Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 53, Issue 10, 2014, Pages 1123-1129.e6

  Groen Blokhuis, Maria M ^a,b   Middeldorp, Christel M ^a,b   Kan, Kees Jan ^a   Abdellaoui, Abdel ^a   Van Beijsterveldt, Catharina E M ^a   Ehli, Erik A ^c   Davies, Gareth E ^c   Scheet, Paul A ^d   Xiao, Xiangjun ^e   Hudziak, James J ^f   Hottenga, Jouke Jan ^a   Neale, Ben M ^g,h   Boomsma, Dorret I ^a,b  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Avera Institute for Human Genetics   (United States)

^d UNIVERSITY OF TEXAS   (United States)

^e DARTMOUTH MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

ADHD; attention problems; dimensional models; genetics; polygenic scores

Indexed keywords

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; ATTENTION DISTURBANCE; ATTENTION PROBLEMS SCALE SCORE; CHILD; CONTROLLED STUDY; GENETIC ASSOCIATION; HUMAN; HYPERACTIVITY; INATTENTION; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); MOTHER; PHENOTYPE; POLYGENIC RISK SCORE; PREDICTIVE VALUE; PRESCHOOL CHILD; SCHOOL CHILD; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; TEACHER;

EID: 84907538769     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1016/j.jaac.2014.06.014     Document Type: Article

References (46)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 5 ed. 2013 American Psychiatric Publishing Arlington, VA
2. G. Polanczyk, M.S. de Lima, B.L. Horta, J. Biederman, and L.A. Rohde The worldwide prevalence of ADHD: a systematic review and metaregression analysis Am J Psychiatry 164 2007 942 948
3. World Health Organisation ICD-10 Classifications of Mental and Behavioural Disorder: Clinical Descriptions and Diagnostic Guidelines 1992 World Health Organisation Geneva
4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, text rev ed. Washington, DC;2000.
5. J.J. Hudziak, T.M. Achenbach, R.R. Althoff, and D.S. Pine A dimensional approach to developmental psychopathology Int J Methods Psychiatr Res 16 Suppl 1 2007 S16 S23
6. G.H. Lubke, J.J. Hudziak, E.M. Derks, T.C. van Bijsterveldt, and D.I. Boomsma Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum J Am Acad Child Adolesc Psychiatry 48 2009 1085 1093
7. A. Pickles, and A. Angold Natural categories or fundamental dimensions: on carving nature at the joints and the rearticulation of psychopathology Dev Psychopathol 15 2003 529 551
8. E.M. Derks, J.J. Hudziak, C.E. Beijsterveldt, C.V. Dolan, and D.I. Boomsma Genetic analyses of maternal and teacher ratings on attention problems in 7-year-old Dutch twins Behav Genet 36 2006 833 844
9. J. Kuntsi, F. Rijsdijk, A. Ronald, P. Asherson, and R. Plomin Genetic influences on the stability of attention-deficit/hyperactivity disorder symptoms from early to middle childhood Biol Psychiatry 57 2005 647 654
10. M.J. Rietveld, J.J. Hudziak, M. Bartels, C.E. van Beijsterveldt, and D.I. Boomsma Heritability of attention problems in children: longitudinal results from a study of twins, age 3 to 12 J Child Psychol Psychiatry 45 2004 577 588
11. K.-J. Kan, C.V. Dolan, and M.G. Nivard Genetic and environmental stability in attention problems across the lifespan: evidence from the Netherlands Twin Register J Am Acad Child Adolesc Psychiatry 52 2013 12 25
12. H. Larsson, H. Anckarsater, M. Rastam, Z. Chang, and P. Lichtenstein Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs J Child Psychol Psychiatry 53 2012 73 80
13. L.J. Eaves, J.L. Silberg, and J.M. Meyer Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development J Child Psychol Psychiatry 38 1997 965 980
14. H. Gjone, J. Stevenson, and J.M. Sundet Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample J Am Acad Child Adolesc Psychiatry 35 1996 588 596
15. J.J. Hudziak, L.P. Rudiger, M.C. Neale, A.C. Heath, and R.D. Todd A twin study of inattentive, aggressive, and anxious/depressed behaviors J Am Acad Child Adolesc Psychiatry 39 2000 469 476
16. M.J. Rietveld, J.J. Hudziak, M. Bartels, C.E. van Beijsterveldt, and D.I. Boomsma Heritability of attention problems in children: I. Cross-sectional results from a study of twins, age 3-12 years Am J Med Genet B Neuropsychiatr Genet 117B 2003 102 113
17. D.K. Sherman, M.K. McGue, and W.G. Iacono Twin concordance for attention deficit hyperactivity disorder: a comparison of teachers' and mothers' reports Am J Psychiatry 154 1997 532 535
18. B.M. Neale, S.E. Medland, and S. Ripke Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder J Am Acad Child Adolesc Psychiatry 49 2010 884 897
19. Cross-Disorder Group of the Psychiatric Genomics Consortium S.H. Lee, and S. Ripke Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs Nat Genet 45 2013 984 994
20. S.M. Purcell, N.R. Wray, and J.L. Stone Common polygenic variation contributes to risk of schizophrenia and bipolar disorder Nature 460 2009 748 752
21. N.R. Wray, J. Yang, B.J. Hayes, A.L. Price, M.E. Goddard, and P.M. Visscher Pitfalls of predicting complex traits from SNPs Nat Rev Genet 14 2013 507 515
22. M.L. Hamshere, K. Langley, and J. Martin High loading of polygenic risk for ADHD in children with comorbid aggression Am J Psychiatry 170 2013 909 916
23. E.M. Derks, J.A. Vorstman, S. Ripke, R.S. Kahn, and R.A. Ophoff Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis PLoS One 7 2012 e37852
24. A. Demirkan, B.W. Penninx, and K. Hek Genetic risk profiles for depression and anxiety in adult and elderly cohorts Mol Psychiatry 16 2011 773 783
25. C.E. van Beijsterveldt, M. Groen-Blokhuis, and J.J. Hottenga The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children Twin Res Hum Genet 16 2013 252 267
26. G. Willemsen, J.M. Vink, and A. Abdellaoui The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection Twin Res Hum Genet 16 2013 271 281
27. T.M. Achenbach, and L.A. Rescorla Manual for the ASEBA Preschool forms and Profiles 2000 University of Vermont, Research Center for Children, Youth, and Families Burlington, VT
28. T.M. Achenbach, and L.A. Rescorla Manual for the ASEBA School-Age Forms and Profiles 2001 University of Vermont, Research Center for Children, Youth, and Families Burlington, VT
29. A. Abdellaoui, J.J. Hottenga, and P. de Knijff Population structure, migration, and diversifying selection in the Netherlands Eur J Hum Genet 21 2013 1277 1285
30. E.L. Lehmann Nonparametrics: Statistical Methods Based on Ranks 1975 Holden-Day San Francisco
31. T.W. Frazier, E.A. Youngstrom, and R.I. Naugle The latent structure of attention-deficit/hyperactivity disorder in a clinic-referred sample Neuropsychology 21 2007 45 64
32. J.J. Hudziak, A.C. Heath, and P.F. Madden Latent class and factor analysis of DSM-IV ADHD: a twin study of female adolescents J Am Acad Child Adolesc Psychiatry 37 1998 848 857
33. G.H. Lubke, B. Muthen, and I.K. Moilanen Subtypes versus severity differences in attention-deficit/hyperactivity disorder in the Northern Finnish Birth Cohort J Am Acad Child Adolesc Psychiatry 46 2007 1584 1593
34. R.J. Neuman, R.D. Todd, and A.C. Heath Evaluation of ADHD typology in three contrasting samples: a latent class approach J Am Acad Child Adolesc Psychiatry 38 1999 25 33
35. R.D. Todd, E.R. Rasmussen, and R.J. Neuman Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins Am J Psychiatry 158 2001 1891 1898
36. B.N. Cuthbert, and T.R. Insel Toward the future of psychiatric diagnosis: the seven pillars of RDoC BMC Med 11 2013 126
37. D. Rettew Child Temperament: New Thinking about the Boundary between Traits and Illness 2013 W.W. Norton and Company New York
38. E.L. de Zeeuw, C.E. van Beijsterveldt, and T.J. Glasner Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children Am J Med Genet B Neuropsychiatr Genet 165 2014 510 520
39. D.F. Levinson, J. Shi, and K. Wang Genome-wide association study of multiplex schizophrenia pedigrees Am J Psychiatry 169 2012 963 973
40. R. Anney, L. Klei, and D. Pinto Individual common variants exert weak effects on the risk for autism spectrum disorderspi Hum Mol Genet 21 2012 4781 4792
41. P.M. Visscher, J. Yang, and M.E. Goddard A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al Twin Res Hum Genet 13 2010 517 524
42. S.H. Lee, and N.R. Wray Novel genetic analysis for case-control genome-wide association studies: quantification of power and genomic prediction accuracy PLoS One 8 2013 e71494
43. J. Yang, N.R. Wray, and P.M. Visscher Comparing apples and oranges: equating the power of case-control and quantitative trait association studies Genet Epidemiol 34 2010 254 257
44. R. Plomin, C.M. Haworth, and O.S. Davis Common disorders are quantitative traits Nat Rev Genet 10 2009 872 878
45. A. Thapar, R. Harrington, K. Ross, and P. McGuffin Does the definition of ADHD affect heritability? J Am Acad Child Adolesc Psychiatry 39 2000 1528 1536
46. th ed) 2008 Wiley-Blackwell Hoboken, NJ