Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia

Respiratory Research

Volumn 15, Issue 1, 2014, Pages

  Yin, Lu ^a   Zheng, Dahai ^a   Limmon, Gino V ^a   Leung, Nicola H N ^a   Xu, Shuoyu ^b   Rajapakse, Jagath C ^b   Yu, Hanry ^a,c,d,e,f   Chow, Vincent T K ^a,g   Chen, Jianzhu ^a,h  

^a SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f Massachusetts Institute of Technology Cambridge   (United States)

^g NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^h MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aged; Alveolar type I cell; Alveolar type II cell; Club cell; Imaging analysis; Influenza; Lung damage repair; Pro SPC positive bronchiolar epithelial cell

Indexed keywords

OSELTAMIVIR; ANTIVIRUS AGENT;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRONCHIOLE; CELL DAMAGE; CELL LOSS; CELL REGENERATION; CONTROLLED STUDY; DISEASE SEVERITY; EPITHELIUM CELL; FEMALE; IMAGE ANALYSIS; INFLUENZA; LUNG ALVEOLUS CELL TYPE 1; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG DISEASE; LUNG INJURY; LUNG PARENCHYMA; MORTALITY; MOUSE; NONHUMAN; VIRUS LOAD; VIRUS PNEUMONIA; AGE; ANIMAL; C57BL MOUSE; CELL PROLIFERATION; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; INFLUENZA A VIRUS (H1N1); LUNG ALVEOLUS; LUNG ALVEOLUS CELL; ORTHOMYXOVIRIDAE INFECTIONS; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; PNEUMONIA, VIRAL; REGENERATION; RISK FACTOR; TIME; VIROLOGY;

AGE FACTORS; AGING; ANIMALS; ANTIVIRAL AGENTS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; INFLUENZA A VIRUS, H1N1 SUBTYPE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; OSELTAMIVIR; PNEUMOCYTES; PNEUMONIA, VIRAL; PULMONARY ALVEOLI; REGENERATION; RISK FACTORS; TIME FACTORS; VIRAL LOAD;

EID: 84907570990     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-014-0116-z     Document Type: Article

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