The Role of Iron in Prion Disease and Other Neurodegenerative Diseases

PLoS Pathogens

Volumn 10, Issue 9, 2014, Pages

  Singh, Neena ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON;

ALZHEIMER DISEASE; ARTICLE; BRAIN IRON DYSHOMEOSTASIS; CREUTZFELDT JAKOB DISEASE; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; HOMEOSTASIS AND REGULATION; IRON METABOLISM; IRON TRANSPORT; NERVE DEGENERATION; PARKINSON DISEASE; PATHOGENESIS; PRION DISEASE; ANIMAL; HUMAN; METABOLISM; PATHOLOGY;

ANIMALS; HUMANS; IRON; NEURODEGENERATIVE DISEASES; PRION DISEASES;

EID: 84907573446     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004335     Document Type: Article

References (20)

1. Singh N, Haldar S, Tripathi AK, Horback K, Wong J, et al. (2014) Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities. Antioxid Redox Signal 20: 1324–1363.
2. Haldar S, Beveridge J, Wong J, Singh A, Galimberti D, et al. (2013) A low-molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD. Antioxid Redox Signal 19: 1662–1675.
3. Olivieri S, Conti A, Iannaccone S, Cannistraci CV, Campanella A, et al. (2011) Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention. J Neurosci 31: 18568–18577.
4. Singh A, Isaac AO, Luo X, Mohan ML, Cohen ML, et al. (2009) Abnormal brain iron homeostasis in human and animal prion disorders. PLoS Pathog 5: e1000336.
5. Greenough MA, Camakaris J, Bush AI, (2013) Metal dyshomeostasis and oxidative stress in Alzheimer's disease. Neurochem Int 62: 540–555.
6. Andersen HH, Johnsen KB, Moos T, (2014) Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration. Cell Mol Life Sci 71: 1607–1622.
7. Singh A, Haldar S, Horback K, Tom C, Zhou L, et al. (2013) Prion protein regulates iron transport by functioning as a ferrireductase. J Alzheimers Dis 35: 541–552.
8. Ohgami RS, Campagna DR, McDonald A, Fleming MD, (2006) The Steap proteins are metalloreductases. Blood 108: 1388–1394.
9. Singh A, Qing L, Kong Q, Singh N, (2012) Change in the characteristics of ferritin induces iron imbalance in prion disease affected brains. Neurobiol Dis 45: 930–938.
10. Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, et al. (2009) A systems approach to prion disease. Mol Syst Biol 5: 252.
11. Kim BH, Jun YC, Jin JK, Kim JI, Kim NH, et al. (2007) Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice. Neurosci Lett 422: 158–163.
12. Huzarewich RL, Medina S, Robertson C, Parchaliuk D, Booth SA, (2011) Transcriptional modulation in a leukocyte-depleted splenic cell population during prion disease. J Toxicol Environ Health A 74: 1504–1520.
13. Fernaeus S, Halldin J, Bedecs K, Land T, (2005) Changed iron regulation in scrapie-infected neuroblastoma cells. Brain Res Mol Brain Res 133: 266–273.
14. Basu S, Mohan ML, Luo X, Kundu B, Kong Q, et al. (2007) Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis. Mol Biol Cell 18: 3302–3312.
15. Mishra RS, Basu S, Gu Y, Luo X, Zou WQ, et al. (2004) Protease-resistant human prion protein and ferritin are cotransported across Caco-2 epithelial cells: implications for species barrier in prion uptake from the intestine. J Neurosci 24: 11280–11290.
16. Singh A, Kong Q, Luo X, Petersen RB, Meyerson H, et al. (2009) Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport. PLoS ONE 4: e6115.
17. Pushie MJ, Pickering IJ, Martin GR, Tsutsui S, Jirik FR, et al. (2011) Prion protein expression level alters regional copper, iron and zinc content in the mouse brain. Metallomics 3: 206–214.
18. Bandyopadhyay S, Cahill C, Balleidier A, Huang C, Lahiri DK, et al. (2013) Novel 5′ untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease. PLoS ONE 8: e65978.
19. Wong BX, Duce JA, (2014) The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders. Front Pharmacol 5: 81.
20. Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, et al. (2008) Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A 105: 18578–18583.