Peroxisome-localized hepatitis Bx protein increases the invasion property of hepatocellular carcinoma cells

Archives of Virology

Volumn 159, Issue 10, 2014, Pages 2549-2557

  Han, Jae Min ^a   Kang, Jung Ah ^a   Han, Min Hee ^a   Chung, Kyung Hun ^a   Lee, Cho Rong ^a   Song, Woo Keun ^a   Jun, Youngsoo ^a   Park, Sung Gyoo ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; GELATINASE B; HEPATITIS B VIRUS X PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MATRILYSIN; MESSENGER RNA; MMP1 PROTEIN, HUMAN; MMP7 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; TRANSACTIVATOR PROTEIN;

BIOSYNTHESIS; CELL TRANSFORMATION; DISEASE COURSE; GENETICS; HEK293 CELL LINE; HEPATITIS B; HEPATITIS B VIRUS; HEPG2 CELL LINE; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOGENICITY; PATHOLOGY; PEROXISOME; TUMOR CELL LINE; TUMOR INVASION; VIROLOGY;

CADHERINS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; HEK293 CELLS; HEP G2 CELLS; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEOPLASM INVASIVENESS; NF-KAPPA B; PEROXISOMES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 84907693680     PISSN: 03048608     EISSN: 14328798     Source Type: Journal    
DOI: 10.1007/s00705-014-2105-4     Document Type: Article

References (24)

1. Baes M, Gressens P, Baumgart E, Carmeliet P, Casteels M, Fransen M, Evrard P, Fahimi D, Declercq PE, Collen D, van Veldhoven PP, Mannaerts GP (1997) A mouse model for Zellweger syndrome. Nat Genet 17:49–57
2. Chung TW, Lee YC, Kim CH (2004) Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J 18:1123–1125
3. Clippinger AJ, Bouchard MJ (2008) Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. J Virol 82:6798–6811
4. Delille HK, Alves R, Schrader M (2009) Biogenesis of peroxisomes and mitochondria: linked by division. Histochem Cell Biol 131:441–446
5. Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141:668–681
6. Jeong SP, Kang JA, Park SG (2012) Intestinal intraepithelial TCRgammadelta(+) T cells are activated by normal commensal bacteria. J Microbiol 50:837–841
7. Kim CM, Koike K, Saito I, Miyamura T, Jay G (1991) HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351:317–320
8. Kim SY, Lee PY, Shin HJ, Kim do H, Kang S, Moon HB, Kang SW, Kim JM, Park SG, Park BC, Yu DY, Bae KH, Lee SC (2009) Proteomic analysis of liver tissue from HBx-transgenic mice at early stages of hepatocarcinogenesis. Proteomics 9:5056–5066
9. Kumar M, Jung SY, Hodgson AJ, Madden CR, Qin J, Slagle BL (2011) Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon. J Virol 85:987–995
10. Lim SO, Gu JM, Kim, Kim HS, Park YN, Park CK, Cho JW, Park YM, Jung G (2008) Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology 135:2128–2140 (2140 e2121–2128)
11. Liu LP, Liang HF, Chen XP, Zhang WG, Yang SL, Xu T, Ren L (2010) The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs. Cancer Investig 28:443–451
12. Liu Y, Tong Z, Li T, Chen Q, Zhuo L, Li W, Wu RC, Yu C (2012) Hepatitis B virus X protein stabilizes amplified in breast cancer 1 protein and cooperates with it to promote human hepatocellular carcinoma cell invasiveness. Hepatology 56:1015–1024
13. Liu YN, Lee WW, Wang CY, Chao TH, Chen Y, Chen JH (2005) Regulatory mechanisms controlling human E-cadherin gene expression. Oncogene 24:8277–8290
14. Ma J, Sun T, Park S, Shen G, Liu J (2011) The role of hepatitis B virus X protein is related to its differential intracellular localization. Acta biochimica et biophysica Sinica 43:583–588
15. Morgan MJ, Liu ZG (2011) Crosstalk of reactive oxygen species and NF-kappaB signaling. Cell Res 21:103–115
16. Ng SA, Lee C (2011) Hepatitis B virus X gene and hepatocarcinogenesis. J Gastroenterol 46:974–990
17. Park SG, Ryu HM, Lim SO, Kim YI, Hwang SB, Jung G (2005) Interferon-gamma inhibits hepatitis B virus-induced NF-kappaB activation through nuclear localization of NF-kappaB-inducing kinase. Gastroenterology 128:2042–2053
18. Park SG, Chung C, Kang H, Kim JY, Jung G (2006) Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter. J Biol Chem 281:31770–31777
19. Schrader M, Fahimi HD (2004) Mammalian peroxisomes and reactive oxygen species. Histochem Cell Biol 122:383–393
20. Schrader M, Fahimi HD (2006) Peroxisomes and oxidative stress. Biochimica et biophysica acta 1763:1755–1766
21. Tang H, Oishi N, Kaneko S, Murakami S (2006) Molecular functions and biological roles of hepatitis B virus x protein. Cancer Sci 97:977–983
22. Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8:579–591
23. Wanders RJ, Waterham HR (2006) Biochemistry of mammalian peroxisomes revisited. Annu Rev Biochem 75:295–332
24. Waris G, Huh KW, Siddiqui A (2001) Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cellular Biol 21:7721–7730