메뉴 건너뛰기




Volumn 32, Issue 29, 2014, Pages 3284-3290

Risk of subsequent malignant neoplasms in long-term Hereditary retinoblastoma survivors after chemotherapy and radiotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; TRETAMINE;

EID: 84907546653     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2013.54.7844     Document Type: Article
Times cited : (103)

References (59)
  • 1
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AG Jr: Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68:820-823, 1971
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 2
    • 0018934064 scopus 로고
    • Incidence of retinoblastoma in the United States
    • Pendergrass TW, Davis S: Incidence of retinoblastoma in the United States. Arch Ophthalmol 98:1204-1210, 1980
    • (1980) Arch Ophthalmol , vol.98 , pp. 1204-1210
    • Pendergrass, T.W.1    Davis, S.2
  • 3
    • 58349113391 scopus 로고    scopus 로고
    • Survival with retinoblastoma in the USA: 1975-2004
    • Broaddus E, Topham A, Singh AD: Survival with retinoblastoma in the USA: 1975-2004. Br J Ophthalmol 93:24-27, 2009
    • (2009) Br J Ophthalmol , vol.93 , pp. 24-27
    • Broaddus, E.1    Topham, A.2    Singh, A.D.3
  • 4
    • 84860637907 scopus 로고    scopus 로고
    • Variation of second cancer risk by family history of retinoblastoma among long-term survivors
    • Kleinerman RA, Yu CL, Little MP, et al: Variation of second cancer risk by family history of retinoblastoma among long-term survivors. J Clin Oncol 30:950-957, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 950-957
    • Kleinerman, R.A.1    Yu, C.L.2    Little, M.P.3
  • 5
    • 17144398035 scopus 로고    scopus 로고
    • Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: An extended follow-up
    • Kleinerman RA, Tucker MA, Tarone RE, et al: Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: An extended follow-up. J Clin Oncol 23:2272-2279, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 2272-2279
    • Kleinerman, R.A.1    Tucker, M.A.2    Tarone, R.E.3
  • 6
    • 0027172571 scopus 로고
    • Mortality from second tumors among long-term survivors of retinoblastoma
    • Eng C, Li FP, Abramson DH, et al: Mortality from second tumors among long-term survivors of retinoblastoma. J Natl Cancer Inst 85:1121-1128, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1121-1128
    • Eng, C.1    Li, F.P.2    Abramson, D.H.3
  • 7
    • 0030848527 scopus 로고    scopus 로고
    • Cancer incidence after retinoblastoma: Radiation dose and sarcoma risk
    • Wong FL, Boice JD Jr, Abramson DH, et al: Cancer incidence after retinoblastoma: Radiation dose and sarcoma risk. JAMA 278:1262-1267, 1997
    • (1997) JAMA , vol.278 , pp. 1262-1267
    • Wong, F.L.1    Boice, J.D.2    Abramson, D.H.3
  • 8
  • 10
    • 33846942292 scopus 로고    scopus 로고
    • Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma
    • Kleinerman RA, Tucker MA, Abramson DH, et al: Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst 99:24-31, 2007
    • (2007) J Natl Cancer Inst , vol.99 , pp. 24-31
    • Kleinerman, R.A.1    Tucker, M.A.2    Abramson, D.H.3
  • 11
    • 0031917294 scopus 로고    scopus 로고
    • Second nonocular tumors in survivors of bilateral retinoblastoma: A possible age effect on radiation-related risk
    • discussion 579-580
    • Abramson DH, Frank CM: Second nonocular tumors in survivors of bilateral retinoblastoma: A possible age effect on radiation-related risk. Ophthalmology 105:573-579, 1998; discussion 579-580
    • (1998) Ophthalmology , vol.105 , pp. 573-579
    • Abramson, D.H.1    Frank, C.M.2
  • 12
    • 0034986542 scopus 로고    scopus 로고
    • Second primary tumors in hereditary retinoblastoma: A register-based study, 1945-1997-Is there an age effect on radiation-related risk?
    • Moll AC, Imhof SM, Schouten-Van Meeteren AY, et al: Second primary tumors in hereditary retinoblastoma: A register-based study, 1945-1997-Is there an age effect on radiation-related risk? Ophthalmology 108:1109-1114, 2001
    • (2001) Ophthalmology , vol.108 , pp. 1109-1114
    • Moll, A.C.1    Imhof, S.M.2    Schouten-Van Meeteren, A.Y.3
  • 13
    • 1542318327 scopus 로고    scopus 로고
    • Lifetime risks of common cancers among retinoblastoma survivors
    • Fletcher O, Easton D, Anderson K, et al: Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst 96:357-363, 2004
    • (2004) J Natl Cancer Inst , vol.96 , pp. 357-363
    • Fletcher, O.1    Easton, D.2    Anderson, K.3
  • 14
    • 58049202910 scopus 로고    scopus 로고
    • Risk of second malignancies in survivors of retinoblastoma: More than 40 years of follow-up
    • Marees T, Moll AC, Imhof SM, et al: Risk of second malignancies in survivors of retinoblastoma: More than 40 years of follow-up. J Natl Cancer Inst 100:1771-1779, 2008
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1771-1779
    • Marees, T.1    Moll, A.C.2    Imhof, S.M.3
  • 15
    • 0014645511 scopus 로고
    • The practical management of retinoblastoma
    • Ellsworth RM: The practical management of retinoblastoma. Trans Am Ophthalmol Soc 67:462-534, 1969
    • (1969) Trans Am Ophthalmol Soc , vol.67 , pp. 462-534
    • Ellsworth, R.M.1
  • 16
    • 13144269751 scopus 로고
    • The treatment of retinoblastoma by radiation and triethylene melamine
    • Reese AB, Hyman GA, Merriam GR Jr, et al: The treatment of retinoblastoma by radiation and triethylene melamine. Am J Ophthalmol 43:865-872, 1957
    • (1957) Am J Ophthalmol , vol.43 , pp. 865-872
    • Reese, A.B.1    Hyman, G.A.2    Merriam, G.R.3
  • 17
    • 84932418287 scopus 로고
    • Treatment of retinoblastoma by radiation and triethylenemelamine
    • Reese AB, Hyman GA, Merriam GR Jr, et al: Treatment of retinoblastoma by radiation and triethylenemelamine. AMA Arch Ophthalmol 53:505-513, 1954
    • (1954) AMA Arch Ophthalmol , vol.53 , pp. 505-513
    • Reese, A.B.1    Hyman, G.A.2    Merriam, G.R.3
  • 18
    • 0020962353 scopus 로고
    • Successful treatment of osteogenic sarcoma developing as a second cancer in childhood
    • Pillay R, Graham-Pole J, Novak L, et al: Successful treatment of osteogenic sarcoma developing as a second cancer in childhood. Am J Pediatr Hematol Oncol 5:103-105, 1983
    • (1983) Am J Pediatr Hematol Oncol , vol.5 , pp. 103-105
    • Pillay, R.1    Graham-Pole, J.2    Novak, L.3
  • 19
    • 0022623369 scopus 로고
    • Second primary neoplasms in patients with retinoblastoma
    • Draper GJ, Sanders BM, Kingston JE: Second primary neoplasms in patients with retinoblastoma. Br J Cancer 53:661-671, 1986
    • (1986) Br J Cancer , vol.53 , pp. 661-671
    • Draper, G.J.1    Sanders, B.M.2    Kingston, J.E.3
  • 20
    • 13344261408 scopus 로고    scopus 로고
    • Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer
    • Hawkins MM, Wilson LM, Burton HS, et al: Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst 88:270-278, 1996
    • (1996) J Natl Cancer Inst , vol.88 , pp. 270-278
    • Hawkins, M.M.1    Wilson, L.M.2    Burton, H.S.3
  • 21
    • 3843124553 scopus 로고    scopus 로고
    • Nonocular second primary tumors after retinoblastoma: Retrospective study of 111 patients treated by electron beam radiotherapy with or without TEM
    • Schlienger P, Campana F, Vilcoq JR, et al: Nonocular second primary tumors after retinoblastoma: Retrospective study of 111 patients treated by electron beam radiotherapy with or without TEM. Am J Clin Oncol 27:411-419, 2004
    • (2004) Am J Clin Oncol , vol.27 , pp. 411-419
    • Schlienger, P.1    Campana, F.2    Vilcoq, J.R.3
  • 22
    • 0026011115 scopus 로고
    • Bone sarcomas as second malignant neoplasms following childhood cancer
    • Newton WA Jr, Meadows AT, Shimada H, et al: Bone sarcomas as second malignant neoplasms following childhood cancer. Cancer 67:193-201, 1991
    • (1991) Cancer , vol.67 , pp. 193-201
    • Newton, W.A.1    Meadows, A.T.2    Shimada, H.3
  • 23
    • 0038011920 scopus 로고    scopus 로고
    • Treatment of intraocular retinoblastoma with vincristine and carboplatin
    • Rodriguez-Galindo C, Wilson MW, Haik BG, et al: Treatment of intraocular retinoblastoma with vincristine and carboplatin. J Clin Oncol 21:2019-2025, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 2019-2025
    • Rodriguez-Galindo, C.1    Wilson, M.W.2    Haik, B.G.3
  • 25
    • 79958762360 scopus 로고    scopus 로고
    • Periocular topotecan for intraocular retinoblastoma
    • Mallipatna AC, Dimaras H, Chan HS, et al: Periocular topotecan for intraocular retinoblastoma. Arch Ophthalmol 129:738-745, 2011
    • (2011) Arch Ophthalmol , vol.129 , pp. 738-745
    • Mallipatna, A.C.1    Dimaras, H.2    Chan, H.S.3
  • 27
    • 0036252251 scopus 로고    scopus 로고
    • Overview: Chemotherapy for retinoblastoma-An expanding area of clinical research
    • Schouten-Van Meeteren AY, Moll AC, Imhof SM, et al: Overview: Chemotherapy for retinoblastoma-An expanding area of clinical research. Med Pediatr Oncol 38:428-438, 2002
    • (2002) Med Pediatr Oncol , vol.38 , pp. 428-438
    • Schouten-Van Meeteren, A.Y.1    Moll, A.C.2    Imhof, S.M.3
  • 28
    • 34548319118 scopus 로고    scopus 로고
    • A study of soft tissue sarcomas after childhood cancer in Britain
    • Jenkinson HC, Winter DL, Marsden HB, et al: A study of soft tissue sarcomas after childhood cancer in Britain. Br J Cancer 97:695-699, 2007
    • (2007) Br J Cancer , vol.97 , pp. 695-699
    • Jenkinson, H.C.1    Winter, D.L.2    Marsden, H.B.3
  • 29
    • 0031862282 scopus 로고    scopus 로고
    • Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood
    • Le Vu B, de Vathaire F, Shamsaldin A, et al: Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood. Int J Cancer 77:370-377, 1998
    • (1998) Int J Cancer , vol.77 , pp. 370-377
    • Le Vu, B.1    De Vathaire, F.2    Shamsaldin, A.3
  • 30
    • 0023239053 scopus 로고
    • Bone sarcomas linked to radiotherapy and chemotherapy in children
    • Tucker MA, D'Angio GJ, Boice JD Jr, et al: Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 317:588-593, 1987
    • (1987) N Engl J Med , vol.317 , pp. 588-593
    • Tucker, M.A.1    D'Angio, G.J.2    Boice, J.D.3
  • 31
    • 64749089013 scopus 로고    scopus 로고
    • Cause-specific mortality in long-term survivors of retinoblastoma
    • Yu CL, Tucker MA, Abramson DH, et al: Cause-specific mortality in long-term survivors of retinoblastoma. J Natl Cancer Inst 101:581-591, 2009
    • (2009) J Natl Cancer Inst , vol.101 , pp. 581-591
    • Yu, C.L.1    Tucker, M.A.2    Abramson, D.H.3
  • 32
    • 15744362518 scopus 로고    scopus 로고
    • International Classification of Childhood Cancer, third edition
    • Steliarova-Foucher E, Stiller C, Lacour B, et al: International Classification of Childhood Cancer, third edition. Cancer 103:1457-1467, 2005
    • (2005) Cancer , vol.103 , pp. 1457-1467
    • Steliarova-Foucher, E.1    Stiller, C.2    Lacour, B.3
  • 33
  • 34
    • 0000120995 scopus 로고
    • A class of K-sample tests for comparing the cumulative incidence of a competing risk
    • Gray R: A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Statist 16:1141-1154, 1988
    • (1988) Ann Statist , vol.16 , pp. 1141-1154
    • Gray, R.1
  • 35
    • 2942605981 scopus 로고    scopus 로고
    • Outcome of second malignancies after retinoblastoma: A retrospective analysis of 25 patients treated at the Institut Curie
    • Aerts I, Pacquement H, Doz F, et al: Outcome of second malignancies after retinoblastoma: A retrospective analysis of 25 patients treated at the Institut Curie. Eur J Cancer 40:1522-1529, 2004
    • (2004) Eur J Cancer , vol.40 , pp. 1522-1529
    • Aerts, I.1    Pacquement, H.2    Doz, F.3
  • 36
    • 84861214968 scopus 로고    scopus 로고
    • Second malignant neoplasms following chemoreduction with carboplatin, etoposide, and vincristine in 245 patients with intraocular retinoblastoma
    • Turaka K, Shields CL, Meadows AT, et al: Second malignant neoplasms following chemoreduction with carboplatin, etoposide, and vincristine in 245 patients with intraocular retinoblastoma. Pediatr Blood Cancer 59:121-125, 2012
    • (2012) Pediatr Blood Cancer , vol.59 , pp. 121-125
    • Turaka, K.1    Shields, C.L.2    Meadows, A.T.3
  • 37
    • 34347342867 scopus 로고    scopus 로고
    • Secondary acute myelogenous leukemia in patients with retinoblastoma: Is chemotherapy a factor?
    • Gombos DS, Hungerford J, Abramson DH, et al: Secondary acute myelogenous leukemia in patients with retinoblastoma: Is chemotherapy a factor? Ophthalmology 114:1378-1383, 2007
    • (2007) Ophthalmology , vol.114 , pp. 1378-1383
    • Gombos, D.S.1    Hungerford, J.2    Abramson, D.H.3
  • 38
    • 84879690229 scopus 로고    scopus 로고
    • Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951-2004
    • MacCarthy A, Bayne AM, Brownbill PA, et al: Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951-2004. Br J Cancer 108:2455-2463, 2013
    • (2013) Br J Cancer , vol.108 , pp. 2455-2463
    • MacCarthy, A.1    Bayne, A.M.2    Brownbill, P.A.3
  • 40
    • 0028169369 scopus 로고
    • P53 alterations in uterine leiomyosarcomas versus leiomyomas
    • de Vos S, Wilczynski SP, Fleischhacker M, et al: p53 alterations in uterine leiomyosarcomas versus leiomyomas. Gynecol Oncol 54:205-208, 1994
    • (1994) Gynecol Oncol , vol.54 , pp. 205-208
    • De Vos, S.1    Wilczynski, S.P.2    Fleischhacker, M.3
  • 41
    • 0029981711 scopus 로고    scopus 로고
    • Tumor suppressor genes and related molecules in leiomyosarcoma
    • Dei Tos AP, Maestro R, Doglioni C, et al: Tumor suppressor genes and related molecules in leiomyosarcoma. Am J Pathol 148:1037-1045, 1996
    • (1996) Am J Pathol , vol.148 , pp. 1037-1045
    • Dei Tos, A.P.1    Maestro, R.2    Doglioni, C.3
  • 42
    • 33645769816 scopus 로고    scopus 로고
    • Altered patterns of RB expression define groups of soft tissue sarcoma patients with distinct biological and clinical behavior
    • Polsky D, Mastorides S, Kim D, et al: Altered patterns of RB expression define groups of soft tissue sarcoma patients with distinct biological and clinical behavior. Histol Histopathol 21:743-752, 2006
    • (2006) Histol Histopathol , vol.21 , pp. 743-752
    • Polsky, D.1    Mastorides, S.2    Kim, D.3
  • 43
    • 0032762958 scopus 로고    scopus 로고
    • Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma
    • Zhai YL, Nikaido T, Orii A, et al: Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma. Gynecol Oncol 75:453-459, 1999
    • (1999) Gynecol Oncol , vol.75 , pp. 453-459
    • Zhai, Y.L.1    Nikaido, T.2    Orii, A.3
  • 44
    • 0032234769 scopus 로고    scopus 로고
    • Analysis of chromosome copy number changes in leiomyosarcoma through molecular cytogenetic methods [in German]
    • Otaño-Joos M, Mechtersheimer G, Ohl S, et al: Analysis of chromosome copy number changes in leiomyosarcoma through molecular cytogenetic methods [in German]. Verh Dtsch Ges Pathol 82:207-209, 1998
    • (1998) Verh Dtsch Ges Pathol , vol.82 , pp. 207-209
    • Otaño-Joos, M.1    Mechtersheimer, G.2    Ohl, S.3
  • 46
    • 77950630063 scopus 로고    scopus 로고
    • Incidence and susceptibility to therapy-related myeloid neoplasms
    • Leone G, Fianchi L, Pagano L, et al: Incidence and susceptibility to therapy-related myeloid neoplasms. Chem Biol Interact 184:39-45, 2010
    • (2010) Chem Biol Interact , vol.184 , pp. 39-45
    • Leone, G.1    Fianchi, L.2    Pagano, L.3
  • 47
    • 79951867438 scopus 로고    scopus 로고
    • Second malignancy risks after non-Hodgkin's lymphoma and chronic lymphocytic leukemia: Differences by lymphoma subtype
    • Morton LM, Curtis RE, Linet MS, et al: Second malignancy risks after non-Hodgkin's lymphoma and chronic lymphocytic leukemia: Differences by lymphoma subtype. J Clin Oncol 28:4935-4944, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 4935-4944
    • Morton, L.M.1    Curtis, R.E.2    Linet, M.S.3
  • 48
    • 0037028736 scopus 로고    scopus 로고
    • Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease
    • Travis LB, Gospodarowicz M, Curtis RE, et al: Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease. J Natl Cancer Inst 94:182-192, 2002
    • (2002) J Natl Cancer Inst , vol.94 , pp. 182-192
    • Travis, L.B.1    Gospodarowicz, M.2    Curtis, R.E.3
  • 49
    • 84890369874 scopus 로고    scopus 로고
    • Stomach cancer risk after treatment for Hodgkin lymphoma
    • Morton LM, Dores GM, Curtis RE, et al: Stomach cancer risk after treatment for Hodgkin lymphoma. J Clin Oncol 31:3369-3377, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 3369-3377
    • Morton, L.M.1    Dores, G.M.2    Curtis, R.E.3
  • 50
    • 84864049067 scopus 로고    scopus 로고
    • Secondary colorectal carcinoma after childhood cancer
    • Nottage K, McFarlane J, Krasin MJ, et al: Secondary colorectal carcinoma after childhood cancer. J Clin Oncol 30:2552-2558, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 2552-2558
    • Nottage, K.1    McFarlane, J.2    Krasin, M.J.3
  • 51
    • 84865684309 scopus 로고    scopus 로고
    • Risk factors associated with secondary sarcomas in childhood cancer survivors: A report from the Childhood Cancer Survivor Study
    • Henderson TO, Rajaraman P, Stovall M, et al: Risk factors associated with secondary sarcomas in childhood cancer survivors: A report from the Childhood Cancer Survivor Study. Int J Radiat Oncol Biol Phys 84:224-230, 2012
    • (2012) Int J Radiat Oncol Biol Phys , vol.84 , pp. 224-230
    • Henderson, T.O.1    Rajaraman, P.2    Stovall, M.3
  • 52
    • 64049093382 scopus 로고    scopus 로고
    • A phase I study of periocular topotecan in children with intraocular retinoblastoma
    • Chantada GL, Fandino AC, Carcaboso AM, et al: A phase I study of periocular topotecan in children with intraocular retinoblastoma. Invest Ophthalmol Vis Sci 50:1492-1496, 2009
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1492-1496
    • Chantada, G.L.1    Fandino, A.C.2    Carcaboso, A.M.3
  • 53
    • 84891697836 scopus 로고    scopus 로고
    • The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: A report from the Childhood Cancer Survivor Study
    • Green DM, Nolan VG, Goodman PJ, et al: The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: A report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer 61:53-67, 2014
    • (2014) Pediatr Blood Cancer , vol.61 , pp. 53-67
    • Green, D.M.1    Nolan, V.G.2    Goodman, P.J.3
  • 54
    • 0026754256 scopus 로고
    • Patterns of risk of hereditary retinoblastoma and applications to genetic counselling
    • Draper GJ, Sanders BM, Brownbill PA, et al: Patterns of risk of hereditary retinoblastoma and applications to genetic counselling. Br J Cancer 66:211-219, 1992
    • (1992) Br J Cancer , vol.66 , pp. 211-219
    • Draper, G.J.1    Sanders, B.M.2    Brownbill, P.A.3
  • 56
    • 0018642114 scopus 로고
    • Genetics of retinoblastoma
    • Vogel F: Genetics of retinoblastoma. Hum Genet 52:1-54, 1979
    • (1979) Hum Genet , vol.52 , pp. 1-54
    • Vogel, F.1
  • 57
    • 10744228566 scopus 로고    scopus 로고
    • Comprehensive screening for constitutional RB1 mutations by DHPLC and QMPSF
    • Houdayer C, Gauthier-Villars M, Laugé A, et al: Comprehensive screening for constitutional RB1 mutations by DHPLC and QMPSF. Hum Mutat 23:193-202, 2004
    • (2004) Hum Mutat , vol.23 , pp. 193-202
    • Houdayer, C.1    Gauthier-Villars, M.2    Laugé, A.3
  • 58
    • 77954213386 scopus 로고    scopus 로고
    • Risk of third malignancies and death after a second malignancy in retinoblastoma survivors
    • Marees T, van Leeuwen FE, Schaapveld M, et al: Risk of third malignancies and death after a second malignancy in retinoblastoma survivors. Eur J Cancer 46:2052-2058, 2010
    • (2010) Eur J Cancer , vol.46 , pp. 2052-2058
    • Marees, T.1    Van Leeuwen, F.E.2    Schaapveld, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.