Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Jones, Kevin S ^a,b   Corbin, Joshua G ^b   Huntsman, Molly M ^c,d  

^a HOWARD UNIVERSITY   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d University of Colorado Denver and Children s Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POTASSIUM CHANNEL KV1.1; AMINO ACID RECEPTOR BLOCKING AGENT; BACTERIAL PROTEIN; DIZOCILPINE MALEATE; GLUTAMIC ACID; NR2B NMDA RECEPTOR; PARVALBUMIN; PHOTOPROTEIN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL FUNCTION; CONTROLLED STUDY; DISEASE MODEL; FAST SPIKING INTERNEURON; FIRST SPIKE LATENCY; GLUTAMATERGIC SYNAPSE; INTERNEURON; LATENT PERIOD; MALE; MOUSE; NEOCORTEX; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PERINATAL DEVELOPMENT; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SCHIZOPHRENIA; SYNAPSE; ACTION POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; REPORTER GENE; SIGNAL TRANSDUCTION; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; GENES, REPORTER; GLUTAMIC ACID; INJECTIONS, SUBCUTANEOUS; INTERNEURONS; KV1.1 POTASSIUM CHANNEL; LUMINESCENT PROTEINS; MICE; MICE, TRANSGENIC; NEOCORTEX; PARVALBUMINS; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 84907782388     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109303     Document Type: Article

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