Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line

Biochemical and Biophysical Research Communications

Volumn 452, Issue 3, 2014, Pages 315-321

  Ogura, Naoki ^a   Watashi, Koichi ^b   Noguchi, Toru ^a   Wakita, Takaji ^b  

^a JAPAN TOBACCO INC   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Antiviral; cccDNA; HBV

Indexed keywords

ANTIVIRUS AGENT; CCC 0975; CHEMICAL COMPOUND; EMTRICITABINE; ENTECAVIR; HEPATITIS B(E) ANTIGEN; LEFLUNOMIDE; METACYCLINE; MYCOPHENOLIC ACID; NELARABINE; OXYTETRACYCLINE; PITAVASTATIN; PROGESTERONE; TELBIVUDINE; TENOFOVIR; TETRACYCLINE; UNCLASSIFIED DRUG; ZALCITABINE; CIRCULAR DNA; MOLECULAR LIBRARY; PROTEIN SYNTHESIS INHIBITOR; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; COMPARATIVE STUDY; COVALENT BOND; DNA REPLICATION; DNA STRUCTURE; DNA SYNTHESIS; DRUG SCREENING; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; KINETICS; NORTHERN BLOTTING; NUCLEIC ACID ANALYSIS; PRODUCTIVITY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SOUTHERN BLOTTING; VIRUS EXPRESSION; VIRUS INDUCTION; VIRUS PARTICLE; VIRUS REPLICATION; BIOSYNTHESIS; DRUG EFFECTS; FOUNDER EFFECT; GENE EXPRESSION; GENETICS; HIGH THROUGHPUT SCREENING; LIVER CELL; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; TRANSFORMED CELL LINE; VIROLOGY;

ANTIVIRAL AGENTS; CELL LINE, TRANSFORMED; DNA, CIRCULAR; DNA, VIRAL; FOUNDER EFFECT; GENE EXPRESSION; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PROTEIN SYNTHESIS INHIBITORS; SMALL MOLECULE LIBRARIES; TETRACYCLINE; VIRUS REPLICATION;

EID: 84907537597     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.08.029     Document Type: Article

References (39)

1. P. Ocama, C.K. Opio, and W.M. Lee Hepatitis B virus infection: current status Am. J. Med. 118 2005 1413.e15-1413.e22
2. J.J. Ott, G.A. Stevens, J. Groeger, and S.T. Wiersma Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity Vaccine 30 12 2012 2212 2219
3. T.M. Block, H. Guo, and J.T. Guo Molecular virology of hepatitis B virus for clinicians Clin. Liver Dis. 11 4 2007 685 706 vii
4. T.J. Liang Hepatitis B: the virus and disease Hepatology 49 2009 S13 S21
5. B.J. McMahon Epidemiology and natural history of hepatitis B Semin. Liver Dis. 25 Suppl. 1 2005 3 8
6. D. Ganem, and H.E. Varmus The molecular biology of the hepatitis B viruses Annu. Rev. Biochem. 56 1987 651 693
7. M. Nassal Hepatitis B viruses: reverse transcription a different way Virus Res. 134 1-2 2008 235 249
8. C. Seeger, and W.S. Mason Hepatitis B virus biology Microbiol. Mol. Biol. Rev. 64 1 2000 51 68
9. G. Moraleda, J. Saputelli, C.E. Aldrich, D. Averett, L. Condreay, and W.S. Mason Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus J. Virol. 71 12 1997 9392 9399
10. J. Summers, P.M. Smith, and A.L. Horwich Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification J. Virol. 64 6 1990 2819 2824
11. J.S. Tuttleman, C. Pourcel, and J. Summers Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells Cell 47 3 1986 451 460
12. T.T. Wu, L. Coates, C.E. Aldrich, J. Summers, and W.S. Mason In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplified by an intracellular pathway Virology 175 1 1990 255 261
13. Y.Y. Zhang, B.H. Zhang, D. Theele, S. Litwin, E. Toll, and J. Summers Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver Proc. Natl. Acad. Sci. U.S.A. 100 21 2003 12372 12377
14. H. Guo, D. Jiang, T. Zhou, A. Cuconati, T.M. Block, and J.T. Guo Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation J. Virol. 81 22 2007 12472 12484
15. Y. Zhu, T. Yamamoto, J. Cullen, J. Saputelli, C.E. Aldrich, D.S. Miller, S. Litwin, P.A. Furman, A.R. Jilbert, and W.S. Mason Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis J. Virol. 75 1 2001 311 322
16. F. Zoulim New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA J. Hepatol. 42 3 2005 302 308
17. P.P. Scaglioni, M. Melegari, and J.R. Wands Posttranscriptional regulation of hepatitis B virus replication by the precore protein J. Virol. 71 1 1997 345 353
18. S.K. Ladner, M.J. Otto, C.S. Barker, K. Zaifert, G.H. Wang, J.T. Guo, C. Seeger, and R.W. King Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication Antimicrob. Agents Chemother. 41 8 1997 1715 1720
19. J. Wang, A.S. Lee, and J.H. Ou Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment J. Virol. 65 9 1991 5080 5083
20. T. Zhou, H. Guo, J.T. Guo, A. Cuconati, A. Mehta, and T.M. Block Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays Antiviral Res. 72 2 2006 116 124
21. M.A. Sells, A.Z. Zelent, M. Shvartsman, and G. Acs Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions J. Virol. 62 8 1988 2836 2844
22. J.T. Guo, M. Pryce, X. Wang, M.I. Barrasa, J. Hu, and C. Seeger Conditional replication of duck hepatitis B virus in hepatoma cells J. Virol. 77 3 2003 1885 1893
23. H. Guo, W.S. Mason, C.E. Aldrich, J.R. Saputelli, D.S. Miller, A.R. Jilbert, and J.E. Newbold Identification and characterization of avihepadnaviruses isolated from exotic anseriformes maintained in captivity J. Virol. 79 5 2005 2729 2742
24. H. Guo, T. Zhou, D. Jiang, A. Cuconati, G.H. Xiao, T.M. Block, and J.T. Guo Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway J. Virol. 81 18 2007 10072 10080
25. D. Cai, H. Nie, R. Yan, J.T. Guo, T.M. Block, and H. Guo A Southern blot assay for detection of hepatitis B virus covalently closed circular DNA from cell cultures Methods Mol. Biol. 1030 2013 151 161
26. H. Guo, C.E. Aldrich, J. Saputelli, C. Xu, and W.S. Mason The insertion domain of the duck hepatitis B virus core protein plays a role in nucleocapsid assembly Virology 353 2006 443 450
27. H. Guo, R. Mao, T.M. Block, and J.T. Guo Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses J. Virol. 84 1 2010 387 396
28. B. Hirt Selective extraction of polyoma DNA from infected mouse cell cultures J. Mol. Biol. 26 2 1967 365 369
29. R.J. Lenhoff, and J. Summers Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus J. Virol. 68 7 1994 4565 4571
30. K. Watashi, G. Liang, M. Iwamoto, H. Marusawa, N. Uchida, T. Daito, K. Kitamura, M. Muramatsu, H. Ohashi, T. Kiyohara, R. Suzuki, J. Li, S. Tong, Y. Tanaka, K. Murata, H. Aizaki, and T. Wakita Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID) J. Biol. Chem. 288 44 2013 31715 31727
31. K. Watashi, A. Sluder, T. Daito, S. Matsunaga, A. Ryo, S. Nagamori, M. Iwamoto, S. Nakajima, S. Tsukuda, K. Borroto-Esoda, M. Sugiyama, Y. Tanaka, Y. Kanai, H. Kusuhara, M. Mizokami, and T. Wakita Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter NTCP Hepatology 59 5 2014 1726 1737
32. A. Laras, J. Koskinas, E. Dimou, A. Kostamena, and S.J. Hadziyannis Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients Hepatology 44 3 2006 694 702
33. M. Maynard, P. Parvaz, S. Durantel, M. Chevallier, P. Chevallier, M. Lot, C. Trepo, and F. Zoulim Sustained HBs seroconversion during lamivudine and adefovir dipivoxil combination therapy for lamivudine failure J. Hepatol. 42 2 2005 279 281
34. B. Werle-Lapostolle, S. Bowden, S. Locarnini, K. Wursthorn, J. Petersen, G. Lau, C. Trepo, P. Marcellin, Z. Goodman, W.E.T. Delaney, S. Xiong, C.L. Brosgart, S.S. Chen, C.S. Gibbs, and F. Zoulim Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy Gastroenterology 126 7 2004 1750 1758
35. D.K. Wong, M.F. Yuen, H. Yuan, S.S. Sum, C.K. Hui, J. Hall, and C.L. Lai Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients Hepatology 40 3 2004 727 737
36. C. Niu, H. Bao, T. Tolstykh, H.M. Micolochick Steuer, E. Murakami, B. Korba, and P.A. Furman Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors Antivir. Ther. 15 3 2010 401 412
37. D. Cai, C. Mills, W. Yu, R. Yan, C.E. Aldrich, J.R. Saputelli, W.S. Mason, X. Xu, J.T. Guo, T.M. Block, A. Cuconati, and H. Guo Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation Antimicrob. Agents Chemother. 56 8 2012 4277 4288
38. J. Price An update on hepatitis B, d, and e viruses Top. Antivir. Med. 21 5 2013 157 163
39. Z.J. Gong, S. De Meyer, C. Clarysse, C. Verslype, J. Neyts, E. De Clercq, and S.H. Yap Mycophenolic acid, an immunosuppressive agent, inhibits HBV replication in vitro J. Viral Hepat. 6 3 1999 229 236