Decreased infarct volume and intracranial hemorrhage associated with intra-arterial nonionic iso-osmolar contrast material in an MCA occlusion/reperfusion model

American Journal of Neuroradiology

Volumn 35, Issue 10, 2014, Pages 1885-1891

  Morales, H ^a   Lu, A ^b   Kurosawa, Y ^b   Clark, J F ^b   Leach, J ^a   Weiss, K ^c   Tomsick, T ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IODIXANOL; IOPAMIDOL; SODIUM CHLORIDE; CONTRAST MEDIUM; IODOBENZOIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTIFACT; BASAL GANGLION; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN PERFUSION; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFUSION WEIGHTED IMAGING; EXPERIMENTAL STUDY; HYPERTHERMIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; RAT; ANIMAL; BRAIN INFARCTION; CEREBROVASCULAR ACCIDENT; COMPLICATION; DISEASE MODEL; INTRAARTERIAL DRUG ADMINISTRATION; PATHOLOGY; REPERFUSION;

ANIMALS; CEREBRAL HEMORRHAGE; CEREBRAL INFARCTION; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; INFUSIONS, INTRA-ARTERIAL; IOPAMIDOL; MALE; RATS; REPERFUSION; STROKE; TRIIODOBENZOIC ACIDS;

EID: 84907764263     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A3953     Document Type: Conference Paper

References (50)

1. Hom J, Dankbaar JW, Soares BP, et al. Blood-brain barrier permeability assessed by perfusion CT predicts symptomatic hemorrhagic transformation and malignant edema in acute ischemic stroke. AJNR Am J Neuroradiol 2011;32:41-48
2. Aviv RI, d'Esterre CD, Murphy BD, et al. Hemorrhagic transformation of ischemic stroke: prediction with CT perfusion. Radiology 2009;250:867-77
3. Lin K, Kazmi KS, Law M, et al. Measuring elevated microvascular permeability and predicting hemorrhagic transformation in acute ischemic stroke using first-pass dynamic perfusion CT imaging. AJNR Am J Neuroradiol 2007;28:1292-98
4. Lummel N, Schulte-Altedorneburg G, Bernau C, et al. hyperattenuated intracerebral lesions after mechanical recanalization in acute stroke. AJNR Am J Neuroradiol 2014;35:345-51
5. Kurosawa Y, Lu A, Khatri P, et al. Intra-arterial iodinated radiographic contrast material injection administration in a rat middle cerebral artery occlusion and reperfusion model: possible effects on intracerebral hemorrhage. Stroke 2010;41:1013-17
6. Koizumi A, Yoshida Y, Nakazawa T, et al. Experimental studies of ischemic brain edema: a new experimental model of cerebral em-bolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 1986;8:1-8
7. Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20:84-91
8. Nestler U, Seifner S, Greschus S, et al. Doppler ultrasonographic measurement of blood flow velocities in major cerebral arteries of the rat using triplex mode. Neurol Res 2006;28:877-80
9. Zhang RL, Chopp M, Zhang ZG, et al. A rat model of focal embolic cerebral ischemia. Brain Res 1997;766:83-92
10. Lapchak PA, Chapman DF, Zivin JA. Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. Stroke 2000;31:3034-40
11. Lapchak PA, Araujo DM, Song D, et al. The nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced intracerebral hemorrhage after thromboembolic stroke. Stroke 2002;33:147-52
12. Lu A, Clark JF, Broderick JP, et al. Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain. Exp Neurol 2009;216:407-12
13. Edvinsson L, MacKenzie ET, McCulloch J. General and comparative anatomy of the cerebral circulation. In: Edvinsson L, MacKenzie ET, McCulloch J. Cerebral Blood Flow and Metabolism. New York: Raven Press; 1993:3-39
14. Aulie Michelet A. Effects of intravascular contrast media on bloodbrain barrier: comparison between iothalamate, iohexol, iopentol and iodixanol. Acta Radiol 1987;28:329-33
15. Sage MR, Wilson AJ, Scroop R. Contrast media and the brain: the basis ofCTandMRimaging enhancement. Neuroimaging ClinNAm 1998;8:695-707
16. Sage MR, Wilcox J, Evill CA, et al. Comparison of blood-brain barrier disruption by intracarotid iopamidol and methylglucamine iothalamate. AJNR Am J Neuroradiol 1983;4:893-95
17. Hayakawa K, Morris TM, Katzberg RW. Opening of the blood-brain barrier by intravenous contrast media in euvolemic and dehydrated rabbits. Acta Radiol 1989;30:439-44
18. Doerfler A, Engelhorn T, von Kummer R, et al. Are iodinated contrast agents detrimental in acute cerebral ischemia? An experimental study in rats. Radiology 1998;206:211-17
19. Pannu N, Wiebe N, Tonelli M. Prophylaxis strategies for contrastinduced nephropathy. JAMA 2006;295:2765-79
20. Fountaine H, Harnish P, Andrew E, et al. Safety, tolerance, and pharmacokinetics of iodixanol injection, a nonionic, isosmolar, hexaiodinated contrast agent. Acad Radiol 1996(3 suppl 3):S475-84
21. Finley Caulfield A, Wijman CA. Management of acute ischemic stroke. Neurol Clin 2008;26:345-71, vii
22. Diringer MN, Zazulia AR. Osmotic therapy: fact and fiction. Neurocrit Care 2004;1:219-33
23. Qureshi AI, Wilson DA, Traystman RJ. Treatment of elevated intracranial pressure in experimental intracerebral hemorrhage: comparison between mannitol and hypertonic saline. Neurosurgery 1999;44:1055-63, discussion 1063-64
24. Franke RP, Fuhrmann R, Hiebl B, et al. Influence of various radiographic contrast media on the buckling of endothelial cells. Microvasc Res 2008;76:110-13
25. Wilcox J, Wilson AJ, Evill CA, et al. A comparison of blood-brain barrier disruption by intracarotid iohexol and iodixanol in the rabbit. AJNR Am J Neuroradiol 1987;8:769-72
26. Macdougall NJ, McVerry F, Baird S, et al. Iodinated contrast media and cerebral hemorrhage after intravenous thrombolysis. Stroke 2011;42:2170-74
27. Khatri P, Broderick JP, Khoury JC, et al. Microcatheter contrast injections during intra-arterial thrombolysis may increase intracranial hemorrhage risk. Stroke 2008;39:3283-87
28. Leong S, Fanning NF. Persistent neurological deficit from iodinated contrast encephalopathy following intracranial aneurysm coiling: a case report and review of the literature. Interv Neuroradiol 2012;18:33-41
29. Hayman LA, Evans RA, Bastion FO, et al. Delayed high dose contrast CT: identifying patients at risk of massive hemorrhagic infarction. AJR Am J Roentgenol 1981;136:1151-59
30. Heinrich MC, Kuhlmann MK, Grgic A, et al. Cytotoxic effects of ionic high-osmolar, nonionic monomeric, and nonionic iso-osmolar dimeric iodinated contrast media on renal tubular cells in vitro. Radiology 2005;235:843-49
31. McClennan BL, Stolberg HO. Intravascular contrast media: ionic versus nonionic-current status. Radiol Clin North Am 1991; 29:437-54
32. Dooley M, Jarvis B. Iomeprol: a review of its use as a contrast medium. Drugs 2000;59:1169-86
33. Sood R, Taheri S, Estrada EY, et al. Quantitative evaluation of the effect of propylene glycol on BBB permeability. J Magn Reson Imaging 2007;25:39-47
34. Jacobsen PB, Larsen A, Konarboland R, et al. Biotransformation of nonionic x-ray contrast agents in vivo and in vitro. Drug Metab Dispos 1999;27:1205-13
35. Spencer CM, Goa KL. Iodixanol: a review of its pharmacodynamic and pharmacokinetic properties and diagnostic use as an x-ray contrast medium. Drugs 1996;52:899-927
36. Aspelin P, Stacul F, Thomsen HS, et al. Effects of iodinated contrast media on blood and endothelium. Eur Radiol 2006;16:1041-49
37. Georgakis A, Ener RA, Jin J, et al. Risk of thrombogenicity among nonionic radiocontrast agents. J Invasive Cardiol 2008;20: 349-53
38. Kim SJ, Salem MR, Joseph NJ, et al. Contrast media adversely affect oxyhemoglobin dissociation. Anesth Analg 1990;71:73-76
39. Wilcox J, Sage MR. Is viscosity important in the production of blood-brain barrier disruption by intracarotid contrast media? Neuroradiology 1984;26:511-13
40. Dirnagl U, Lindauer U,ThemA, et al. Global cerebral ischemia in the rat: online monitoring of oxygen free radical production using chemiluminescence in vivo. J Cereb Blood Flow Metab 1995;15:929-40
41. Kumura E, Yoshimine T, Iwatsuki KI, et al. Generation of nitric oxide and superoxide during reperfusion after focal cerebral ischemia in rats. Am J Physiol 1996;270:C748-52
42. Rosell A, Foerch C, Murata Y, et al. Mechanisms and markers for hemorrhagic transformation after stroke. Acta Neurochir Suppl 2008;105:173-78
43. Lu A, Clark JF, Broderick JP, et al. Reperfusion activates metalloproteinases that contribute to neurovascular injury. Exp Neurol 2008;210:549-59
44. Zador Z, Stiver S, Wang V, et al. Role of aquaporin-4 in cerebral edema and stroke. Handb Exp Pharmacol 2009:159-70
45. Simard JM, Kent TA, Chen M, et al. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol 2007;6:258-68
46. Kim EY, Na DG, Kim SS, et al. Prediction of hemorrhagic transformation in acute ischemic stroke: role of diffusion-weighted imaging and early parenchymal enhancement. AJNR Am J Neuroradiol 2005;26:1050-55
47. Tong DC, Adami A, Moseley ME, et al. Prediction of hemorrhagic transformation following acute stroke: role of diffusion-and perfusion-weighted magnetic resonance imaging. Arch Neurol 2001;58:587-93
48. Hoehn-Berlage M, Norris DG, Kohno K, et al. Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances.J Cereb Blood Flow Metab 1995;15:1002-11
49. Knight RA, Barker PB, Fagan SC, et al. Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke 1998;29:144-51
50. Reglodi D, Somogyvari-Vigh A, Maderdrut JL, et al. Postischemic spontaneous hyperthermia and its effects in middle cerebral artery occlusion in the rat. Exp Neurol 2000;163:399-407