Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria

PLoS Genetics

Volumn 10, Issue 9, 2014, Pages

  Akabane, Shiori ^a   Ueda, Takuya ^a   Nierhaus, Knud H ^b   Takeuchi, Nono ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMATURE COLON CARCINOMA TRANSCRIPT 1 PROTEIN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; TRANSFER RNA; UNCLASSIFIED DRUG; CODON; ICT1 PROTEIN, HUMAN; PROTEIN; PROTEIN BINDING; STOP CODON;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; GENE INSERTION; GENE INSERTION SEQUENCE; HUMAN; HUMAN CELL; MITOCHONDRION; MUTATIONAL ANALYSIS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; POLYSOME; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SECRETION; PROTEIN SYNTHESIS; RIBOSOME; STOICHIOMETRY; STOP CODON; TRANSCRIPTION TERMINATION; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CODON; DRUG EFFECTS; GENETICS; LIVER MITOCHONDRION; METABOLISM; MOLECULAR GENETICS; PIG; RNA TRANSLATION; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; CODON; CODON, TERMINATOR; HUMANS; MITOCHONDRIA; MITOCHONDRIA, LIVER; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEINS; RIBOSOMES; RNA, MESSENGER; SEQUENCE ALIGNMENT; SWINE;

EID: 84907587253     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004616     Document Type: Article

References (26)

1. Neubauer C, Gillet R, Kelley AC, Ramakrishnan V, (2012) Decoding in the absence of a codon by tmRNA and SmpB in the ribosome. Science 335: 1366–1369.
2. Chadani Y, Ito K, Kutsukake K, Abo T, (2012) ArfA recruits release factor 2 to rescue stalled ribosomes by peptidyl-tRNA hydrolysis in Escherichia coli. Mol Microbiol 86: 37–50.
3. Shimizu Y, (2012) ArfA recruits RF2 into stalled ribosomes. J Mol Biol 423: 624–631.
4. Handa Y, Inaho N, Nameki N, (2011) YaeJ is a novel ribosome-associated protein in Escherichia coli that can hydrolyze peptidyl-tRNA on stalled ribosomes. Nucleic Acids Res 39: 1739–1748.
5. Gagnon MG, Seetharaman SV, Bulkley D, Steitz TA, (2012) Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome. Science 335: 1370–1372.
6. Duarte I, Nabuurs SB, Magno R, Huynen M, (2012) Evolution and diversification of the organellar release factor family. Mol Biol Evol 29: 3497–3512.
7. Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, et al. (2010) A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. EMBO J 29: 1116–1125.
8. Koc EC, Cimen H, Kumcuoglu B, Abu N, Akpinar G, et al. (2013) Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. Front Physiol 4: 183.
9. Nozaki Y, Matsunaga N, Ishizawa T, Ueda T, Takeuchi N, (2008) HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG. Genes Cells 13: 429–438.
10. Soleimanpour-Lichaei HR, Kuhl I, Gaisne M, Passos JF, Wydro M, et al. (2007) mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. Mol Cell 27: 745–757.
11. Shimizu Y, Inoue A, Tomari Y, Suzuki T, Yokogawa T, et al. (2001) Cell-free translation reconstituted with purified components. Nat Biotechnol 19: 751–755.
12. Nissen P, Hansen J, Ban N, Moore PB, Steitz TA, (2000) The structural basis of ribosome activity in peptide bond synthesis. Science 289: 920–930.
13. Lind C, Sund J, Aqvist J, (2013) Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons. Nat Commun 4: 2940.
14. Korostelev A, Asahara H, Lancaster L, Laurberg M, Hirschi A, et al. (2008) Crystal structure of a translation termination complex formed with release factor RF2. Proc Natl Acad Sci USA 105: 19684–19689.
15. Laurberg M, Asahara H, Korostelev A, Zhu J, Trakhanov S, et al. (2008) Structural basis for translation termination on the 70S ribosome. Nature 454: 852–857.
16. Greber BJ, Boehringer D, Leitner A, Bieri P, Voigts-Hoffmann F, et al. (2014) Architecture of the large subunit of the mammalian mitochondrial ribosome. Nature 505: 515–519.
17. Ott M, Herrmann JM, (2010) Co-translational membrane insertion of mitochondrially encoded proteins. Biochim Biophys Acta 1803: 767–775.
18. Dujeancourt L, Richter R, Chrzanowska-Lightowlers ZM, Bonnefoy N, Herbert CJ, (2013) Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria. Mitochondrion 13: 871–880.
19. Temperley R, Richter R, Dennerlein S, Lightowlers RN, Chrzanowska-Lightowlers ZM, (2010) Hungry codons promote frameshifting in human mitochondrial ribosomes. Science 327: 301.
20. Kogure H, Handa Y, Nagata M, Kanai N, Guntert P, et al. (2013) Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ. Nucleic Acids Res 42: 3152–63 doi:10.1093/nar/gkt1280
21. Huynen MA, Duarte I, Chrzanowska-Lightowlers ZM, Nabuurs SB, (2012) Structure based hypothesis of a mitochondrial ribosome rescue mechanism. Biol Direct 7: 14.
22. Spremulli LL, (2007) Large-scale isolation of mitochondrial ribosomes from mammalian tissues. Methods Mol Biol 372: 265–275.
23. Triana-Alonso FJ, Chakraburtty K, Nierhaus KH, (1995) The elongation factor 3 unique in higher fungi and essential for protein biosynthesis is an E site factor. J Biol Chem 270: 20473–20478.
24. Triana F, Nierhaus KH, Chakraburtty K, (1994) Transfer RNA binding to 80S ribosomes from yeast: evidence for three sites. Biochem. Mol Biol Int 33: 909–915.
25. Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, et al. (2009) EF-G2mt Is an Exclusive Recycling Factor in Mammalian Mitochondrial Protein Synthesis. Mol Cell 35: 502–510.
26. Handa Y, Hikawa Y, Tochio N, Kogure H, Inoue M, et al. (2010) Solution structure of the catalytic domain of the mitochondrial protein ICT1 that is essential for cell vitality. J Mol Biol 404: 260–273.