEMIA; INSULIN; LEPTIN; LIGNANS; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; PLANT EXTRACTS; POLYCYCLIC COMPOUNDS; RESISTIN; SCHISANDRA; STILBENES; VITIS;

EID: 84907811136     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms151017778     Document Type: Article

References (30)

1. DeFronzo, R. A. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis. Neth. J. Med. 1997, 50, 191-197.
2. Petersen, K. F.; Oral, E. A.; Dufour, S.; Befroy, D.; Ariyan, C.; Yu, C.; Cline, G. W.; DePaoli, A. M.; Taylor, S. I.; Gorden, P.; et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Investig. 2002, 109, 1345-1350.
3. Petersen, K. F.; Dufour, S.; Befroy, D.; Lehrke, M.; Hendler, R. E.; Shulman, G. I. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 2005, 54, 603-608.
4. Monagas, M.; Gomez-Cordoves, C.; Bartolome, B.; Laureano, O.; Ricardo da Silva, J. M. Monomeric, oligomeric, and polymeric flavan-3-ol composition of wines and grapes from Vitis vinifera L. Cv. graciano, tempranillo, and cabernet sauvignon. J. Agric. Food Chem. 2003, 51, 6475-6481.
5. Khanal, R. C.; Howard, L. R.; Rogers, T. J.; Wilkes, S. E.; Dhakal, I. B.; Prior, R. L. Effect of feeding grape pomace on selected metabolic parameters associated with high fructose feeding in growing Sprague-Dawley rats. J. Med. Food 2011, 14, 1562-1569.
6. Lau, C. H.; Chan, C. M.; Chan, Y. W.; Lau, K. M.; Lau, T. W.; Lam, F. C.; Che, C. T.; Leung, P. C.; Fung, K. P.; Ho, Y. Y.; et al. In vitro antidiabetic activities of five medicinal herbs used in Chinese medicinal formulae. Phytother. Res. 2008, 22, 1384-1388.
7. Cho, S. J.; Jung, U. J.; Park, H. J.; Kim, H. J.; Park Y. B.; Kim, S. R.; Choi, M. S. Combined ethanol extract of grape pomace and omija fruit ameliorates adipogenesis, hepatic steatosis, and inflammation in diet-induced obese mice. Evid. Based Complement. Altern. Med. 2013, doi: 10. 1155/2013/212139.
8. Frémont, L. Biological effects of resveratrol. Life Sci. 2000, 66, 663-673.
9. Do, G. M.; Jung, U. J.; Park, H. J.; Kwon, E. Y.; Jeon, S. M.; McGregor, R. A.; Choi, M. S. Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice. Mol. Nutr. Food Res. 2012, 56, 1282-1291.
10. Park, S.; Hong, S. M.; Ahn, I. S.; Kim, Y. J.; Lee, J. B. Huang-Lian-Jie-Du-Tang supplemented with Schisandra chinensis Baill. and Polygonatum odoratum Druce improved glucose tolerance by potentiating insulinotropic actions in islets in 90% pancreatectomized diabetic rats. Biosci. Biotechnol. Biochem. 2009, 73, 2384-2392.
11. Argaud, D.; Zhang, Q.; Pan, W.; Maitra, S.; Pilkis, S. J.; Lange, A. J. Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: Gene structure and 5-flanking sequence. Diabetes 1996, 45, 1563-1571.
12. Park, S. A.; Choi, M. S.; Cho, S. Y.; Seo, J. S.; Jung, U. J.; Kim, M. J.; Sung, M. K.; Park, Y. B.; Lee, M. K. Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci. 2006, 79, 1207-1213.
13. Weir, G. C.; Bonner-Weir, S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 2004, 53, 16-21.
14. Matsuoka, T. A.; Kaneto, H.; Miyatsuka, T.; Yamamoto, T.; Yamamoto, K.; Kato, K.; Shimomura, I.; Stein, R.; Matsuhisa, M. Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes. Diabetes 2010, 59, 1709-1720.
15. Unger, R. H. Glucagon and the insulin: glucagon ratio in diabetes and other catabolic illnesses. Diabetes 1971, 20, 834-838.
16. Woods, S. C.; Seeley, R. J.; Porte, D. J.; Schwartz, M. W. Signals that regulate food intake and energy homeostasis. Science 1998, 280, 1378-1383.
17. Arner, P. Insulin resistance in type 2 diabetes-Role of the adipokines. Curr. Mol. Med. 2005, 5, 333-339.
18. Taube, A.; Schlich, R.; Sell, H.; Eckhardt, K.; Eckel, J. Inflammation and metabolic dysfunction: links to cardiovascular diseases. Am. J. Physiol. Heart Circ. Physiol. 2012, 302, 2148-2165.
19. Park, H. J.; Jung, U. J.; Lee, M. K.; Cho, S. J.; Jung, H. K.; Hong, J. H.; Park, Y. B.; Kim, S. R.; Shim, S.; Jung, J.; et al. Modulation of lipid metabolism by polyphenol-rich grape skin extract improves liver steatosis and adiposity in high fat fed mice. Mol. Nutr. Food Res. 2013, 57, 360-364.
20. Pan, S. Y.; Dong, H.; Zhao, X. Y.; Xiang, C. J.; Fang, H. Y.; Fong, W. F.; Yu, Z. L.; Ko, K. M. Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice. J. Pharm. Pharmacol. 2008, 60, 399-403.
21. Kabir, M.; Catalano, K. J.; Ananthnarayan, S.; Kim, S. P.; Van Citters, G. W.; Dea, M. K.; Bergman, R. N. Molecular evidence supporting the portal theory: A causative link between visceral adiposity and hepatic insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2005, 288, E454-E461.
22. Matthews, D. R.; Hosker, J. P.; Rudenski, A. S.; Naylor, B. A.; Treacher D. F.; Turner, R. C. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28, 412-419.
23. Hulcher, F. H.; Oleson, W. H. Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. J. Lipid Res. 1973, 14, 625-631.
24. Davidson, A. L.; Arion, W. J. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: Physiological implications of higher cellular activity. Arch. Biochem. Biophys. 1987, 253, 156-167.
25. Alegre, M.; Ciudad, C. J.; Fillat, C.; Guinovart, J. J. Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction. Anal. Biochem. 1988, 173, 185-189.
26. Bentle, L. A.; Lardy, H. A. Interaction of anions and divalent metal ions with phosphopyruvate carboxykinase. J. Biol. Chem. 1976, 251, 2916-2921.
27. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
28. Lazarow, P. B. Assay of peroxisomal β-oxidation of fatty acids. Methods Enzymol. 1981, 72, 315-319.
29. Carl, M. N.; Lakshmanan, M. R.; Porter, J. W. FAS from rat liver. Mothods Enzymol. 1975, 35, 37-44.
30. Pitkänen, E.; Pitkänen, O.; Uotila, L. Enzymatic determination of unbound D-mannose in serum. Eur. J. Clin. Chem. Clin. Biochem. 1997, 35, 761-766.