Study on the effect of BMSCs-EGFP-tk as mediator of HSV1-tk/GCV suicide gene therapy directed against A549 in vitro

International Journal of Clinical and Experimental Medicine

Volumn 7, Issue 9, 2014, Pages 3080-3086

  Yang, Kun ^a   Xu, Wen Gui ^a   Liu, Yong Zhe ^a   Meng, Xiang Rui ^a   Chen, Peng ^a   Wu, Li Chuan ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

BMSCs; Bystander effect; Co culture; HSV1 tk; Lung cancer

Indexed keywords

COMPLEMENTARY DNA; ENHANCED GREEN FLUORESCENT PROTEIN; GANCICLOVIR; LIPOFECTAMINE; MESSENGER RNA; RETROVIRUS VECTOR; THYMIDINE KINASE;

A549 CELL LINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BYSTANDER EFFECT; CANCER GENE THERAPY; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GENE; GENE EXPRESSION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1 THYMIDINE KINASE GENE; IN VITRO STUDY; LUNG ADENOCARCINOMA; MALE; MORTALITY; MOUSE; MRNA EXPRESSION ASSAY; MTT ASSAY; NONHUMAN; PROTEIN EXPRESSION; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUICIDE GENE THERAPY; SURVIVAL RATE;

EID: 84907809601     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Morimoto E, Inase N, Mlyake S, Yoshizawa Y. Adenovirus-mediated suicide gene transfer to small cell lung carcinoma using a tumor-specific promoter. Anticancer Res 2001; 21: 329-332.
2. Wang XP, Yazawa K, Yang J, Kohn D, Fisher WE, Brunicardi FC. Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter. Gastrointest Surg 2004; 8: 98-108.
3. Fischer U, Steffens S, Frank S. Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene 2005; 24: 1231-1243.
4. Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes. Cancer Res 1986; 46: 5276-5281.
5. Uchibori R, Okada T, Ito T, Urabe M, Mizukami H, Kume A, Ozawa K. Retroviral vector-producting mesenchymal stem cells for targeted suicide cancer gene therapy. Gene Med 2009; 11: 373-81.
6. Henschler R, Deak E, Seifried E. Homing of mesenchymal stem cells. Transfus Med Hemother 2008; 35: 306-312.
7. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860-867.
8. Kanehira M, Xin H, Hoshino K, Maemondo M, Mizuguchi H, Hayakawa T, Matsumoto K, Nakamura T, Nukiwa T, Saijo Y. Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells. Cancer Gene Ther 2007; 14: 894-903.
9. Nakamura K, Ito Y, Kawano Y, Kurozumi K, Kobune M, Tsuda H, Bizen A, Honmou O, Niitsu Y, Hamada H. Antitumor effect of genetically engineered mesenchymal stem cells in a rat glicm a model. Gene Ther 2004; 11: 1155-1164.
10. Ren C, Kumar S, Chanda D. Cancer gene therapy using mesenchymal stem cells expressing interferon-beta in a mouse prostate cancer lung metastasis model. Gene Ther 2008; 15: 1446-1453.
11. Stoff-Khalili MA, Rivera AA, Mathis JM, Banerjee NS, Moon AS, Hess A, Rocconi RP, Numnum TM, Everts M, Chow LT, Douglas JT, Siegal GP, Zhu ZB, Bender HG, Dall P, Stoff A, Pereboeva L, Curiel DT. Mesenchymal stem cells as a vehicle for targeted delicery of CRAds to lung metastases of breast carcinoma. Breast Cancer Treat 2007; 105: 157-167.
12. Hasenburg A, Tong XW, Rojas-Martinez A, Nyberg-Hoffman C, Kieback CC, Kaplan A, Kaufman RH, Ramzy I, Aguilar-Cordova E, Kieback DG. Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer. Cancer Gene Ther 2000; 7: 839-844.
13. Ayala G, Wheeler TM, Shalev M, Thompson TC, Miles B, Aguilar-Cordova E, Chakraborty S, Kadmon D. Cytopathic effect of in situ gene therapy in prostate cancer. Hum Pathol 2000; 31: 866-870.
14. Shalev M, Kadmon D, Teh BS, Butler EB, Aguilar-Cordova E, Thompson TC, Herman JR, Adler HL, Scardino PT, Miles BJ. Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer. J Urol 2000; 163: 1747-1750.
15. Zhang G, Gurtu V, Kain SR. An enhanced green fluorescent protein allows sensitive detection of gene transfer in mammalian cells. Biochem Biophys Res Commun 1996; 227: 707-711.
16. Cormack BP, Valdivia RH, Falkow S. FACS-optimized mutants of the green fluorescent protein (GFP). Gene 1996; 173: 33-38.
17. Taylor JI, Hurst CD, Davies MJ, Sachsinger N, Bruce IJ. Application of magnetite and silica-magnetite composites to the isolation of genomic DNA. J Chromatogr A 2000; 890: 159-166.
18. Nakazawa K, Kalassy M, Sahuc F, Collombel C, Damour O. Pigmented human skin equivalent-as a model of the mechanisms of control of cell-cell and cell-matrix interactions. Med Bio Eng Comput 1998; 36: 813-820.
19. Alavi A, Stupack DG. Cell survival in a three-dimensional matrix. Methods Enzymol 2007; 426: 85-101.
20. Woodward TL, Xie J, Fendrick JL, Haslam SZ. Proliferation of mouse mammary epithelial cells in vitro: Interactions among epidermal growth factor, insulin-like growth factor I, ovarian hormones, and extracellular matrix proteins. Endocrinology 2000; 141: 3578-3586.
21. Chen Y, Wei T, Yan L, Lawrence F, Qian HR, Burkholder TP, Starling JJ, Yingling JM, Shou J. Developing and applying a gene functional association network for anti-angiogenic co-culture model. BMC Genomics 2008; 9: 264.
22. Sorrell JM, Baber MA, Caplan AI. A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells. Cells Tissues Organs 2007; 186: 157-68.
23. Li X, Yu X, Lin Q, Deng C, Shan Z, Yang M, Lin S. Bone marrow mesenchymal stem cells differentiate into functional cardiac phenotypes by cardiac microenvironment. J Mol Cell Cardiol 2006; 54: 3254-3266.
24. Cheng L, Hammond H, Ye Z, Zhan X, Dravid G. Human adult marrow cells support prolonged expansion of human embryonic stem cells in culture. Stem Cells 2003; 21: 131-42.