First human use of a radiopharmaceutical prepared by continuous-flow microfluidic radiofluorination: Proof of concept with the tau imaging agent [18F]T807

Molecular Imaging

Volumn 13, Issue 8, 2014, Pages

  Liang, Steven H ^a   Yokell, Daniel L ^a   Normandin, Marc D ^a   Rice, Peter A ^a   Jackson, Raul N ^a   Shoup, Timothy M ^a   Brady, Thomas J ^a   El Fakhri, Georges ^a   Collier, Thomas L ^a   Vasdev, Neil ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL RESEARCH; FLUORINE COMPOUNDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PURIFICATION;

HIGH SPECIFIC ACTIVITIES; MICRO-FLUIDIC DEVICES; MICROFLUIDIC FLOW; POSITRON EMISSION; PRECLINICAL IMAGING; RADIOCHEMICAL PURITY; RADIOCHEMICAL YIELD; RADIOFLUORINATION;

MICROFLUIDICS;

7-(6-FLUOROPYRIDIN-3-YL)-5H-PYRIDO(4,3-B)INDOLE; CARBOLINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ADULT; BRAIN; DEVICES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MICROFLUIDICS; POSITRON EMISSION TOMOGRAPHY; PROCEDURES; SCINTISCANNING; SYNTHESIS;

ADULT; BRAIN; CARBOLINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MALE; MICROFLUIDICS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 84907701516     PISSN: 15353508     EISSN: 15360121     Source Type: Journal    
DOI: 10.2310/7290.2014.00025     Document Type: Article

References (16)

1. 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor. Lab Chip 2004;4:523-5, doi:10.1039/b407938h.
2. Lee C-C, Sui G, Elizarov A. et al. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science 2005;310:1793-6, doi:10.1126/science.1118919.
3. 13N-labelled radiotracers by using microfluidic technology. J Label Compd Radiopharm 2012;55:332-8, doi:10.1002/jlcr.2946.
4. Pascali G, Watts P, Salvadori PA. Microfluidics in radiopharmaceutical chemistry. Nucl Med Biol 2013;40:776-87, doi:10.1016/j.nucmedbio.2013.04.004.
5. Rensch C, Jackson A, Lindner S. et al. Microfluidics: a groundbreaking technology for PET tracer production? Molecules 2013;18:7930-56, doi:10.3390/molecules18077930.
6. Lebedev A, Miraghaie R, Kotta K. et al. Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer. Lab Chip 2013;13:136-45, doi:10.1039/c2lc40853h.
7. 18F-labeled compounds. Chem Commun 2013;49:8755-7, doi:10.1039/c3cc45166f.
8. Pascali G, Mazzone G, Saccomanni G. et al. Microfluidic approach for fast labeling optimization and dose-on-demand implementation. Nucl Med Biol 2010;37:547-55, doi:10.1016/j.nucmedbio.2010.03.006.
9. 18F-fluorocholine derivatives through a two-step microfluidic approach. Nucl Med Biol 2011;38:637-44, doi:10.1016/j.nucmedbio.2011.01.005.
10. Arima V, Pascali G, Lade O. et al. Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab Chip 2013;13:2328-36, doi:10.1039/c3lc00055a.
11. Pascali G, Berton A, DeSimone M. et al. Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis. Appl Radiat Isot 2014;84:40-7, doi:10.1016/j.apradiso.2013.10.020.
12. 18F]FPEB suitable for human PET imaging. Med Chem Commun 2014;5:432-5, doi:10.1039/c3md00335c.
13. 18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement 2013;9:666-76, doi:10.1016/j.jalz.2012.11.008.
14. Chien DT, Bahri SS, Szardenings AK. et al. Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807. J Alzheimers Dis 2013;34:457-68, doi:10.3233/JAD-122059.
15. 18F]T807. J Label Compd Radiopharm 2013;56:736-40, doi:10.1002/jlcr.3098.
16. 18F]fluoride ion with diaryliodonium salts. J Org Chem 2010;75:3332-8, doi:10.1021/jo100361d.