Hydroxybenzothiophene ketones are efficient pre-mRNA splicing modulators due to dual inhibition of Dyrk1A and Clk1/4

ACS Medicinal Chemistry Letters

Volumn 5, Issue 9, 2014, Pages 963-967

  Schmitt, Christian ^a   Miralinaghi, Parisa ^a   Mariano, Marica ^a   Hartmann, Rolf W ^a,b   Engel, Matthias ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

alternative splicing modifiers; cdc2 like kinases; Dual kinase inhibitor; dual specificity tyrosine (Y) phosphorylation regulated kinases

Indexed keywords

CLK1 PROTEIN; CLK4 PROTEIN; DYRK1A PROTEIN; KETONE DERIVATIVE; MESSENGER RNA PRECURSOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; PROCESS OPTIMIZATION; RNA SPLICING;

EID: 84907553147     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500059y     Document Type: Article

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